| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | leucomalachite green 32.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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248 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 9.27189 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 7.65692 |
| XPOT | exportin, tRNA | 5.03518 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 4.87641 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 4.8624 |
| SSBP2 | single-stranded DNA binding protein 2 | 4.83159 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 4.76622 |
| AARS1 | alanyl-tRNA synthetase 1 | 4.62994 |
| PHGDH | phosphoglycerate dehydrogenase | 4.52901 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 4.48267 |
| GLRX | glutaredoxin (thioltransferase) | 4.36922 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.26472 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 4.25956 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.99258 |
| KDM5D | lysine (K)-specific demethylase 5D | 3.86123 |
| TXNRD1 | thioredoxin reductase 1 | 3.58479 |
| CETN3 | centrin, EF-hand protein, 3 | 3.50317 |
| GARS1 | glycyl-tRNA synthetase 1 | 3.44486 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 3.43908 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 3.42532 |
| CTSL | cathepsin L | 3.40654 |
| PSAT1 | phosphoserine aminotransferase 1 | 3.35619 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 3.29263 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 3.24015 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 3.2285 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 3.08932 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.9768 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | 2.95677 |
| MARS1 | methionyl-tRNA synthetase 1 | 2.90208 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 2.88753 |
| ODR4 | odr-4 GPCR localization factor homolog | 2.84699 |
| LMO4 | LIM domain only 4 | 2.82297 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 2.80581 |
| UFM1 | ubiquitin-fold modifier 1 | 2.78663 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 2.76614 |
| TRIB3 | tribbles pseudokinase 3 | 2.75944 |
| HMOX1 | heme oxygenase 1 | 2.73429 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 2.73214 |
| LOC128125814 | uncharacterized LOC128125814 | 2.72269 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 2.71846 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.68516 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 2.66455 |
| STK10 | serine/threonine kinase 10 | 2.66152 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 2.6568 |
| CAPRIN2 | caprin family member 2 | 2.61834 |
| HMGA2 | high mobility group AT-hook 2 | 2.5834 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.55598 |
| ACTR6 | ARP6 actin-related protein 6 homolog (yeast) | 2.48483 |
| ATP11B | ATPase, class VI, type 11B | 2.48285 |
| SQSTM1 | sequestosome 1 | 2.46843 |
| IL24 | interleukin 24 | 2.43063 |
| GOLGA3 | golgin A3 | 2.42508 |
| CEP290 | centrosomal protein 290kDa | 2.41978 |
| IL1A | interleukin 1, alpha | 2.40932 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.40851 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 2.40828 |
| ATF4 | activating transcription factor 4 | 2.40618 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 2.40419 |
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | 2.38334 |
| SKIC3 | SKI3 subunit of superkiller complex | 2.38295 |
| TMEM50A | transmembrane protein 50A | 2.3718 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.36412 |
| PROS1 | protein S (alpha) | 2.35312 |
| IFRD1 | interferon-related developmental regulator 1 | 2.3459 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | 2.33885 |
| PRELID3B | PRELI domain containing 3B | 2.33737 |
| SQOR | sulfide quinone oxidoreductase | 2.33475 |
| EMC2 | ER membrane protein complex subunit 2 | 2.31807 |
| FAM169A | family with sequence similarity 169, member A | 2.31716 |
| LOC122526780 | uncharacterized LOC122526780 | 2.31533 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 2.31193 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 2.30864 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 2.28937 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.28869 |
| DENR | density-regulated protein | 2.27451 |
| SARS1 | seryl-tRNA synthetase 1 | 2.27217 |
| SECISBP2 | SECIS binding protein 2 | 2.27139 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.26779 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.24548 |
| FBLN2 | fibulin 2 | 2.24427 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 2.2408 |
| FHL2 | four and a half LIM domains 2 | 2.23771 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 2.23405 |
| TGIF1 | TGFB-induced factor homeobox 1 | 2.2298 |
| ECT2 | epithelial cell transforming 2 | 2.21201 |
| IL1B | interleukin 1, beta | 2.2083 |
| ZNF23 | zinc finger protein 23 | 2.20493 |
| LGMN | legumain | 2.18448 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.17976 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 2.17821 |
| TXLNA | taxilin alpha | 2.17277 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 2.17156 |
| DNAJB14 | DnaJ (Hsp40) homolog, subfamily B, member 14 | 2.17041 |
| TMEM267 | transmembrane protein 267 | 2.16446 |
| SLC13A3 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 | 2.14467 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 2.13857 |
| NT5M | 5',3'-nucleotidase, mitochondrial | 2.13167 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 2.11825 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) | 2.11433 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 2.11285 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.11258 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | 2.09897 |
| CCPG1 | cell cycle progression 1 | 2.09709 |
| NLGN4Y | neuroligin 4, Y-linked | 2.09176 |
| DNAJC24 | DnaJ (Hsp40) homolog, subfamily C, member 24 | 2.09 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 2.08798 |
| UFL1 | UFM1-specific ligase 1 | 2.08743 |
| FGF17 | fibroblast growth factor 17 | 2.08383 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.07468 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.07404 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 2.06286 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 2.05836 |
| COL16A1 | collagen, type XVI, alpha 1 | 2.05825 |
| PCDH9 | protocadherin 9 | 2.0538 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 2.0521 |
| LOC124900388 | uncharacterized LOC124900388 | 2.0484 |
| ATF3 | activating transcription factor 3 | 2.04569 |
| GPN3 | GPN-loop GTPase 3 | 2.03769 |
| TRIM5 | tripartite motif containing 5 | 2.03762 |
| LOC102724560 | cystathionine beta-synthase | 2.03519 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 2.03161 |
| EGR1 | early growth response 1 | 2.02056 |
| GPALPP1 | GPALPP motifs containing 1 | 2.01552 |
| NIT1 | nitrilase 1 | 2.00899 |
| ISCU | iron-sulfur cluster assembly enzyme | 2.00851 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 2.00553 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.00028 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TCTA | T-cell leukemia translocation altered | -7.84525 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -7.33623 |
| COG7 | component of oligomeric golgi complex 7 | -6.63841 |
| HSPB1 | heat shock 27kDa protein 1 | -5.27398 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -5.02349 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -4.97101 |
| CD320 | CD320 molecule | -4.44722 |
| MSMO1 | methylsterol monooxygenase 1 | -4.16132 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -3.80866 |
| TRAP1 | TNF receptor-associated protein 1 | -3.61308 |
| SH3D19 | SH3 domain containing 19 | -3.60445 |
| PRR15L | proline rich 15-like | -3.59177 |
| ANXA2 | annexin A2 | -3.58129 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -3.45828 |
| INSIG1 | insulin induced gene 1 | -3.41478 |
| VDAC1 | voltage-dependent anion channel 1 | -3.4039 |
| CENPX | centromere protein X | -3.37882 |
| SMC1A | structural maintenance of chromosomes 1A | -3.26084 |
| BZW2 | basic leucine zipper and W2 domains 2 | -3.25921 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.25576 |
| EXOSC4 | exosome component 4 | -3.1574 |
| UBFD1 | ubiquitin family domain containing 1 | -3.00886 |
| TKT | transketolase | -2.95021 |
| ATRIP | ATR interacting protein | -2.94886 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.84255 |
| S100A4 | S100 calcium binding protein A4 | -2.8266 |
| CENPM | centromere protein M | -2.81458 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.79376 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.79003 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.72495 |
| TSPAN6 | tetraspanin 6 | -2.72235 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -2.72028 |
| SNRNP25 | small nuclear ribonucleoprotein 25kDa (U11/U12) | -2.71758 |
| TCEA2 | transcription elongation factor A (SII), 2 | -2.69577 |
| DDTL | D-dopachrome tautomerase-like | -2.68818 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.67143 |
| CREB3L4 | cAMP responsive element binding protein 3-like 4 | -2.66948 |
| PUDP | pseudouridine 5'-phosphatase | -2.66794 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -2.64053 |
| MRPL12 | mitochondrial ribosomal protein L12 | -2.6321 |
| SHROOM2 | shroom family member 2 | -2.61591 |
| CD58 | CD58 molecule | -2.58478 |
| PAGR1 | PAXIP1 associated glutamate-rich protein 1 | -2.58242 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -2.56429 |
| KDM5C | lysine (K)-specific demethylase 5C | -2.52353 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -2.52078 |
| RNF40 | ring finger protein 40, E3 ubiquitin protein ligase | -2.48953 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -2.48803 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | -2.46568 |
| LAS1L | LAS1-like (S. cerevisiae) | -2.46282 |
| DHCR24 | 24-dehydrocholesterol reductase | -2.43684 |
| NUBP2 | nucleotide binding protein 2 | -2.42546 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -2.42542 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -2.41057 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | -2.39564 |
| COA3 | cytochrome c oxidase assembly factor 3 | -2.39494 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.39112 |
| BID | BH3 interacting domain death agonist | -2.36819 |
| MAPKAPK3 | mitogen-activated protein kinase-activated protein kinase 3 | -2.35265 |
| CCNB2 | cyclin B2 | -2.35016 |
| MVP | major vault protein | -2.34645 |
| NFIL3 | nuclear factor, interleukin 3 regulated | -2.3441 |
| C1QBP | complement component 1, q subcomponent binding protein | -2.34067 |
| GPS1 | G protein pathway suppressor 1 | -2.34007 |
| DCTN5 | dynactin 5 (p25) | -2.3362 |
| ADNP | activity-dependent neuroprotector homeobox | -2.31733 |
| ACTN4 | actinin, alpha 4 | -2.31372 |
| SPPL2A | signal peptide peptidase like 2A | -2.29978 |
| TTLL12 | tubulin tyrosine ligase-like family member 12 | -2.29 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | -2.28296 |
| PLK1 | polo-like kinase 1 | -2.27789 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | -2.27212 |
| PFN1 | profilin 1 | -2.26564 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | -2.25409 |
| ATP13A1 | ATPase type 13A1 | -2.23732 |
| HSBP1 | heat shock factor binding protein 1 | -2.23536 |
| FBXO34 | F-box protein 34 | -2.22954 |
| H2BC5 | H2B clustered histone 5 | -2.22753 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 | -2.22049 |
| PRMT1 | protein arginine methyltransferase 1 | -2.21415 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -2.21406 |
| BCL7C | B-cell CLL/lymphoma 7C | -2.1858 |
| UPF1 | UPF1 regulator of nonsense transcripts homolog (yeast) | -2.18001 |
| SKAP2 | src kinase associated phosphoprotein 2 | -2.16742 |
| ACLY | ATP citrate lyase | -2.16728 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -2.15858 |
| ARHGAP17 | Rho GTPase activating protein 17 | -2.15469 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | -2.14898 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | -2.14766 |
| PSMB6 | proteasome (prosome, macropain) subunit, beta type, 6 | -2.14631 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.14131 |
| OXSR1 | oxidative stress responsive 1 | -2.13734 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | -2.13173 |
| H2AC19 | H2A clustered histone 19 | -2.12915 |
| ABCF3 | ATP-binding cassette, sub-family F (GCN20), member 3 | -2.12716 |
| DNAAF5 | dynein, axonemal, assembly factor 5 | -2.12584 |
| ACACA | acetyl-CoA carboxylase alpha | -2.12121 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -2.11987 |
| GEMIN6 | gem (nuclear organelle) associated protein 6 | -2.11431 |
| PCNT | pericentrin | -2.11177 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | -2.10655 |
| SAMM50 | SAMM50 sorting and assembly machinery component | -2.10481 |
| XKR8 | XK, Kell blood group complex subunit-related family, member 8 | -2.09156 |
| TLR3 | toll-like receptor 3 | -2.08641 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -2.08088 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -2.08061 |
| NCKIPSD | NCK interacting protein with SH3 domain | -2.08052 |
| SRRM1 | serine/arginine repetitive matrix 1 | -2.07993 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | -2.06456 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | -2.06185 |
| HMGXB3 | HMG box domain containing 3 | -2.05221 |
| HOXA5 | homeobox A5 | -2.04821 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.04392 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -2.0379 |
| MEN1 | multiple endocrine neoplasia I | -2.03769 |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F | -2.03307 |
| CCNB1 | cyclin B1 | -2.0296 |
| SCARB1 | scavenger receptor class B, member 1 | -2.02701 |
| ADI1 | acireductone dioxygenase 1 | -2.02676 |
| HELZ | helicase with zinc finger | -2.01659 |
| RBM10 | RNA binding motif protein 10 | -2.01283 |
