CRCGN016_MCF10A.WT.HP_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methoxy-3-aminodibenzofuran 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5D lysine (K)-specific demethylase 5D 4.36375
ACLY ATP citrate lyase 4.05707
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.76503
ZMIZ1 zinc finger, MIZ-type containing 1 3.55705
TBX2 T-box 2 3.459
USP9Y ubiquitin specific peptidase 9, Y-linked 3.33862
TIAM1 T-cell lymphoma invasion and metastasis 1 3.06355
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.93003
HBA1 hemoglobin, alpha 1 2.90183
ACAA1 acetyl-CoA acyltransferase 1 2.82882
ZFY zinc finger protein, Y-linked 2.75095
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.34
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.16115
FGF20 fibroblast growth factor 20 2.1581
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.1523
MACROD1 MACRO domain containing 1 2.13255
LSR lipolysis stimulated lipoprotein receptor 2.03695
CADM1 cell adhesion molecule 1 2.01877
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.0118

decreased expression

Symbol Name Standardized Value
CRK v-crk avian sarcoma virus CT10 oncogene homolog -5.1033
KIF20A kinesin family member 20A -5.04695
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.5559
BASP1 brain abundant, membrane attached signal protein 1 -4.50495
ATF5 activating transcription factor 5 -4.3919
HMG20B high mobility group 20B -4.36458
KRT14 keratin 14, type I -4.11925
CREB1 cAMP responsive element binding protein 1 -4.0852
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.3723
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.29428
ALDOC aldolase C, fructose-bisphosphate -3.17835
PUDP pseudouridine 5'-phosphatase -3.01115
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.97292
UBA1 ubiquitin-like modifier activating enzyme 1 -2.9676
MSN moesin -2.87725
USP9X ubiquitin specific peptidase 9, X-linked -2.8211
SMC1A structural maintenance of chromosomes 1A -2.7728
ZNF430 zinc finger protein 430 -2.5517
KDM6A lysine (K)-specific demethylase 6A -2.44435
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.37385
TUBGCP4 tubulin, gamma complex associated protein 4 -2.37295
TMEM260 transmembrane protein 260 -2.36715
RPS5 ribosomal protein S5 -2.36145
FAIM Fas apoptotic inhibitory molecule -2.26075
NCBP3 nuclear cap binding subunit 3 -2.23305
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.21035
DCTN4 dynactin 4 (p62) -2.1812
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.1729
SEC24A SEC24 family member A -2.1437
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.1387
IPO13 importin 13 -2.13445
DENND4C DENN/MADD domain containing 4C -2.12245
TXNRD1 thioredoxin reductase 1 -2.0806
SLC41A3 solute carrier family 41, member 3 -2.07635
PHACTR4 phosphatase and actin regulator 4 -2.06465
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.06105
RPL26L1 ribosomal protein L26-like 1 -2.02295
RPL11 ribosomal protein L11 -2.01955
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.0143
ATP5F1E ATP synthase F1 subunit epsilon -2.00365
ATP13A1 ATPase type 13A1 -2.0023