CRCGN016_MCF10A.TP53.M_24H:P09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-toluidine.hcl 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.06217
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.9067
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 4.5346
PDLIM1 PDZ and LIM domain 1 4.4967
FGFR4 fibroblast growth factor receptor 4 4.36652
PRR7 proline rich 7 (synaptic) 2.8762
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.8358
RAB21 RAB21, member RAS oncogene family 2.81265
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.55125
SCGN secretagogin, EF-hand calcium binding protein 2.2558
NSG2 neuronal vesicle trafficking associated 2 2.24
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.1742
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.14505
RSRC1 arginine/serine-rich coiled-coil 1 2.1191
SNCB synuclein, beta 2.11575
EXD3 exonuclease 3'-5' domain containing 3 2.036
DOK4 docking protein 4 2.02188
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.0201

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.11055
KRT14 keratin 14, type I -5.0
CDC45 cell division cycle 45 -4.5229
TRAPPC3 trafficking protein particle complex 3 -4.35938
NRIP1 nuclear receptor interacting protein 1 -4.23057
CAPN2 calpain 2, (m/II) large subunit -3.42252
TLK2 tousled-like kinase 2 -3.31582
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.2444
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.14538
REXO2 RNA exonuclease 2 -3.01089
RPS5 ribosomal protein S5 -2.9183
MRPS15 mitochondrial ribosomal protein S15 -2.7756
SKAP1 src kinase associated phosphoprotein 1 -2.49755
CERS2 ceramide synthase 2 -2.393
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.2805
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.1655
MED13 mediator complex subunit 13 -2.0699
RPLP2 ribosomal protein, large, P2 -2.05325
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.04485
MEAF6 MYST/Esa1-associated factor 6 -2.04345
RGN regucalcin -2.04075
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.02835