CRCGN016_MCF10A.WT.HP_24H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

304 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 5.13602
TLR4 toll-like receptor 4 4.9898
TLR8 toll-like receptor 8 4.69579
FPR2 formyl peptide receptor 2 4.60372
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.48628
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 4.42051
CRELD2 cysteine-rich with EGF-like domains 2 4.38829
COMP cartilage oligomeric matrix protein 4.16952
GATD3 glutamine amidotransferase class 1 domain containing 3 3.57261
PTPRJ protein tyrosine phosphatase, receptor type, J 3.54907
PFKL phosphofructokinase, liver 3.47324
TRAPPC10 trafficking protein particle complex 10 3.33135
TLR1 toll-like receptor 1 3.27396
IGHMBP2 immunoglobulin mu binding protein 2 3.26112
CCL11 chemokine (C-C motif) ligand 11 3.22926
FBXL6 F-box and leucine-rich repeat protein 6 3.21785
RIPK4 receptor-interacting serine-threonine kinase 4 3.16776
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.15671
NADK NAD kinase 3.14729
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.1331
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 3.1313
TGFB3 transforming growth factor, beta 3 3.09101
GASK1B golgi associated kinase 1B 3.06187
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 2.93824
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.93037
IL1B interleukin 1, beta 2.92401
CCR2 chemokine (C-C motif) receptor 2 2.91463
DTX4 deltex 4, E3 ubiquitin ligase 2.88123
RAG2 recombination activating gene 2 2.8742
MCTP1 multiple C2 domains, transmembrane 1 2.85952
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.80995
TRABD TraB domain containing 2.79279
STX11 syntaxin 11 2.79012
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.7594
PLXNB3 plexin B3 2.74617
CENPB centromere protein B, 80kDa 2.72848
ZEB2 zinc finger E-box binding homeobox 2 2.71174
FMO1 flavin containing monooxygenase 1 2.70958
ZNF12 zinc finger protein 12 2.70829
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.70481
PLXNB2 plexin B2 2.69857
MYLK3 myosin light chain kinase 3 2.69112
ZNF180 zinc finger protein 180 2.69075
TLR6 toll-like receptor 6 2.6882
CAPN15 calpain 15 2.68568
ADGRE2 adhesion G protein-coupled receptor E2 2.66876
NOX4 NADPH oxidase 4 2.63741
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.61097
CRNKL1 crooked neck pre-mRNA splicing factor 1 2.59876
LOC102724560 cystathionine beta-synthase 2.59137
BRWD1 bromodomain and WD repeat domain containing 1 2.58906
RASA3 RAS p21 protein activator 3 2.58303
DENND2A DENN/MADD domain containing 2A 2.57058
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.56243
MTG1 mitochondrial ribosome-associated GTPase 1 2.55099
CLEC4A C-type lectin domain family 4, member A 2.54673
EPYC epiphycan 2.52479
KLHDC3 kelch domain containing 3 2.51903
LAP3 leucine aminopeptidase 3 2.51426
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.50644
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.50555
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.49417
AFAP1 actin filament associated protein 1 2.49064
RTN2 reticulon 2 2.4797
NRBF2 nuclear receptor binding factor 2 2.45736
MYBPC2 myosin binding protein C, fast type 2.454
MILR1 mast cell immunoglobulin-like receptor 1 2.441
CLIP2 CAP-GLY domain containing linker protein 2 2.42484
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.41848
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.40679
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.4067
FPR1 formyl peptide receptor 1 2.39957
ARFRP1 ADP-ribosylation factor related protein 1 2.37837
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.37822
GPR65 G protein-coupled receptor 65 2.36858
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.36776
PBLD phenazine biosynthesis-like protein domain containing 2.35197
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.34665
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.34353
HMHB1 histocompatibility (minor) HB-1 2.34258
SIGLEC9 sialic acid binding Ig-like lectin 9 2.34011
SMC6 structural maintenance of chromosomes 6 2.32985
MINDY2 MINDY lysine 48 deubiquitinase 2 2.32834
SETD4 SET domain containing 4 2.32828
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.32113
BYSL bystin-like 2.31825
ACVR2A activin A receptor, type IIA 2.30956
H2BC21 H2B clustered histone 21 2.3093
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.30779
ANKH ANKH inorganic pyrophosphate transport regulator 2.2998
CD101 CD101 molecule 2.29897
C5AR1 complement component 5a receptor 1 2.29693
STK38 serine/threonine kinase 38 2.29254
ZFYVE16 zinc finger, FYVE domain containing 16 2.28933
ZNF350 zinc finger protein 350 2.28759
ZNF223 zinc finger protein 223 2.28287
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.27867
RYR2 ryanodine receptor 2 (cardiac) 2.27855
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.27842
ZNF227 zinc finger protein 227 2.27802
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.26845
INTS1 integrator complex subunit 1 2.26594
DCTN1 dynactin 1 2.26488
DROSHA drosha, ribonuclease type III 2.26187
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.26052
SMG9 SMG9 nonsense mediated mRNA decay factor 2.26001
SULF1 sulfatase 1 2.25983
ETV7 ets variant 7 2.24904
FBXL12 F-box and leucine-rich repeat protein 12 2.24654
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.24093
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.24093
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.24043
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 2.23941
APOL1 apolipoprotein L, 1 2.23919
OGN osteoglycin 2.22691
CYRIA CYFIP related Rac1 interactor A 2.22666
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.2248
ACAA1 acetyl-CoA acyltransferase 1 2.22478
CTNND1 catenin (cadherin-associated protein), delta 1 2.22402
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.22171
CASS4 Cas scaffolding protein family member 4 2.22105
MED22 mediator complex subunit 22 2.21822
PPP6R2 protein phosphatase 6, regulatory subunit 2 2.21773
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.21754
LOC102723996 ICOS ligand 2.21613
MEST mesoderm specific transcript 2.20852
FCAR Fc fragment of IgA receptor 2.20703
NUAK1 NUAK family, SNF1-like kinase, 1 2.20212
TLN2 talin 2 2.19734
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.19692
CCR3 chemokine (C-C motif) receptor 3 2.19594
MORC3 MORC family CW-type zinc finger 3 2.195
GDF3 growth differentiation factor 3 2.19269
ERCC6 excision repair cross-complementation group 6 2.19006
CDK10 cyclin-dependent kinase 10 2.18699
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.18612
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.18575
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.18074
MUS81 MUS81 structure-specific endonuclease subunit 2.17882
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.17723
TXNL4B thioredoxin-like 4B 2.1747
PARP8 poly (ADP-ribose) polymerase family, member 8 2.16874
PDCD1LG2 programmed cell death 1 ligand 2 2.16838
TJP2 tight junction protein 2 2.16832
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.1631
CCR1 chemokine (C-C motif) receptor 1 2.16226
CLEC5A C-type lectin domain family 5, member A 2.16125
LATS1 large tumor suppressor kinase 1 2.15567
HNMT histamine N-methyltransferase 2.15557
DDR2 discoidin domain receptor tyrosine kinase 2 2.15445
CMTR1 cap methyltransferase 1 2.1479
ZNF480 zinc finger protein 480 2.14
CNOT3 CCR4-NOT transcription complex, subunit 3 2.13858
CDK9 cyclin-dependent kinase 9 2.13628
DNM2 dynamin 2 2.13384
TTLL12 tubulin tyrosine ligase-like family member 12 2.12997
PTPRK protein tyrosine phosphatase, receptor type, K 2.12814
ZNF112 zinc finger protein 112 2.12811
ADGRB2 adhesion G protein-coupled receptor B2 2.12694
GIMAP4 GTPase, IMAP family member 4 2.12416
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.12043
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.11909
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.1188
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.11568
SFRP4 secreted frizzled-related protein 4 2.11479
PCDHB8 protocadherin beta 8 2.11021
NUP42 nucleoporin 42 2.10947
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.10904
SLC12A8 solute carrier family 12, member 8 2.10719
SLC12A9 solute carrier family 12, member 9 2.10608
MGAM maltase-glucoamylase 2.10291
EDC3 enhancer of mRNA decapping 3 2.10238
CXCL11 chemokine (C-X-C motif) ligand 11 2.0993
GLT8D2 glycosyltransferase 8 domain containing 2 2.0992
CD300C CD300c molecule 2.09263
ZFP36L1 ZFP36 ring finger protein-like 1 2.09137
EIF3B eukaryotic translation initiation factor 3, subunit B 2.09113
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.09095
SBF1 SET binding factor 1 2.09084
CAPN5 calpain 5 2.08853
COL8A1 collagen, type VIII, alpha 1 2.08664
FXN frataxin 2.08618
NUP155 nucleoporin 155kDa 2.08471
VPREB1 pre-B lymphocyte 1 2.08218
MTA1 metastasis associated 1 2.07995
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.07967
CDC37 cell division cycle 37 2.07932
ZNF692 zinc finger protein 692 2.07802
ADGRE3 adhesion G protein-coupled receptor E3 2.07199
NFE2L3 nuclear factor, erythroid 2-like 3 2.07144
OGFR opioid growth factor receptor 2.07138
ATP13A2 ATPase type 13A2 2.06934
NOP2 NOP2 nucleolar protein 2.06898
R3HCC1L R3H domain and coiled-coil containing 1-like 2.06812
GPR132 G protein-coupled receptor 132 2.06736
FYB1 FYN binding protein 1 2.06721
KERA keratocan 2.06549
CD96 CD96 molecule 2.06128
SYNJ1 synaptojanin 1 2.05986
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.05963
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.05735
GPR22 G protein-coupled receptor 22 2.05378
NCKIPSD NCK interacting protein with SH3 domain 2.05336
IL24 interleukin 24 2.05291
BNC2 basonuclin 2 2.05181
GCH1 GTP cyclohydrolase 1 2.0507
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.04833
ZNF780A zinc finger protein 780A 2.04746
THBS1 thrombospondin 1 2.04151
CTSE cathepsin E 2.04075
LIPC lipase, hepatic 2.03884
MCM3AP minichromosome maintenance complex component 3 associated protein 2.03574
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.03336
EHBP1L1 EH domain binding protein 1-like 1 2.03111
ADAP1 ArfGAP with dual PH domains 1 2.02606
TLR7 toll-like receptor 7 2.0254
RHOBTB1 Rho-related BTB domain containing 1 2.02539
PTPRB protein tyrosine phosphatase, receptor type, B 2.0225
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 2.01676
PRKG1 protein kinase, cGMP-dependent, type I 2.01363
DNAH17 dynein, axonemal, heavy chain 17 2.01271
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.01017
ZNF37A zinc finger protein 37A 2.00855
CCRL2 chemokine (C-C motif) receptor-like 2 2.00575
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2.00546
OSBPL11 oxysterol binding protein-like 11 2.00118
TPD52L2 tumor protein D52-like 2 2.00056

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -6.59411
GOLT1B golgi transport 1B -4.80703
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.74805
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.54777
TUBB6 tubulin, beta 6 class V -4.50621
C1QBP complement component 1, q subcomponent binding protein -3.96312
ERGIC2 ERGIC and golgi 2 -3.62812
GDF15 growth differentiation factor 15 -3.47407
TP53 tumor protein p53 -3.45503
RETREG3 reticulophagy regulator family member 3 -3.41293
TSPAN31 tetraspanin 31 -3.40259
TYROBP TYRO protein tyrosine kinase binding protein -2.9282
EIF3I eukaryotic translation initiation factor 3, subunit I -2.88929
YAF2 YY1 associated factor 2 -2.74218
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -2.69096
RNF11 ring finger protein 11 -2.68231
MEAF6 MYST/Esa1-associated factor 6 -2.64854
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.59807
TRAM1 translocation associated membrane protein 1 -2.57129
ARID4B AT rich interactive domain 4B (RBP1-like) -2.54354
C1QB complement component 1, q subcomponent, B chain -2.5064
HYAL2 hyaluronoglucosaminidase 2 -2.50286
TUBG1 tubulin, gamma 1 -2.49935
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.43017
CPM carboxypeptidase M -2.42879
MRPL18 mitochondrial ribosomal protein L18 -2.3629
MED21 mediator complex subunit 21 -2.35833
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.32992
EMC3 ER membrane protein complex subunit 3 -2.32474
SPX spexin hormone -2.3084
CTSB cathepsin B -2.30417
TMED1 transmembrane emp24 protein transport domain containing 1 -2.29529
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -2.29051
PRPF8 pre-mRNA processing factor 8 -2.29018
DLAT dihydrolipoamide S-acetyltransferase -2.2676
TENT5A terminal nucleotidyltransferase 5A -2.26685
PCCB propionyl CoA carboxylase, beta polypeptide -2.26636
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.24776
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.22518
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.22459
NYNRIN NYN domain and retroviral integrase containing -2.21345
RWDD1 RWD domain containing 1 -2.20323
PURA purine-rich element binding protein A -2.19499
STAMBP STAM binding protein -2.19232
YIPF5 Yip1 domain family, member 5 -2.1862
IFT46 intraflagellar transport 46 -2.18353
RAB11A RAB11A, member RAS oncogene family -2.16714
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -2.15818
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.15574
MRPL49 mitochondrial ribosomal protein L49 -2.15252
ARCN1 archain 1 -2.14999
TBC1D10B TBC1 domain family, member 10B -2.14362
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.14337
GET1 guided entry of tail-anchored proteins factor 1 -2.12979
ELL2 elongation factor, RNA polymerase II, 2 -2.11135
TSPAN3 tetraspanin 3 -2.10605
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.10031
GATAD2A GATA zinc finger domain containing 2A -2.09972
FOXD1 forkhead box D1 -2.08903
TIMP4 TIMP metallopeptidase inhibitor 4 -2.08895
TRIP12 thyroid hormone receptor interactor 12 -2.08802
TMEM135 transmembrane protein 135 -2.08104
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.07857
DRC9 dynein regulatory complex subunit 9 -2.07694
TCIM transcriptional and immune response regulator -2.0587
SEC31A SEC31 homolog A (S. cerevisiae) -2.05339
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.05323
CBR1 carbonyl reductase 1 -2.04863
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.04151
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.03386
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.02905
LIN7A lin-7 homolog A (C. elegans) -2.0263
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.02533
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -2.02114
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.02004
SLC35E1 solute carrier family 35, member E1 -2.01834
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.01425