CRCGN016_MCF10A.WT.HP_24H:B21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methoxy-3-aminodibenzofuran 11.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MCOLN1 mucolipin 1 5.04143
KCTD5 potassium channel tetramerization domain containing 5 4.89056
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.1186
PPOX protoporphyrinogen oxidase 4.09801
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 3.25265
PNPLA6 patatin-like phospholipase domain containing 6 3.20292
RPP38 ribonuclease P/MRP 38kDa subunit 3.03898
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.81714
RIOX1 ribosomal oxygenase 1 2.74925
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.72591
SYNGAP1 synaptic Ras GTPase activating protein 1 2.72009
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.5237
KEL Kell blood group, metallo-endopeptidase 2.50029
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.49473
FGFR4 fibroblast growth factor receptor 4 2.46427
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.45662
C1QA complement component 1, q subcomponent, A chain 2.42946
RBKS ribokinase 2.32715
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.32252
QTRT1 queuine tRNA-ribosyltransferase 1 2.29709
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 2.28228
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.26023
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.2588
DENND1C DENN/MADD domain containing 1C 2.23891
THAP11 THAP domain containing 11 2.20793
C1QB complement component 1, q subcomponent, B chain 2.20252
DLEC1 deleted in lung and esophageal cancer 1 2.20083
GPR52 G protein-coupled receptor 52 2.18016
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.15822
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.15134
PCDHB12 protocadherin beta 12 2.11673
PADI1 peptidyl arginine deiminase, type I 2.10466
AMHR2 anti-Mullerian hormone receptor, type II 2.0949
CLASRP CLK4-associating serine/arginine rich protein 2.09068
STAB2 stabilin 2 2.08966
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.08459
TSNAXIP1 translin-associated factor X interacting protein 1 2.07611
SLC41A3 solute carrier family 41, member 3 2.07471
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 2.06696
PLIN1 perilipin 1 2.06537
NHLH1 nescient helix loop helix 1 2.06399
CD5L CD5 molecule-like 2.00449

decreased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.41024
PSIP1 PC4 and SFRS1 interacting protein 1 -4.19696
TCEA2 transcription elongation factor A (SII), 2 -3.60808
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.12367
ACAA1 acetyl-CoA acyltransferase 1 -2.85435
HAT1 histone acetyltransferase 1 -2.5801
OGDHL oxoglutarate dehydrogenase-like -2.36557
MSMO1 methylsterol monooxygenase 1 -2.36493
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.34084
FAM169A family with sequence similarity 169, member A -2.31649
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.29394
CAB39 calcium binding protein 39 -2.17387
DENND5A DENN/MADD domain containing 5A -2.13127
HMG20B high mobility group 20B -2.12917
ITM2C integral membrane protein 2C -2.12443
XPO7 exportin 7 -2.11104
BCAS1 breast carcinoma amplified sequence 1 -2.09823
RPA3 replication protein A3, 14kDa -2.09643
TAOK3 TAO kinase 3 -2.08282
MATN2 matrilin 2 -2.0798
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.02696
GSTM3 glutathione S-transferase mu 3 (brain) -2.01839
TALDO1 transaldolase 1 -2.00586
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.00562
RAB17 RAB17, member RAS oncogene family -2.00218