CRCGN016_MCF10A.WT.HP_24H:A12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-benzyl 2-butyl phthalate 11.28 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:A12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 5.30338
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.03693
ADGRE5 adhesion G protein-coupled receptor E5 5.02296
STAP2 signal transducing adaptor family member 2 4.95792
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.91585
FKBP14 FK506 binding protein 14, 22 kDa 4.85401
ARID5B AT rich interactive domain 5B (MRF1-like) 4.66163
SPAG4 sperm associated antigen 4 4.59112
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 4.55317
OLFML2B olfactomedin-like 2B 3.71888
IGHMBP2 immunoglobulin mu binding protein 2 3.49584
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.24986
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.96641
NUTF2 nuclear transport factor 2 2.87134
MTFR1 mitochondrial fission regulator 1 2.74548
STAMBP STAM binding protein 2.6264
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.56212
MDM4 MDM4, p53 regulator 2.55445
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.52881
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.50336
GET1 guided entry of tail-anchored proteins factor 1 2.48725
TMPRSS11D transmembrane protease, serine 11D 2.37946
RLIM ring finger protein, LIM domain interacting 2.32932
SIRT3 sirtuin 3 2.32585
TWSG1 twisted gastrulation BMP signaling modulator 1 2.32239
RBBP5 retinoblastoma binding protein 5 2.27957
TXNL4B thioredoxin-like 4B 2.26512
AGR2 anterior gradient 2 2.25722
THRAP3 thyroid hormone receptor associated protein 3 2.22198
SBNO1 strawberry notch homolog 1 (Drosophila) 2.20061
HDAC2 histone deacetylase 2 2.19663
HOXC6 homeobox C6 2.18871
MTA2 metastasis associated 1 family, member 2 2.15795
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.11986
POMK protein-O-mannose kinase 2.11761
CTSZ cathepsin Z 2.11204
IFITM3 interferon induced transmembrane protein 3 2.11071
IFITM2 interferon induced transmembrane protein 2 2.07015
TMEM101 transmembrane protein 101 2.04382

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -5.86742
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.19798
GDF15 growth differentiation factor 15 -4.81989
CCNB1 cyclin B1 -4.7477
PCCB propionyl CoA carboxylase, beta polypeptide -4.47453
MELK maternal embryonic leucine zipper kinase -3.085
HAGH hydroxyacylglutathione hydrolase -2.89173
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.85786
TCEAL2 transcription elongation factor A (SII)-like 2 -2.76603
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.76268
DHPS deoxyhypusine synthase -2.70555
KDM3A lysine (K)-specific demethylase 3A -2.67149
HIRIP3 HIRA interacting protein 3 -2.66732
ZNF500 zinc finger protein 500 -2.64876
BFAR bifunctional apoptosis regulator -2.57983
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -2.34596
STXBP2 syntaxin binding protein 2 -2.2985
RAB33A RAB33A, member RAS oncogene family -2.29577
ZNF263 zinc finger protein 263 -2.26041
ECHDC2 enoyl CoA hydratase domain containing 2 -2.25274
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.23183
CBLIF cobalamin binding intrinsic factor -2.22899
MUC6 mucin 6, oligomeric mucus/gel-forming -2.17637
METTL22 methyltransferase like 22 -2.16989
SCAMP5 secretory carrier membrane protein 5 -2.16187
PCDHA9 protocadherin alpha 9 -2.147
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.13731
MT1X metallothionein 1X -2.13714
TRIM36 tripartite motif containing 36 -2.12016
SOX3 SRY (sex determining region Y)-box 3 -2.10353
MPHOSPH8 M-phase phosphoprotein 8 -2.0879
ATP4B ATPase, H+/K+ exchanging, beta polypeptide -2.08082
LIPF lipase, gastric -2.07946
METTL25B methyltransferase like 25B -2.06656
CSHL1 chorionic somatomammotropin hormone-like 1 -2.06541
BEX4 brain expressed, X-linked 4 -2.0537
KCTD13 potassium channel tetramerization domain containing 13 -2.05026
BPHL biphenyl hydrolase-like (serine hydrolase) -2.04974
TMEM268 transmembrane protein 268 -2.04861
PRKCQ protein kinase C, theta -2.04531
BOLA1 bolA family member 1 -2.04253
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.03552
GSPT2 G1 to S phase transition 2 -2.02308
AP1M2 adaptor-related protein complex 1, mu 2 subunit -2.01971
ADAT1 adenosine deaminase, tRNA-specific 1 -2.0072
SH3GL2 SH3-domain GRB2-like 2 -2.00238
TOX3 TOX high mobility group box family member 3 -2.00228