CRCGN016_MCF10A.WT.HP_24H:A08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',3,5',6-pentachloro-1,1'-biphenyl 32.71 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:A08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 4.71795
LOXL1 lysyl oxidase-like 1 4.10357
COMP cartilage oligomeric matrix protein 2.95946
FGFR4 fibroblast growth factor receptor 4 2.75667
AGR2 anterior gradient 2 2.5477
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.40038
IGFBP3 insulin-like growth factor binding protein 3 2.3722
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.24026
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.20551
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.10061
PUM3 pumilio RNA binding family member 3 2.04807

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -3.90419
GDF15 growth differentiation factor 15 -3.39545
DIPK1A divergent protein kinase domain 1A -3.32858
HMG20B high mobility group 20B -3.30018
RPA3 replication protein A3, 14kDa -2.79997
CCNB1 cyclin B1 -2.62255
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.24737
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.24563
CTPS2 CTP synthase 2 -2.23006
XPO7 exportin 7 -2.22161
KDM3A lysine (K)-specific demethylase 3A -2.11533
APOO apolipoprotein O -2.03338