CRCGN016_MCF10A.WT.HP_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description melphalan 10.88 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

110 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.92171
AGR2 anterior gradient 2 4.67273
NOTCH1 notch 1 3.90105
DDB2 damage-specific DNA binding protein 2, 48kDa 3.87631
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.64196
RGS2 regulator of G-protein signaling 2 3.56125
LRP10 low density lipoprotein receptor-related protein 10 3.35659
SQOR sulfide quinone oxidoreductase 3.24245
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.2007
STK10 serine/threonine kinase 10 3.18463
GADD45A growth arrest and DNA-damage-inducible, alpha 3.12763
INPP1 inositol polyphosphate-1-phosphatase 2.99073
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.91983
KDM5D lysine (K)-specific demethylase 5D 2.89907
TICAM1 toll-like receptor adaptor molecule 1 2.85023
RBKS ribokinase 2.78445
MINDY1 MINDY lysine 48 deubiquitinase 1 2.76954
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.7394
S100A4 S100 calcium binding protein A4 2.71877
FGFR4 fibroblast growth factor receptor 4 2.67092
STAP2 signal transducing adaptor family member 2 2.65567
SESN1 sestrin 1 2.62993
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.61489
ADRB2 adrenoceptor beta 2, surface 2.52535
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.50743
DUSP14 dual specificity phosphatase 14 2.44735
TCEA2 transcription elongation factor A (SII), 2 2.41664
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.3577
RND1 Rho family GTPase 1 2.34533
TCEAL4 transcription elongation factor A (SII)-like 4 2.31583
GRN granulin 2.26249
CHIC2 cysteine-rich hydrophobic domain 2 2.25424
DES desmin 2.23281
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.22036
RAB17 RAB17, member RAS oncogene family 2.2099
UROS uroporphyrinogen III synthase 2.10909
YPEL5 yippee-like 5 (Drosophila) 2.10368
PYCARD PYD and CARD domain containing 2.08904
MICALL1 MICAL-like 1 2.07071
BAX BCL2-associated X protein 2.06658
TCEAL1 transcription elongation factor A (SII)-like 1 2.04901
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.04697
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.04167
TDRD7 tudor domain containing 7 2.03032
CCDC92 coiled-coil domain containing 92 2.02804

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.79865
KIF14 kinesin family member 14 -5.74882
PSRC1 proline/serine-rich coiled-coil 1 -5.06073
KIF20A kinesin family member 20A -4.94553
ARID4B AT rich interactive domain 4B (RBP1-like) -4.06053
PLK1 polo-like kinase 1 -3.71115
NCAPD2 non-SMC condensin I complex, subunit D2 -3.51052
LYPLA1 lysophospholipase I -3.36556
MT1X metallothionein 1X -3.14559
NUSAP1 nucleolar and spindle associated protein 1 -3.08925
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.02997
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.95845
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.95793
AURKB aurora kinase B -2.91914
RXYLT1 ribitol xylosyltransferase 1 -2.90132
FAIM Fas apoptotic inhibitory molecule -2.80869
KRT14 keratin 14, type I -2.78757
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.78628
UBE2C ubiquitin-conjugating enzyme E2C -2.77504
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.75535
LBR lamin B receptor -2.68434
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.66197
NOP16 NOP16 nucleolar protein -2.63916
CDCA3 cell division cycle associated 3 -2.62431
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.50731
CETN3 centrin, EF-hand protein, 3 -2.48395
TOP2A topoisomerase (DNA) II alpha 170kDa -2.37684
CDKN3 cyclin-dependent kinase inhibitor 3 -2.36653
CCNB2 cyclin B2 -2.36183
DEPDC1 DEP domain containing 1 -2.34867
SEC63 SEC63 homolog (S. cerevisiae) -2.3205
UBA1 ubiquitin-like modifier activating enzyme 1 -2.31584
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.30986
CBR1 carbonyl reductase 1 -2.30842
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.29228
CCNA2 cyclin A2 -2.29175
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.26722
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.26485
NEK2 NIMA-related kinase 2 -2.2577
ARID4A AT rich interactive domain 4A (RBP1-like) -2.24077
CHRM3 cholinergic receptor, muscarinic 3 -2.22645
CCNB1 cyclin B1 -2.2234
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.21375
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.20631
XPO7 exportin 7 -2.19823
NGRN neugrin, neurite outgrowth associated -2.16869
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.16385
KIF23 kinesin family member 23 -2.14427
PLSCR3 phospholipid scramblase 3 -2.1284
HJURP Holliday junction recognition protein -2.12752
KIF18A kinesin family member 18A -2.12151
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.12045
SMC1A structural maintenance of chromosomes 1A -2.10068
MRPL15 mitochondrial ribosomal protein L15 -2.10004
TMED9 transmembrane emp24 protein transport domain containing 9 -2.08817
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.07999
KIF11 kinesin family member 11 -2.07855
ARHGAP11A Rho GTPase activating protein 11A -2.07406
SQSTM1 sequestosome 1 -2.06699
CHD1 chromodomain helicase DNA binding protein 1 -2.04184
TTK TTK protein kinase -2.04161
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.03819
EGR1 early growth response 1 -2.03107
RB1CC1 RB1-inducible coiled-coil 1 -2.02286
NRF1 nuclear respiratory factor 1 -2.01234