CRCGN016_MCF10A.TP53.M_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlormadinone acetate 99.12 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
S100A4 S100 calcium binding protein A4 3.86805
PDLIM1 PDZ and LIM domain 1 3.57616
UGDH UDP-glucose 6-dehydrogenase 3.48634
GLRX glutaredoxin (thioltransferase) 3.45271
NUCB2 nucleobindin 2 3.32027
FHL2 four and a half LIM domains 2 3.15772
FKBP14 FK506 binding protein 14, 22 kDa 3.1208
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.04136
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.93169
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.85822
IER3 immediate early response 3 2.84566
DUSP4 dual specificity phosphatase 4 2.83416
C2CD2 C2 calcium-dependent domain containing 2 2.83079
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.76333
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.58491
ALDOC aldolase C, fructose-bisphosphate 2.38891
HSPA1A heat shock 70kDa protein 1A 2.36418
PRR7 proline rich 7 (synaptic) 2.3564
IL1B interleukin 1, beta 2.29083
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.28982
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.25229
GALE UDP-galactose-4-epimerase 2.24162
ADAM9 ADAM metallopeptidase domain 9 2.2101
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.19708
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.19251
INSIG1 insulin induced gene 1 2.18962
TGFBI transforming growth factor, beta-induced, 68kDa 2.16289
LGMN legumain 2.15482
B3GAT3 beta-1,3-glucuronyltransferase 3 2.14299
CHD1 chromodomain helicase DNA binding protein 1 2.10054
LONP2 lon peptidase 2, peroxisomal 2.07566
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.06205
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.0589
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.05149
ARHGAP22 Rho GTPase activating protein 22 2.0349
CNPY3 canopy FGF signaling regulator 3 2.02609
ZC3H12A zinc finger CCCH-type containing 12A 2.00495

decreased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface -4.83866
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.16907
OXCT1 3-oxoacid CoA transferase 1 -4.08607
TSC22D3 TSC22 domain family, member 3 -4.02289
TSPAN4 tetraspanin 4 -3.97028
NFIL3 nuclear factor, interleukin 3 regulated -3.77912
PRR15L proline rich 15-like -3.33569
PMM2 phosphomannomutase 2 -3.23613
CD58 CD58 molecule -3.22912
CDK4 cyclin-dependent kinase 4 -3.19004
GPR171 G protein-coupled receptor 171 -3.11583
CD320 CD320 molecule -3.10262
XPO7 exportin 7 -3.10104
OXA1L oxidase (cytochrome c) assembly 1-like -3.09608
COG2 component of oligomeric golgi complex 2 -3.04765
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -3.02797
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.9076
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.88777
PCCB propionyl CoA carboxylase, beta polypeptide -2.86751
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.82713
MCM3 minichromosome maintenance complex component 3 -2.70315
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.64323
PLA2G2D phospholipase A2, group IID -2.56145
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.55683
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.53301
COQ6 coenzyme Q6 monooxygenase -2.49796
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.49435
THRAP3 thyroid hormone receptor associated protein 3 -2.46976
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.40061
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.39942
PGAM4 phosphoglycerate mutase family member 4 -2.3922
NAP1L4 nucleosome assembly protein 1-like 4 -2.38403
INTS3 integrator complex subunit 3 -2.35698
LDHD lactate dehydrogenase D -2.33044
CIRBP cold inducible RNA binding protein -2.29914
STMN1 stathmin 1 -2.29402
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.29338
COQ9 coenzyme Q9 -2.29243
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.27502
RPA3 replication protein A3, 14kDa -2.26453
CDK1 cyclin-dependent kinase 1 -2.26328
WDR73 WD repeat domain 73 -2.22737
GNAS GNAS complex locus -2.21829
EAPP E2F-associated phosphoprotein -2.21769
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.21764
CD2 CD2 molecule -2.18636
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.17586
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.16331
ZNF16 zinc finger protein 16 -2.1416
TP53 tumor protein p53 -2.12545
HADH hydroxyacyl-CoA dehydrogenase -2.12383
NUBP2 nucleotide binding protein 2 -2.10864
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.09924
UTRN utrophin -2.09777
IVL involucrin -2.07599
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.06299
NELFCD negative elongation factor complex member C/D -2.0533
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.05228
RGS2 regulator of G-protein signaling 2 -2.04214
ERH enhancer of rudimentary homolog (Drosophila) -2.04012
PEX11B peroxisomal biogenesis factor 11 beta -2.02498
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.0224
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -2.0178