CRCGN016_MCF10A.WT.HP_24H:B15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.87393
HBA1 hemoglobin, alpha 1 3.53554
ABHD6 abhydrolase domain containing 6 3.52476
PRKCH protein kinase C, eta 3.34738
SMIM40 small integral membrane protein 40 3.02041
MDM4 MDM4, p53 regulator 2.94557
SSBP2 single-stranded DNA binding protein 2 2.86312
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.80713
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.72635
CDC25B cell division cycle 25B 2.54647
THRAP3 thyroid hormone receptor associated protein 3 2.41808
MTA2 metastasis associated 1 family, member 2 2.3292
WFS1 Wolfram syndrome 1 (wolframin) 2.2725
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.2371
NDN necdin, melanoma antigen (MAGE) family member 2.2005
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.14196
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.13767
UBA6 ubiquitin-like modifier activating enzyme 6 2.11691
BCL9 B-cell CLL/lymphoma 9 2.03605
KDM5D lysine (K)-specific demethylase 5D 2.01123
CTBP1 C-terminal binding protein 1 2.01091

decreased expression

Symbol Name Standardized Value
RGS2 regulator of G-protein signaling 2 -3.86042
RPA3 replication protein A3, 14kDa -3.8488
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.70492
PCNA proliferating cell nuclear antigen -3.54199
KRT14 keratin 14, type I -3.36855
BASP1 brain abundant, membrane attached signal protein 1 -3.35389
CDKN2A cyclin-dependent kinase inhibitor 2A -3.33336
HSPA8 heat shock 70kDa protein 8 -3.25217
CHMP4B charged multivesicular body protein 4B -3.2372
DUSP14 dual specificity phosphatase 14 -2.97423
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.76076
COG7 component of oligomeric golgi complex 7 -2.53816
UBE3C ubiquitin protein ligase E3C -2.46704
KDM3A lysine (K)-specific demethylase 3A -2.39417
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.30598
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.13944
DIXDC1 DIX domain containing 1 -2.0177