CRCGN016_MCF10A.TP53.M_24H:P08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-toluidine.hcl 33.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 6.07037
PEX11A peroxisomal biogenesis factor 11 alpha 5.88055
RAB21 RAB21, member RAS oncogene family 5.24605
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 4.7358
SPAG4 sperm associated antigen 4 4.70425
CCNA1 cyclin A1 3.8088
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.32235
TOMM34 translocase of outer mitochondrial membrane 34 3.00855
PDLIM1 PDZ and LIM domain 1 2.78995
RPH3A rabphilin 3A 2.72155
MCUR1 mitochondrial calcium uniporter regulator 1 2.64495
AGR2 anterior gradient 2 2.5874
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.5276
STMN2 stathmin 2 2.51195
ZFC3H1 zinc finger, C3H1-type containing 2.46625
ELOVL2 ELOVL fatty acid elongase 2 2.3967
TBC1D15 TBC1 domain family, member 15 2.243
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.2418
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.1657
STK10 serine/threonine kinase 10 2.13687
HYOU1 hypoxia up-regulated 1 2.0617
CAND1 cullin-associated and neddylation-dissociated 1 2.05688
LAMP5 lysosomal-associated membrane protein family, member 5 2.00265

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -5.09475
NPDC1 neural proliferation, differentiation and control, 1 -4.67135
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.88845
ZMYM2 zinc finger, MYM-type 2 -3.13898
PDE9A phosphodiesterase 9A -2.4496
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.4258
CBR3 carbonyl reductase 3 -2.3974
IL4R interleukin 4 receptor -2.3496
NELFA negative elongation factor complex member A -2.1017
MRPL57 mitochondrial ribosomal protein L57 -2.1015
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.0292