CRCGN016_MCF10A.TP53.M_24H:P13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitro-o-anisidine 99.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

147 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.18046
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.88314
CXCR4 chemokine (C-X-C motif) receptor 4 4.73888
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.5867
AGR2 anterior gradient 2 4.55878
ACAA1 acetyl-CoA acyltransferase 1 4.15042
KDM5D lysine (K)-specific demethylase 5D 4.01498
ADRB2 adrenoceptor beta 2, surface 3.4535
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.44263
VAMP5 vesicle-associated membrane protein 5 3.16493
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 3.1362
CADM1 cell adhesion molecule 1 3.03091
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.02096
MAP7 microtubule-associated protein 7 2.98491
COMP cartilage oligomeric matrix protein 2.96746
VGLL4 vestigial-like family member 4 2.92673
CD69 CD69 molecule 2.87121
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.79427
ZFY zinc finger protein, Y-linked 2.71929
PRELID3B PRELI domain containing 3B 2.65301
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.64707
DPH2 DPH2 homolog (S. cerevisiae) 2.64221
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.63906
TP53I3 tumor protein p53 inducible protein 3 2.6253
CCNA1 cyclin A1 2.58924
IBSP integrin-binding sialoprotein 2.56566
ACLY ATP citrate lyase 2.51287
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.47708
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.46282
ZFHX3 zinc finger homeobox 3 2.43024
TULP4 tubby like protein 4 2.4272
DRAM1 DNA-damage regulated autophagy modulator 1 2.39057
DUOX1 dual oxidase 1 2.3768
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.34223
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.34084
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.31657
SMIM5 small integral membrane protein 5 2.31486
ZFC3H1 zinc finger, C3H1-type containing 2.27356
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2673
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.25583
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.24588
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.2417
DVL3 dishevelled segment polarity protein 3 2.23884
REV1 REV1, polymerase (DNA directed) 2.23468
GPR171 G protein-coupled receptor 171 2.2222
PRPF39 pre-mRNA processing factor 39 2.2087
USP9Y ubiquitin specific peptidase 9, Y-linked 2.20154
VRK1 vaccinia related kinase 1 2.19908
LOC128966597 MAL-like protein 2.19531
MYRIP myosin VIIA and Rab interacting protein 2.1859
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.18318
NADSYN1 NAD synthetase 1 2.17428
FNBP4 formin binding protein 4 2.16258
NKX2-1 NK2 homeobox 1 2.1587
PEX11B peroxisomal biogenesis factor 11 beta 2.14838
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 2.13694
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.13677
NT5C2 5'-nucleotidase, cytosolic II 2.11085
CD8A CD8a molecule 2.11063
EMILIN1 elastin microfibril interfacer 1 2.10876
UNC5B unc-5 homolog B (C. elegans) 2.10624
MCM9 minichromosome maintenance complex component 9 2.09402
ASF1A anti-silencing function 1A histone chaperone 2.08779
NEMF nuclear export mediator factor 2.067
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.06385
VSTM4 V-set and transmembrane domain containing 4 2.05324
SNAI1 snail family zinc finger 1 2.04862
DCPH1 damage control phosphatase 1 2.04796
SATB1 SATB homeobox 1 2.04451
TBPL1 TBP-like 1 2.0388
TRIM22 tripartite motif containing 22 2.03389
TFCP2L1 transcription factor CP2-like 1 2.03356
NCOA4 nuclear receptor coactivator 4 2.03163
ACBD4 acyl-CoA binding domain containing 4 2.03112
TRMT61B tRNA methyltransferase 61B 2.0248
ATP5MJ ATP synthase membrane subunit j 2.02432
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.0238
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.01851
LINC02762 long intergenic non-protein coding RNA 2762 2.01773
NABP2 nucleic acid binding protein 2 2.00661

decreased expression

Symbol Name Standardized Value
C2CD5 C2 calcium-dependent domain containing 5 -9.42262
KRT14 keratin 14, type I -6.3028
PUF60 poly-U binding splicing factor 60KDa -5.1113
PMM2 phosphomannomutase 2 -4.90605
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.89263
SCYL3 SCY1-like 3 (S. cerevisiae) -4.85986
HMG20B high mobility group 20B -4.74133
CCDC86 coiled-coil domain containing 86 -4.47173
PRPF4 pre-mRNA processing factor 4 -4.35353
GTPBP8 GTP-binding protein 8 (putative) -4.18541
SNCA synuclein, alpha (non A4 component of amyloid precursor) -4.02698
NUSAP1 nucleolar and spindle associated protein 1 -3.75475
CANT1 calcium activated nucleotidase 1 -3.23273
CD81 CD81 molecule -3.19581
PHC1 polyhomeotic homolog 1 (Drosophila) -3.03102
ETNK1 ethanolamine kinase 1 -2.97034
UBA1 ubiquitin-like modifier activating enzyme 1 -2.90261
SMC1A structural maintenance of chromosomes 1A -2.90099
PBX3 pre-B-cell leukemia homeobox 3 -2.86338
MSN moesin -2.64256
RAB38 RAB38, member RAS oncogene family -2.63866
PUDP pseudouridine 5'-phosphatase -2.52692
ZXDC ZXD family zinc finger C -2.52576
RIC8A RIC8 guanine nucleotide exchange factor A -2.52
KXD1 KxDL motif containing 1 -2.49959
NANOG Nanog homeobox -2.48843
CA2 carbonic anhydrase II -2.44161
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.40882
ARID5A AT rich interactive domain 5A (MRF1-like) -2.39462
CAMK1 calcium/calmodulin-dependent protein kinase I -2.39159
RNF4 ring finger protein 4 -2.38403
CA9 carbonic anhydrase IX -2.37478
PIH1D1 PIH1 domain containing 1 -2.31957
TUBB4B tubulin, beta 4B class IVb -2.29101
LEFTY2 left-right determination factor 2 -2.28685
FAM193A family with sequence similarity 193, member A -2.27857
TAC4 tachykinin 4 (hemokinin) -2.2605
MFSD12 major facilitator superfamily domain containing 12 -2.25403
GPR143 G protein-coupled receptor 143 -2.24787
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.23607
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.22828
KDM6A lysine (K)-specific demethylase 6A -2.20642
SPATA6 spermatogenesis associated 6 -2.20586
PLEKHO2 pleckstrin homology domain containing, family O member 2 -2.18646
PCCB propionyl CoA carboxylase, beta polypeptide -2.18022
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 -2.1778
CARS1 cysteinyl-tRNA synthetase 1 -2.1623
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.13935
GSPT2 G1 to S phase transition 2 -2.13662
ISYNA1 inositol-3-phosphate synthase 1 -2.13238
ZIC3 Zic family member 3 -2.12771
GRB14 growth factor receptor-bound protein 14 -2.11711
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.11091
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.09658
WDR41 WD repeat domain 41 -2.09503
MLANA melan-A -2.0819
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.08058
DCPS decapping enzyme, scavenger -2.06604
PRPF19 pre-mRNA processing factor 19 -2.06111
BAG6 BCL2-associated athanogene 6 -2.05681
YJU2 YJU2 splicing factor homolog -2.05295
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.02683
ALX1 ALX homeobox 1 -2.02542
USP9X ubiquitin specific peptidase 9, X-linked -2.02271
HBG1 hemoglobin, gamma A -2.01963
SUCO SUN domain containing ossification factor -2.01075
DCLK1 doublecortin-like kinase 1 -2.01043