CRCGN016_MCF10A.WT.HP_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3',4,4'-tetrachloro-1,1'-biphenyl 95.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 3.91765
RAB21 RAB21, member RAS oncogene family 3.35931
SCRN1 secernin 1 3.15256
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.83531
RBM6 RNA binding motif protein 6 2.72425
CRELD2 cysteine-rich with EGF-like domains 2 2.68468
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.61759
SPAG4 sperm associated antigen 4 2.46567
ELAC2 elaC ribonuclease Z 2 2.28932
SMIM40 small integral membrane protein 40 2.21108
ZNF318 zinc finger protein 318 2.1526
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.11474
ACAA1 acetyl-CoA acyltransferase 1 2.07743
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.03256

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.8293
PRPF4 pre-mRNA processing factor 4 -3.79309
PCNA proliferating cell nuclear antigen -3.46134
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.32884
HAT1 histone acetyltransferase 1 -3.30092
LYPLA1 lysophospholipase I -2.81338
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.76606
TMEM230 transmembrane protein 230 -2.60627
GADD45G growth arrest and DNA-damage-inducible, gamma -2.56359
RPS5 ribosomal protein S5 -2.55099
RXYLT1 ribitol xylosyltransferase 1 -2.37294
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.24453
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.23291
MSMO1 methylsterol monooxygenase 1 -2.13379
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.10212
YME1L1 YME1-like 1 ATPase -2.07308
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.06028
BAX BCL2-associated X protein -2.02416
MRPS33 mitochondrial ribosomal protein S33 -2.01525
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.01428