CRCGN016_MCF10A.TP53.M_24H:P19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 101.04 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:P19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 4.4738
INTS3 integrator complex subunit 3 4.3663
GATA2 GATA binding protein 2 3.66345
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.28337
PTK7 protein tyrosine kinase 7 (inactive) 2.38295
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.3083
SFTPC surfactant protein C 2.30008
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.28995
MARCO macrophage receptor with collagenous structure 2.2793
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.2611
GLO1 glyoxalase I 2.2596
HPGDS hematopoietic prostaglandin D synthase 2.2394
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.2031
RBKS ribokinase 2.1828
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.1577
RAB32 RAB32, member RAS oncogene family 2.118
CDK7 cyclin-dependent kinase 7 2.0919
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.00365
MCUR1 mitochondrial calcium uniporter regulator 1 2.00165

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -5.4085
PCCB propionyl CoA carboxylase, beta polypeptide -5.26375
RPIA ribose 5-phosphate isomerase A -5.0
NPDC1 neural proliferation, differentiation and control, 1 -4.96115
ENOPH1 enolase-phosphatase 1 -4.78675
NLRP4 NLR family, pyrin domain containing 4 -3.94745
CANT1 calcium activated nucleotidase 1 -3.52355
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.47207
IPO13 importin 13 -3.02805
MT1X metallothionein 1X -2.9183
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.57945
BLCAP bladder cancer associated protein -2.53445
DCK deoxycytidine kinase -2.50125
APOLD1 apolipoprotein L domain containing 1 -2.41075
BASP1 brain abundant, membrane attached signal protein 1 -2.40735
STXBP2 syntaxin binding protein 2 -2.35465
TBC1D16 TBC1 domain family, member 16 -2.2172
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.20745
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.14895
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.1149
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.04625
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.01097