CRCGN016_MCF10A.TP53.M_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlormadinone acetate 33.04 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

159 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
USP6NL USP6 N-terminal like 5.50355
MAMLD1 mastermind-like domain containing 1 5.32285
STXBP1 syntaxin binding protein 1 5.32265
FHL2 four and a half LIM domains 2 3.907
TSPAN6 tetraspanin 6 3.51765
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.44615
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 3.278
ACBD3 acyl-CoA binding domain containing 3 3.0766
FKBP14 FK506 binding protein 14, 22 kDa 2.97495
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.97225
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.86045
IER3 immediate early response 3 2.75295
PAQR4 progestin and adipoQ receptor family member IV 2.71435
TMEM41B transmembrane protein 41B 2.69865
MELK maternal embryonic leucine zipper kinase 2.6577
DUSP4 dual specificity phosphatase 4 2.6564
ALDOC aldolase C, fructose-bisphosphate 2.5648
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.5414
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.50943
GSTZ1 glutathione S-transferase zeta 1 2.4522
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 2.43125
IL1B interleukin 1, beta 2.42023
NCK2 NCK adaptor protein 2 2.4113
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.3999
SATB1 SATB homeobox 1 2.3771
C1QL1 complement component 1, q subcomponent-like 1 2.3687
MCUR1 mitochondrial calcium uniporter regulator 1 2.3265
NECTIN2 nectin cell adhesion molecule 2 2.29985
EPN2 epsin 2 2.29568
DGKD diacylglycerol kinase, delta 130kDa 2.26035
CYTH1 cytohesin 1 2.25275
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.2467
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.2436
UBAP1 ubiquitin associated protein 1 2.23605
MFSD6 major facilitator superfamily domain containing 6 2.21485
RHOBTB2 Rho-related BTB domain containing 2 2.21055
BST2 bone marrow stromal cell antigen 2 2.2024
LRP10 low density lipoprotein receptor-related protein 10 2.1973
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.19505
C2CD2 C2 calcium-dependent domain containing 2 2.1926
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.16415
H1-0 H1.0 linker histone 2.15505
CLCC1 chloride channel CLIC-like 1 2.1458
PIBF1 progesterone immunomodulatory binding factor 1 2.1292
PYGL phosphorylase, glycogen, liver 2.12065
INSIG1 insulin induced gene 1 2.10163
G0S2 G0/G1 switch 2 2.10045
CD70 CD70 molecule 2.0998
MYDGF myeloid-derived growth factor 2.0971
SLC35F2 solute carrier family 35, member F2 2.07515
GLRB glycine receptor, beta 2.074
ADIPOR2 adiponectin receptor 2 2.07025
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.047
SH3D19 SH3 domain containing 19 2.03568
WNT5A wingless-type MMTV integration site family, member 5A 2.03003
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.0254
GLRX glutaredoxin (thioltransferase) 2.02323
LIF leukemia inhibitory factor 2.0209
TLE3 transducin-like enhancer of split 3 2.01835
TASOR2 transcription activation suppressor family member 2 2.01065
WASF3 WAS protein family, member 3 2.01035
SMAD3 SMAD family member 3 2.00783

decreased expression

Symbol Name Standardized Value
GRWD1 glutamate-rich WD repeat containing 1 -5.7334
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -5.41525
SLC25A46 solute carrier family 25, member 46 -5.3008
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.24355
ADRB2 adrenoceptor beta 2, surface -5.18875
CCNB1 cyclin B1 -5.1604
DNM1L dynamin 1-like -4.9748
CDK4 cyclin-dependent kinase 4 -4.8908
NISCH nischarin -4.5311
NGRN neugrin, neurite outgrowth associated -4.05505
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.01493
GADD45B growth arrest and DNA-damage-inducible, beta -3.87997
KRT14 keratin 14, type I -3.7788
RGS2 regulator of G-protein signaling 2 -3.6043
PRR15L proline rich 15-like -3.5811
TSC22D3 TSC22 domain family, member 3 -3.3376
MRPS27 mitochondrial ribosomal protein S27 -3.30035
TCEAL4 transcription elongation factor A (SII)-like 4 -3.2856
TEX10 testis expressed 10 -3.1885
BID BH3 interacting domain death agonist -2.93515
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.87035
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.8337
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.78685
SETMAR SET domain and mariner transposase fusion gene -2.7718
CD2 CD2 molecule -2.72995
NFIL3 nuclear factor, interleukin 3 regulated -2.72865
REXO2 RNA exonuclease 2 -2.7146
EDN1 endothelin 1 -2.6527
RPA3 replication protein A3, 14kDa -2.5499
INTS13 integrator complex subunit 13 -2.456
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.42338
PLPP1 phospholipid phosphatase 1 -2.42088
SNX2 sorting nexin 2 -2.4079
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.4052
RIOK2 RIO kinase 2 -2.3775
GHR growth hormone receptor -2.3624
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.348
DCAF17 DDB1 and CUL4 associated factor 17 -2.33615
CCDC91 coiled-coil domain containing 91 -2.3361
UBA3 ubiquitin-like modifier activating enzyme 3 -2.32575
MED21 mediator complex subunit 21 -2.32113
CCL13 chemokine (C-C motif) ligand 13 -2.29855
CAPRIN2 caprin family member 2 -2.2926
EFNA3 ephrin-A3 -2.29085
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.28665
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.2814
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.27658
WASHC3 WASH complex subunit 3 -2.27585
GLUL glutamate-ammonia ligase -2.26918
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.26885
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.26585
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.25992
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.25555
CHMP4B charged multivesicular body protein 4B -2.23723
DCP2 decapping mRNA 2 -2.22995
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.2194
CCL23 chemokine (C-C motif) ligand 23 -2.21477
HSPB1 heat shock 27kDa protein 1 -2.19725
INTS15 integrator complex subunit 15 -2.19695
OXCT1 3-oxoacid CoA transferase 1 -2.18135
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.17985
RNFT1-DT RNFT1 divergent transcript -2.1612
ZSCAN5A zinc finger and SCAN domain containing 5A -2.15025
SLC61A1 solute carrier family 61 member 1 -2.12555
GOLGA8F golgin A8 family, member F -2.12185
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.11985
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.1164
ETNK1 ethanolamine kinase 1 -2.11573
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.11145
NUP107 nucleoporin 107kDa -2.10665
CNN1 calponin 1, basic, smooth muscle -2.10615
ANXA4 annexin A4 -2.09583
HARS1 histidyl-tRNA synthetase 1 -2.0958
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.0875
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.08325
CAPN1 calpain 1, (mu/I) large subunit -2.08285
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.08225
ZNF33B zinc finger protein 33B -2.07695
MRPL11 mitochondrial ribosomal protein L11 -2.0729
F5 coagulation factor V (proaccelerin, labile factor) -2.07238
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.0628
ZNF669 zinc finger protein 669 -2.05975
MFAP5 microfibrillar associated protein 5 -2.05812
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 -2.05447
ECSIT ECSIT signalling integrator -2.05315
AHCY adenosylhomocysteinase -2.0446
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -2.0336
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.03175
ESD esterase D -2.02715
NSUN5 NOP2/Sun domain family, member 5 -2.02128
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.02075
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.0178
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.017
RBM42 RNA binding motif protein 42 -2.01515
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -2.0059
HOXB3 homeobox B3 -2.0055
ZNF165 zinc finger protein 165 -2.00255