CRCGN016_MCF10A.WT.HP_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.06175
CXCR4 chemokine (C-X-C motif) receptor 4 3.80016
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.23796
TBX2 T-box 2 3.14968
FSD1 fibronectin type III and SPRY domain containing 1 2.87491
MMP2 matrix metallopeptidase 2 2.78177
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.60339
MEF2C myocyte enhancer factor 2C 2.53605
TMEM39B transmembrane protein 39B 2.49262
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.47222
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 2.47133
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.46079
MAP2K5 mitogen-activated protein kinase kinase 5 2.45176
EDN1 endothelin 1 2.40787
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.39942
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.35193
PMM2 phosphomannomutase 2 2.28245
UGT8 UDP glycosyltransferase 8 2.25215
C4BPA complement component 4 binding protein, alpha 2.24452
IL7 interleukin 7 2.22658
TTC23 tetratricopeptide repeat domain 23 2.22433
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.20056
MEN1 multiple endocrine neoplasia I 2.19795
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.1754
CLIC2 chloride intracellular channel 2 2.17383
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 2.16263
TMSB15B thymosin beta 15B 2.15691
CCL11 chemokine (C-C motif) ligand 11 2.1435
LAP3 leucine aminopeptidase 3 2.12299
GUCA2A guanylate cyclase activator 2A (guanylin) 2.11457
TCF21 transcription factor 21 2.10522
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.09554
RAB21 RAB21, member RAS oncogene family 2.08684
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 2.08079
MRGBP MRG/MORF4L binding protein 2.07277
ADAMDEC1 ADAM-like, decysin 1 2.05993
LTBP4 latent transforming growth factor beta binding protein 4 2.05849
MEST mesoderm specific transcript 2.05309
NID1 nidogen 1 2.04702
NSF N-ethylmaleimide-sensitive factor 2.04436
TMPRSS2 transmembrane protease, serine 2 2.02333
ADTRP androgen-dependent TFPI-regulating protein 2.01829

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -6.52191
SLC25A46 solute carrier family 25, member 46 -5.29217
UFM1 ubiquitin-fold modifier 1 -5.13061
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.68786
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.63322
MSMO1 methylsterol monooxygenase 1 -4.50651
KDM3A lysine (K)-specific demethylase 3A -3.86746
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.68473
BASP1 brain abundant, membrane attached signal protein 1 -3.37213
KIF20A kinesin family member 20A -3.19192
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.02896
RPS5 ribosomal protein S5 -2.93553
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.82874
STAT1 signal transducer and activator of transcription 1, 91kDa -2.55935
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.55856
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.55513
PROSER1 proline and serine rich 1 -2.55172
CAB39 calcium binding protein 39 -2.44069
COX6C cytochrome c oxidase subunit VIc -2.2833
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.21927
TMEM267 transmembrane protein 267 -2.21715
EXOSC8 exosome component 8 -2.17729
PFN1 profilin 1 -2.15385
LIPG lipase, endothelial -2.13576
LCN2 lipocalin 2 -2.11549
PAIP1 poly(A) binding protein interacting protein 1 -2.08112
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.07515
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.07375
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.06383
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.06231
ANXA2 annexin A2 -2.05768
HLA-C major histocompatibility complex, class I, C -2.01422
B2M beta-2-microglobulin -2.01026
S100A8 S100 calcium binding protein A8 -2.00773