CRCGN016_MCF10A.TP53.M_24H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-toluidine.hcl 99.26 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 5.85757
GADD45A growth arrest and DNA-damage-inducible, alpha 5.65985
ABHD4 abhydrolase domain containing 4 4.96135
CLNS1A chloride channel, nucleotide-sensitive, 1A 4.82185
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 4.26762
MICALL1 MICAL-like 1 3.67933
TMEM50A transmembrane protein 50A 3.11185
GAB2 GRB2-associated binding protein 2 3.09885
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.91045
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.89045
LGALS14 lectin, galactoside-binding, soluble, 14 2.86395
AAMDC adipogenesis associated, Mth938 domain containing 2.77325
RSF1 remodeling and spacing factor 1 2.7668
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.72805
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.7174
UVRAG UV radiation resistance associated 2.6679
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.658
CAPN5 calpain 5 2.58935
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.55555
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.5203
TPD52L2 tumor protein D52-like 2 2.51035
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.5063
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 2.46287
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.427
HOXB9 homeobox B9 2.41745
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.389
NFE2 nuclear factor, erythroid 2 2.3609
TF transferrin 2.33111
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.30905
THAP12 THAP domain containing 12 2.28605
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.26203
OCLN occludin 2.2618
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.25015
MRPS18C mitochondrial ribosomal protein S18C 2.2486
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.24795
PKN1 protein kinase N1 2.24553
FIP1L1 factor interacting with PAPOLA and CPSF1 2.22775
CTSE cathepsin E 2.22665
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.2184
VDAC3 voltage-dependent anion channel 3 2.2075
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.2028
GOLGA7 golgin A7 2.20105
FNTA farnesyltransferase, CAAX box, alpha 2.19765
ADIPOR2 adiponectin receptor 2 2.16375
IL18R1 interleukin 18 receptor 1 2.14375
TOR1A torsin family 1, member A (torsin A) 2.13643
HYOU1 hypoxia up-regulated 1 2.1208
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.10765
KLF3 Kruppel-like factor 3 (basic) 2.1055
C4BPB complement component 4 binding protein, beta 2.09615
APOA2 apolipoprotein A-II 2.09105
THEMIS2 thymocyte selection associated family member 2 2.09072
IMPACT impact RWD domain protein 2.07835
ITGB7 integrin, beta 7 2.078
HBZ hemoglobin, zeta 2.07715
HLA-DMA major histocompatibility complex, class II, DM alpha 2.07475
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.07406
ZNF280D zinc finger protein 280D 2.07055
LCOR ligand dependent nuclear receptor corepressor 2.0665
TBC1D22B TBC1 domain family, member 22B 2.05715
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.05475
ADA adenosine deaminase 2.0531
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.04935
APOA1 apolipoprotein A-I 2.04685
ZMYM6 zinc finger, MYM-type 6 2.0468
TTC27 tetratricopeptide repeat domain 27 2.0391
TEF thyrotrophic embryonic factor 2.0323
PKD2L2 polycystic kidney disease 2-like 2 2.0026

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -6.12905
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.7261
TSPAN4 tetraspanin 4 -5.52553
GRN granulin -5.46383
KIF14 kinesin family member 14 -5.35295
GOLT1B golgi transport 1B -5.09905
KIF20A kinesin family member 20A -4.91365
LYPLA1 lysophospholipase I -4.1565
IGFBP7 insulin-like growth factor binding protein 7 -4.14745
MT1X metallothionein 1X -3.65268
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.5449
KRT14 keratin 14, type I -3.3711
BASP1 brain abundant, membrane attached signal protein 1 -3.24215
HLA-G major histocompatibility complex, class I, G -2.47785
NT5DC2 5'-nucleotidase domain containing 2 -2.422
RECQL RecQ helicase-like -2.41489
SQSTM1 sequestosome 1 -2.3762
CRIP2 cysteine-rich protein 2 -2.31735
TAC4 tachykinin 4 (hemokinin) -2.2487
HLA-B major histocompatibility complex, class I, B -2.23328
HLA-E major histocompatibility complex, class I, E -2.23005
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.2175
IST1 increased sodium tolerance 1 homolog (yeast) -2.20275
IGFBP4 insulin-like growth factor binding protein 4 -2.17785
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.1297
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.10925
TMEM208 transmembrane protein 208 -2.0561
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.0426
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.03325
TSPO translocator protein (18kDa) -2.00485