CRCGN016_MCF10A.WT.HP_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chrysene 10.36 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

130 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 5.63295
SPAG4 sperm associated antigen 4 4.93325
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.5537
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 4.16907
FZD1 frizzled class receptor 1 3.62038
GSTZ1 glutathione S-transferase zeta 1 3.12125
LGMN legumain 3.04955
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.0463
CDK19 cyclin-dependent kinase 19 2.99787
CCNA1 cyclin A1 2.8568
CADM1 cell adhesion molecule 1 2.8335
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.7827
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.67725
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.63425
ACTC1 actin, alpha, cardiac muscle 1 2.6339
HBB hemoglobin, beta 2.54665
SLN sarcolipin 2.5364
TNNI2 troponin I type 2 (skeletal, fast) 2.52405
KLHL12 kelch-like family member 12 2.47175
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.46205
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.4467
RNF146 ring finger protein 146 2.44565
GREM2 gremlin 2, DAN family BMP antagonist 2.4449
MMRN1 multimerin 1 2.4293
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.386
TMEM123 transmembrane protein 123 2.37275
SMAP1 small ArfGAP 1 2.3505
CASQ2 calsequestrin 2 (cardiac muscle) 2.35035
ACKR3 atypical chemokine receptor 3 2.34815
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.3478
SLC43A3 solute carrier family 43, member 3 2.31652
HLA-DOB major histocompatibility complex, class II, DO beta 2.3086
ACTA1 actin, alpha 1, skeletal muscle 2.29845
IL21R interleukin 21 receptor 2.29628
HHEX hematopoietically expressed homeobox 2.28235
PYGM phosphorylase, glycogen, muscle 2.27425
RBMS3 RNA binding motif, single stranded interacting protein 3 2.2334
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.2282
BCAS4 breast carcinoma amplified sequence 4 2.21895
DOCK3 dedicator of cytokinesis 3 2.21735
APOD apolipoprotein D 2.21715
GSDME gasdermin E 2.21215
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.2083
SERHL2 serine hydrolase-like 2 2.20205
KLHL29 kelch-like family member 29 2.19265
KLHL41 kelch-like family member 41 2.15975
PDLIM3 PDZ and LIM domain 3 2.15205
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.13995
DUOX1 dual oxidase 1 2.12853
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.1263
AKAP12 A kinase (PRKA) anchor protein 12 2.12345
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.10075
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.08745
GRAMD2B GRAM domain containing 2B 2.0762
MYL11 myosin light chain 11 2.07045
TNNC2 troponin C type 2 (fast) 2.0664
CFH complement factor H 2.06557
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.0652
KRT5 keratin 5, type II 2.0589
NUBP2 nucleotide binding protein 2 2.05075
NKX2-1 NK2 homeobox 1 2.04702
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.043
BARD1 BRCA1 associated RING domain 1 2.04165
DGKI diacylglycerol kinase, iota 2.04095
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.0396
MB myoglobin 2.03515
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.0253
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.02397
TNNI1 troponin I type 1 (skeletal, slow) 2.01925
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.01555
FCGBP Fc fragment of IgG binding protein 2.01525
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.01195
WASHC5 WASH complex subunit 5 2.0059

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -10.0
YME1L1 YME1-like 1 ATPase -5.93147
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.27878
FOS FBJ murine osteosarcoma viral oncogene homolog -5.0232
MRPS2 mitochondrial ribosomal protein S2 -4.9947
CHMP4B charged multivesicular body protein 4B -4.90683
HMG20B high mobility group 20B -4.43605
MSMO1 methylsterol monooxygenase 1 -3.853
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.78783
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.7082
MTFR1 mitochondrial fission regulator 1 -3.53175
COQ4 coenzyme Q4 -2.96645
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.95545
ABI1 abl-interactor 1 -2.91585
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.8321
SMC1A structural maintenance of chromosomes 1A -2.79562
ACAA1 acetyl-CoA acyltransferase 1 -2.7302
TRAP1 TNF receptor-associated protein 1 -2.68805
PAEP progestagen-associated endometrial protein -2.68145
WAC WW domain containing adaptor with coiled-coil -2.6106
MATK megakaryocyte-associated tyrosine kinase -2.5815
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.5377
TIMP1 TIMP metallopeptidase inhibitor 1 -2.51855
PDGFC platelet derived growth factor C -2.4855
ZNF189 zinc finger protein 189 -2.4355
LINC02762 long intergenic non-protein coding RNA 2762 -2.40335
EDF1 endothelial differentiation-related factor 1 -2.38718
UBAC1 UBA domain containing 1 -2.3732
GDI2 GDP dissociation inhibitor 2 -2.35497
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.3389
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.3099
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.25
TSPAN3 tetraspanin 3 -2.23802
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.2336
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.19225
FBXO7 F-box protein 7 -2.18835
AGMAT agmatine ureohydrolase (agmatinase) -2.1785
MGST3 microsomal glutathione S-transferase 3 -2.17175
BBS1 Bardet-Biedl syndrome 1 -2.17075
INKA2 inka box actin regulator 2 -2.16975
TLK2 tousled-like kinase 2 -2.16422
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.16335
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.1573
TTC38 tetratricopeptide repeat domain 38 -2.1563
FXN frataxin -2.1323
TOB1 transducer of ERBB2, 1 -2.11985
CBY1 chibby homolog 1 (Drosophila) -2.11945
OARD1 O-acyl-ADP-ribose deacylase 1 -2.1103
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.10445
PROSER1 proline and serine rich 1 -2.08755
SSR1 signal sequence receptor, alpha -2.04897
IFT88 intraflagellar transport 88 -2.0296
PTOV1 prostate tumor overexpressed 1 -2.0259
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.02205
PMPCA peptidase (mitochondrial processing) alpha -2.0178
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.01378
RIDA reactive intermediate imine deaminase A homolog -2.0029