CRCGN016_MCF10A.TP53.M_24H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlormadinone acetate 11.01 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.75493
CADM1 cell adhesion molecule 1 3.71798
BTK Bruton agammaglobulinemia tyrosine kinase 3.64811
ALDOC aldolase C, fructose-bisphosphate 3.43775
FHL2 four and a half LIM domains 2 3.20986
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.86161
LSP1 lymphocyte-specific protein 1 2.77077
LOC122526780 uncharacterized LOC122526780 2.73861
LYN LYN proto-oncogene, Src family tyrosine kinase 2.6978
LGMN legumain 2.54163
SYNGAP1 synaptic Ras GTPase activating protein 1 2.54009
CNPY3 canopy FGF signaling regulator 3 2.53312
IL1B interleukin 1, beta 2.52819
CHEK1 checkpoint kinase 1 2.52694
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.42225
COPS7A COP9 signalosome subunit 7A 2.33029
STK10 serine/threonine kinase 10 2.29599
COL15A1 collagen, type XV, alpha 1 2.29123
INSIG1 insulin induced gene 1 2.27347
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.23312
GATA2 GATA binding protein 2 2.15327
NALF1 NALCN channel auxiliary factor 1 2.09226
DNM3 dynamin 3 2.08644
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.04078
FAT1 FAT atypical cadherin 1 2.03001
TBCCD1 TBCC domain containing 1 2.02275
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 2.00976

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -7.04993
MRPS16 mitochondrial ribosomal protein S16 -4.86494
ACOT9 acyl-CoA thioesterase 9 -4.78123
KRT14 keratin 14, type I -4.69204
TXNDC9 thioredoxin domain containing 9 -4.28232
NGRN neugrin, neurite outgrowth associated -3.81095
TUBB6 tubulin, beta 6 class V -3.47381
BASP1 brain abundant, membrane attached signal protein 1 -3.3638
ADRB2 adrenoceptor beta 2, surface -3.0972
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.0648
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.98889
MRPS2 mitochondrial ribosomal protein S2 -2.9543
COX5B cytochrome c oxidase subunit Vb -2.95269
MT1X metallothionein 1X -2.95007
TEX10 testis expressed 10 -2.84429
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.84354
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.81652
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.66729
TSC22D3 TSC22 domain family, member 3 -2.65177
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.61903
HSPB1 heat shock 27kDa protein 1 -2.581
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.57287
LMAN2L lectin, mannose-binding 2-like -2.51502
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.4903
INTS3 integrator complex subunit 3 -2.4546
DCK deoxycytidine kinase -2.44619
LAMP3 lysosomal-associated membrane protein 3 -2.42851
MTCH2 mitochondrial carrier 2 -2.40278
RGS2 regulator of G-protein signaling 2 -2.39789
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.29019
NFE2L1 nuclear factor, erythroid 2-like 1 -2.24345
CCL13 chemokine (C-C motif) ligand 13 -2.24121
HPS6 Hermansky-Pudlak syndrome 6 -2.23537
PRR15L proline rich 15-like -2.22864
OXA1L oxidase (cytochrome c) assembly 1-like -2.18711
UBL5 ubiquitin-like 5 -2.18056
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.17424
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -2.16616
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.15848
MT2A metallothionein 2A -2.15519
CXCL13 chemokine (C-X-C motif) ligand 13 -2.15364
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.14433
NFIL3 nuclear factor, interleukin 3 regulated -2.13463
KIF22 kinesin family member 22 -2.13242
AHCY adenosylhomocysteinase -2.12353
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.1134
TP53I3 tumor protein p53 inducible protein 3 -2.09762
CDT1 chromatin licensing and DNA replication factor 1 -2.09159
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.08983
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.06736
DDTL D-dopachrome tautomerase-like -2.06586
TCTA T-cell leukemia translocation altered -2.05833
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.03564
ZBTB16 zinc finger and BTB domain containing 16 -2.03384
PRDX4 peroxiredoxin 4 -2.0236
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.02204
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.02167
PROCR protein C receptor, endothelial -2.0147
TMEM265 transmembrane protein 265 -2.01446
ADGRE5 adhesion G protein-coupled receptor E5 -2.01093
TMEM127 transmembrane protein 127 -2.0012