CRCGN016_MCF10A.WT.HP_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',4,4',5,5'-hexachloro-1,1'-biphenyl 10.95 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 9.52218
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.9858
AGR2 anterior gradient 2 4.2262
WDR7 WD repeat domain 7 3.76831
CNRIP1 cannabinoid receptor interacting protein 1 3.71894
AXIN1 axin 1 3.45753
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.28985
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.73681
DENND2D DENN/MADD domain containing 2D 2.72279
NKAPD1 NKAP domain containing 1 2.46392
TXNL1 thioredoxin-like 1 2.37317
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.25187
RWDD2B RWD domain containing 2B 2.1814
TERF2 telomeric repeat binding factor 2 2.16688
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.15484
CCNA1 cyclin A1 2.1373
ZBTB35 zinc finger and BTB domain containing 35 2.12566
SRFBP1 serum response factor binding protein 1 2.1203

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.42265
PLK1 polo-like kinase 1 -5.19315
NUP85 nucleoporin 85kDa -5.02672
HMG20B high mobility group 20B -4.37461
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.37349
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.13011
TMEM94 transmembrane protein 94 -3.4891
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.22498
SAP30BP SAP30 binding protein -3.18846
KCTD2 potassium channel tetramerization domain containing 2 -3.06275
MRPS7 mitochondrial ribosomal protein S7 -3.03011
MRPL58 mitochondrial ribosomal protein L58 -2.92118
ACAA1 acetyl-CoA acyltransferase 1 -2.85525
CANT1 calcium activated nucleotidase 1 -2.83088
SLC38A12 solute carrier family 38 member 12 -2.67879
WBP2 WW domain binding protein 2 -2.64234
BPHL biphenyl hydrolase-like (serine hydrolase) -2.56345
CASKIN2 CASK interacting protein 2 -2.55572
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.53284
RAI14 retinoic acid induced 14 -2.3264
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.22324
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.21034
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.19983
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.14009
ECHDC3 enoyl CoA hydratase domain containing 3 -2.13196
FNDC4 fibronectin type III domain containing 4 -2.07245
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.05261
MSMO1 methylsterol monooxygenase 1 -2.05011
SUMO4 small ubiquitin-like modifier 4 -2.04992
JPT1 Jupiter microtubule associated homolog 1 -2.04585
MFSD12 major facilitator superfamily domain containing 12 -2.03792
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.03545
MMP17 matrix metallopeptidase 17 (membrane-inserted) -2.00675