CRCGN016_MCF10A.WT.HP_24H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methoxy-3-aminodibenzofuran 100.28 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 3.30003
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.26592
WDR7 WD repeat domain 7 3.07967
VAV3 vav 3 guanine nucleotide exchange factor 2.88453
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.61217
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.58262
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.56008
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.46771
TBX2 T-box 2 2.4578
HOXA5 homeobox A5 2.44168
LAGE3 L antigen family, member 3 2.40719
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.26039
CCL2 chemokine (C-C motif) ligand 2 2.25494
TCTN1 tectonic family member 1 2.20907
VEGFB vascular endothelial growth factor B 2.1898
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.18201
GADD45A growth arrest and DNA-damage-inducible, alpha 2.08918
WIF1 WNT inhibitory factor 1 2.03318

decreased expression

Symbol Name Standardized Value
S100A4 S100 calcium binding protein A4 -4.28705
PCCB propionyl CoA carboxylase, beta polypeptide -3.7592
MSMO1 methylsterol monooxygenase 1 -3.4294
RALGDS ral guanine nucleotide dissociation stimulator -3.23299
UBE3C ubiquitin protein ligase E3C -3.15267
RNF167 ring finger protein 167 -3.10061
ALDOC aldolase C, fructose-bisphosphate -3.02993
ADRB2 adrenoceptor beta 2, surface -2.88474
TUBB6 tubulin, beta 6 class V -2.83429
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.73489
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.62589
SH3D19 SH3 domain containing 19 -2.40262
EBNA1BP2 EBNA1 binding protein 2 -2.36681
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.27728
STMN1 stathmin 1 -2.27697
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.10684
TOMM34 translocase of outer mitochondrial membrane 34 -2.06875