CRCGN016_MCF10A.WT.HP_24H:A23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description melphalan 32.65 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

253 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:A23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 8.47568
TICAM1 toll-like receptor adaptor molecule 1 5.93521
DDB2 damage-specific DNA binding protein 2, 48kDa 5.22619
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.85735
RGS2 regulator of G-protein signaling 2 4.73518
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.47827
INPP1 inositol polyphosphate-1-phosphatase 4.12271
MUC1 mucin 1, cell surface associated 4.06495
NOTCH1 notch 1 4.03024
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.85016
LRP10 low density lipoprotein receptor-related protein 10 3.78861
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.65359
TCEA2 transcription elongation factor A (SII), 2 3.58499
FDXR ferredoxin reductase 3.18941
STAP2 signal transducing adaptor family member 2 3.15653
ADAM10 ADAM metallopeptidase domain 10 3.11457
GARRE1 granule associated Rac and RHOG effector 1 3.08786
SAMD9 sterile alpha motif domain containing 9 3.08429
MX1 MX dynamin-like GTPase 1 3.05148
DUSP14 dual specificity phosphatase 14 3.03677
MVP major vault protein 2.94576
REEP2 receptor accessory protein 2 2.89084
ITFG1 integrin alpha FG-GAP repeat containing 1 2.88159
LCAT lecithin-cholesterol acyltransferase 2.82164
CES2 carboxylesterase 2 2.79107
IRF9 interferon regulatory factor 9 2.76324
SESN1 sestrin 1 2.75856
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.74143
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.67787
NISCH nischarin 2.64889
ADRB2 adrenoceptor beta 2, surface 2.64431
CAPN1 calpain 1, (mu/I) large subunit 2.63769
DGKA diacylglycerol kinase, alpha 80kDa 2.61339
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.59803
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.59463
TRIM22 tripartite motif containing 22 2.5858
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.56512
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.535
DSG3 desmoglein 3 2.52564
TGM1 transglutaminase 1 2.52092
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.51394
MINDY1 MINDY lysine 48 deubiquitinase 1 2.50415
RUSC2 RUN and SH3 domain containing 2 2.46049
TIAM1 T-cell lymphoma invasion and metastasis 1 2.45731
ISG15 ISG15 ubiquitin-like modifier 2.45019
ECM1 extracellular matrix protein 1 2.43041
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.4293
CDIP1 cell death-inducing p53 target 1 2.42845
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.42836
TBXA2R thromboxane A2 receptor 2.40798
KRT16 keratin 16, type I 2.40562
GRN granulin 2.38005
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.37375
MZT2A mitotic spindle organizing protein 2A 2.37036
TP53I3 tumor protein p53 inducible protein 3 2.36731
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.36723
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.3667
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.33544
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.332
INKA2 inka box actin regulator 2 2.33078
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.31935
EPN2 epsin 2 2.31565
BAX BCL2-associated X protein 2.30145
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.29176
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.28998
MARCHF2 membrane associated ring-CH-type finger 2 2.28371
RTP4 receptor (chemosensory) transporter protein 4 2.28234
EML2 echinoderm microtubule associated protein like 2 2.27193
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.27113
NOP10 NOP10 ribonucleoprotein 2.26931
LAMA5 laminin, alpha 5 2.26581
FHL2 four and a half LIM domains 2 2.25836
AGR2 anterior gradient 2 2.25396
OASL 2'-5'-oligoadenylate synthetase-like 2.2433
COPZ2 coatomer protein complex, subunit zeta 2 2.21825
PDIA2 protein disulfide isomerase family A, member 2 2.21639
LMF2 lipase maturation factor 2 2.21548
EPHA1 EPH receptor A1 2.21402
STXBP1 syntaxin binding protein 1 2.21347
ZDHHC11B zinc finger, DHHC-type containing 11B 2.20555
PLK3 polo-like kinase 3 2.2015
TNS4 tensin 4 2.19072
MICALL1 MICAL-like 1 2.1771
TPST2 tyrosylprotein sulfotransferase 2 2.17086
EPHA2 EPH receptor A2 2.17055
METRN meteorin, glial cell differentiation regulator 2.16967
SPRR1B small proline-rich protein 1B 2.16823
NPFFR1 neuropeptide FF receptor 1 2.16763
SAMD14 sterile alpha motif domain containing 14 2.16471
MXRA5 matrix-remodelling associated 5 2.15718
TRIM45 tripartite motif containing 45 2.15524
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.15025
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 2.14712
AEN apoptosis enhancing nuclease 2.14623
ITM2B integral membrane protein 2B 2.14611
APOL2 apolipoprotein L, 2 2.13684
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 2.13101
AMOTL2 angiomotin like 2 2.12783
KRT6A keratin 6A, type II 2.12739
LCN1 lipocalin 1 2.1164
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.1095
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.10895
DDTL D-dopachrome tautomerase-like 2.10693
E2F2 E2F transcription factor 2 2.10069
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.09332
TOB1 transducer of ERBB2, 1 2.09162
MUC13 mucin 13, cell surface associated 2.08926
MX2 MX dynamin-like GTPase 2 2.0843
IFI6 interferon, alpha-inducible protein 6 2.08365
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.07595
GJB5 gap junction protein, beta 5, 31.1kDa 2.06721
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.06632
SPEG SPEG complex locus 2.06134
EPHX3 epoxide hydrolase 3 2.05323
ABHD4 abhydrolase domain containing 4 2.05099
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.04964
BBC3 BCL2 binding component 3 2.04704
PYCARD PYD and CARD domain containing 2.04701
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.04528
PDK2 pyruvate dehydrogenase kinase, isozyme 2 2.04469
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.02972
CLTB clathrin, light chain B 2.0272
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.02637
SUGCT succinyl-CoA:glutarate-CoA transferase 2.01358
SPRR1A small proline-rich protein 1A 2.00941
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.00823
ZMAT3 zinc finger, matrin-type 3 2.00797
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.00594
IVL involucrin 2.00548
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.0005

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.88042
PSRC1 proline/serine-rich coiled-coil 1 -7.33155
UBE2C ubiquitin-conjugating enzyme E2C -6.99867
PLK1 polo-like kinase 1 -6.5974
KIF20A kinesin family member 20A -6.09455
CCNB2 cyclin B2 -5.63233
THAP11 THAP domain containing 11 -5.21665
AURKA aurora kinase A -5.1701
TOP2A topoisomerase (DNA) II alpha 170kDa -4.95559
ISOC1 isochorismatase domain containing 1 -4.86242
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.65339
KIF14 kinesin family member 14 -3.9934
NCAPD2 non-SMC condensin I complex, subunit D2 -3.94951
DNM1L dynamin 1-like -3.94737
LBR lamin B receptor -3.86356
SCYL3 SCY1-like 3 (S. cerevisiae) -3.77646
BIRC5 baculoviral IAP repeat containing 5 -3.72508
CCNA2 cyclin A2 -3.71674
DEPDC1 DEP domain containing 1 -3.68817
CCNB1 cyclin B1 -3.65479
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.65024
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.51791
CENPA centromere protein A -3.45892
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.43072
ANXA2 annexin A2 -3.40339
CDKN3 cyclin-dependent kinase inhibitor 3 -3.37958
HJURP Holliday junction recognition protein -3.37889
CETN3 centrin, EF-hand protein, 3 -3.36901
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.36586
NUSAP1 nucleolar and spindle associated protein 1 -3.35578
NEK2 NIMA-related kinase 2 -3.28463
CDCA3 cell division cycle associated 3 -3.24037
MTERF3 mitochondrial transcription termination factor 3 -3.1091
KIF4A kinesin family member 4A -3.093
BASP1 brain abundant, membrane attached signal protein 1 -3.08005
BAG3 BCL2-associated athanogene 3 -3.03749
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.03381
CDCA8 cell division cycle associated 8 -3.02074
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.94312
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.94055
SLC25A46 solute carrier family 25, member 46 -2.91352
RACGAP1 Rac GTPase activating protein 1 -2.91209
AURKB aurora kinase B -2.9095
HMGB2 high mobility group box 2 -2.8985
DTD1 D-tyrosyl-tRNA deacylase 1 -2.84045
TPX2 TPX2, microtubule-associated -2.83704
CDK4 cyclin-dependent kinase 4 -2.80234
SUMF2 sulfatase modifying factor 2 -2.78379
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.77817
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.71048
SMYD2 SET and MYND domain containing 2 -2.67819
OIP5 Opa interacting protein 5 -2.6754
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.67465
PIMREG PICALM interacting mitotic regulator -2.65253
TTK TTK protein kinase -2.63077
DDIT4 DNA-damage-inducible transcript 4 -2.59119
TRIB3 tribbles pseudokinase 3 -2.55413
PAK1IP1 PAK1 interacting protein 1 -2.53591
GSTM5 glutathione S-transferase mu 5 -2.49891
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.48732
PLPP3 phospholipid phosphatase 3 -2.45674
CDCA4 cell division cycle associated 4 -2.45296
GIN1 gypsy retrotransposon integrase 1 -2.43691
INTS13 integrator complex subunit 13 -2.4297
NOP16 NOP16 nucleolar protein -2.412
CDC23 cell division cycle 23 -2.40011
CCNF cyclin F -2.39792
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.36729
SAP30 Sin3A-associated protein, 30kDa -2.35612
TCERG1 transcription elongation regulator 1 -2.33619
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.32528
TNIP1 TNFAIP3 interacting protein 1 -2.30884
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.30521
PTTG1 pituitary tumor-transforming 1 -2.30025
CENPF centromere protein F, 350/400kDa -2.29795
UIMC1 ubiquitin interaction motif containing 1 -2.2862
PSPC1 paraspeckle component 1 -2.28349
H2AZ1 H2A.Z variant histone 1 -2.28131
MCM3 minichromosome maintenance complex component 3 -2.27153
MED28 mediator complex subunit 28 -2.26294
COMMD10 COMM domain containing 10 -2.24938
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.24501
KIAA0586 KIAA0586 -2.23728
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.22917
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.22054
PUF60 poly-U binding splicing factor 60KDa -2.21942
ENO1 enolase 1, (alpha) -2.19887
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.19642
TRMT5 tRNA methyltransferase 5 -2.19114
ENOPH1 enolase-phosphatase 1 -2.19083
FBXO5 F-box protein 5 -2.18385
SEC61G Sec61 gamma subunit -2.17707
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.17547
EIF5 eukaryotic translation initiation factor 5 -2.17289
CEP55 centrosomal protein 55kDa -2.1689
FBL fibrillarin -2.1672
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.16077
HMGN2 high mobility group nucleosomal binding domain 2 -2.14093
TACC3 transforming, acidic coiled-coil containing protein 3 -2.13307
ANKRD10 ankyrin repeat domain 10 -2.11723
TTC1 tetratricopeptide repeat domain 1 -2.11346
UBE2S ubiquitin-conjugating enzyme E2S -2.11087
HDAC2 histone deacetylase 2 -2.10796
MRPL19 mitochondrial ribosomal protein L19 -2.10723
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.09802
SEC63 SEC63 homolog (S. cerevisiae) -2.09715
MAT2B methionine adenosyltransferase II, beta -2.09232
AFG3L2 AFG3-like AAA ATPase 2 -2.08957
ZNF184 zinc finger protein 184 -2.08933
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.06937
DBF4 DBF4 zinc finger -2.06735
RESF1 retroelement silencing factor 1 -2.05953
CHKA choline kinase alpha -2.0564
MOCS2 molybdenum cofactor synthesis 2 -2.05228
EIF4E eukaryotic translation initiation factor 4E -2.04512
AVL9 AVL9 homolog (S. cerevisiase) -2.042
EBNA1BP2 EBNA1 binding protein 2 -2.02369
KTN1 kinectin 1 (kinesin receptor) -2.02171
SEH1L SEH1-like (S. cerevisiae) -2.00978
CUTC cutC copper transporter -2.0091
FOXM1 forkhead box M1 -2.00731
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.00653
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 -2.001