CRCGN016_MCF10A.WT.HP_24H:B23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorambucil 33.19 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

230 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 8.94184
RGS2 regulator of G-protein signaling 2 5.33868
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.08786
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.86061
DDB2 damage-specific DNA binding protein 2, 48kDa 4.56544
CAPN1 calpain 1, (mu/I) large subunit 4.30581
NOTCH1 notch 1 3.92806
STAP2 signal transducing adaptor family member 2 3.83248
TCEA2 transcription elongation factor A (SII), 2 3.68332
ABHD6 abhydrolase domain containing 6 3.54284
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.33504
MVP major vault protein 3.21899
LRP10 low density lipoprotein receptor-related protein 10 3.10931
MINDY1 MINDY lysine 48 deubiquitinase 1 3.10801
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.06331
TUBB6 tubulin, beta 6 class V 2.98657
BAX BCL2-associated X protein 2.89454
FDXR ferredoxin reductase 2.85908
MUC1 mucin 1, cell surface associated 2.75716
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.67844
MXRA5 matrix-remodelling associated 5 2.67436
PIEZO1 piezo-type mechanosensitive ion channel component 1 2.62524
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.61282
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.60388
AGR2 anterior gradient 2 2.5936
NPDC1 neural proliferation, differentiation and control, 1 2.56621
STXBP1 syntaxin binding protein 1 2.52653
SKIC2 SKI2 subunit of superkiller complex 2.51302
ADRB2 adrenoceptor beta 2, surface 2.50558
LSR lipolysis stimulated lipoprotein receptor 2.49647
INPP1 inositol polyphosphate-1-phosphatase 2.47559
AMT aminomethyltransferase 2.47261
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.46621
SPRR3 small proline-rich protein 3 2.46186
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.44507
KRT6A keratin 6A, type II 2.43438
PYCARD PYD and CARD domain containing 2.42883
LGALS9C lectin, galactoside-binding, soluble, 9C 2.42164
TRIM22 tripartite motif containing 22 2.41587
CKMT1A creatine kinase, mitochondrial 1A 2.4054
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.39736
TIGAR TP53 induced glycolysis regulatory phosphatase 2.39386
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.38281
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.38048
ECM1 extracellular matrix protein 1 2.36928
ATP13A2 ATPase type 13A2 2.3562
TP53I3 tumor protein p53 inducible protein 3 2.35413
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.30627
SPRR1B small proline-rich protein 1B 2.30172
ZMAT3 zinc finger, matrin-type 3 2.30023
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.27335
SESN1 sestrin 1 2.26545
MICALL1 MICAL-like 1 2.25782
NBEAL2 neurobeachin-like 2 2.24193
DGKA diacylglycerol kinase, alpha 80kDa 2.24064
IRF6 interferon regulatory factor 6 2.21878
SUGCT succinyl-CoA:glutarate-CoA transferase 2.21753
TPM1 tropomyosin 1 (alpha) 2.21515
KRT34 keratin 34, type I 2.21429
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.21243
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.19671
LINC02762 long intergenic non-protein coding RNA 2762 2.18618
PLA2G15 phospholipase A2, group XV 2.17062
GHR growth hormone receptor 2.16917
TMEM120B transmembrane protein 120B 2.1665
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.16463
GPR87 G protein-coupled receptor 87 2.1601
PDLIM1 PDZ and LIM domain 1 2.15139
CHAF1A chromatin assembly factor 1, subunit A (p150) 2.14655
PTK2B protein tyrosine kinase 2 beta 2.14133
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.13594
RAB17 RAB17, member RAS oncogene family 2.13453
TSPAN1 tetraspanin 1 2.13426
DTX2 deltex 2, E3 ubiquitin ligase 2.1262
CYB5R1 cytochrome b5 reductase 1 2.12254
GMNN geminin, DNA replication inhibitor 2.11314
TM7SF2 transmembrane 7 superfamily member 2 2.10599
EPHA2 EPH receptor A2 2.08938
YIPF1 Yip1 domain family, member 1 2.08602
ARMCX1 armadillo repeat containing, X-linked 1 2.08193
SPRR1A small proline-rich protein 1A 2.08149
CCND3 cyclin D3 2.07588
LOC102724428 serine/threonine-protein kinase SIK1 2.07322
PERP PERP, TP53 apoptosis effector 2.06897
GPC1 glypican 1 2.06667
TICAM1 toll-like receptor adaptor molecule 1 2.05891
TEX2 testis expressed 2 2.04448
FGFBP1 fibroblast growth factor binding protein 1 2.03658
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.03106
RHCG Rh family, C glycoprotein 2.02164
COMP cartilage oligomeric matrix protein 2.01851
SCPEP1 serine carboxypeptidase 1 2.01799
REEP2 receptor accessory protein 2 2.01018
ELMO3 engulfment and cell motility 3 2.00768

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.22595
UBE2C ubiquitin-conjugating enzyme E2C -7.46702
KIF20A kinesin family member 20A -6.86647
PLK1 polo-like kinase 1 -6.49854
PUF60 poly-U binding splicing factor 60KDa -6.04789
KIF14 kinesin family member 14 -5.48905
CCNB2 cyclin B2 -5.48583
PSRC1 proline/serine-rich coiled-coil 1 -5.34428
NCAPD2 non-SMC condensin I complex, subunit D2 -5.01786
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.84043
LBR lamin B receptor -4.54467
TOP2A topoisomerase (DNA) II alpha 170kDa -4.39094
ARID4B AT rich interactive domain 4B (RBP1-like) -4.37527
TOMM34 translocase of outer mitochondrial membrane 34 -4.2917
DEPDC1 DEP domain containing 1 -4.22364
KDM3A lysine (K)-specific demethylase 3A -4.21869
AURKA aurora kinase A -3.97549
CCNB1 cyclin B1 -3.86705
HOXA5 homeobox A5 -3.79582
CENPA centromere protein A -3.73778
CCNA2 cyclin A2 -3.67473
BIRC5 baculoviral IAP repeat containing 5 -3.57716
AURKB aurora kinase B -3.56443
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.43295
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.37094
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.32089
MTERF3 mitochondrial transcription termination factor 3 -3.28919
THAP11 THAP domain containing 11 -3.25043
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -3.15635
CDKN3 cyclin-dependent kinase inhibitor 3 -3.1387
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.07634
DDIT4 DNA-damage-inducible transcript 4 -3.07446
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -3.03616
CDCA8 cell division cycle associated 8 -3.03607
CDCA3 cell division cycle associated 3 -2.99828
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.98163
FBXO5 F-box protein 5 -2.96701
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.96082
ZNF7 zinc finger protein 7 -2.90241
CETN3 centrin, EF-hand protein, 3 -2.88407
PBK PDZ binding kinase -2.87906
XPO7 exportin 7 -2.84579
KIF23 kinesin family member 23 -2.80184
ANAPC10 anaphase promoting complex subunit 10 -2.7966
RPS5 ribosomal protein S5 -2.77648
HJURP Holliday junction recognition protein -2.76751
NEK2 NIMA-related kinase 2 -2.76378
S100A4 S100 calcium binding protein A4 -2.7205
KIF18A kinesin family member 18A -2.70779
SNUPN snurportin 1 -2.66683
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.61782
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.61684
TPX2 TPX2, microtubule-associated -2.6024
PIMREG PICALM interacting mitotic regulator -2.59603
KIF4A kinesin family member 4A -2.57045
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.56052
ZNF146 zinc finger protein 146 -2.54389
CDC25C cell division cycle 25C -2.54285
BRIX1 BRX1, biogenesis of ribosomes -2.53311
PARP1 poly (ADP-ribose) polymerase 1 -2.52982
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.51608
NDC80 NDC80 kinetochore complex component -2.51117
SUMF2 sulfatase modifying factor 2 -2.50036
DNM1 dynamin 1 -2.49792
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.47864
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.45486
EBNA1BP2 EBNA1 binding protein 2 -2.44777
KIF11 kinesin family member 11 -2.43394
SRP72 signal recognition particle 72kDa -2.42599
TRIB3 tribbles pseudokinase 3 -2.42337
TTK TTK protein kinase -2.42097
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.39853
CCNF cyclin F -2.37497
CENPF centromere protein F, 350/400kDa -2.33006
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.32869
HEATR1 HEAT repeat containing 1 -2.32734
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.31915
OIP5 Opa interacting protein 5 -2.31145
DPF2 D4, zinc and double PHD fingers family 2 -2.29119
MKI67 marker of proliferation Ki-67 -2.28442
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.27127
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.27001
SPDL1 spindle apparatus coiled-coil protein 1 -2.26542
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.26263
NRF1 nuclear respiratory factor 1 -2.26037
RACGAP1 Rac GTPase activating protein 1 -2.24352
MED28 mediator complex subunit 28 -2.24283
GIN1 gypsy retrotransposon integrase 1 -2.23307
CDCA4 cell division cycle associated 4 -2.23049
KTN1 kinectin 1 (kinesin receptor) -2.22506
TLCD3A TLC domain containing 3A -2.22098
TSKU tsukushi, small leucine rich proteoglycan -2.21626
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.20869
ZNHIT6 zinc finger, HIT-type containing 6 -2.20816
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.20492
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.20395
MRPL19 mitochondrial ribosomal protein L19 -2.18239
SKA1 spindle and kinetochore associated complex subunit 1 -2.17354
ABT1 activator of basal transcription 1 -2.17119
HILPDA hypoxia inducible lipid droplet-associated -2.16862
COASY CoA synthase -2.16149
SOCS5 suppressor of cytokine signaling 5 -2.15483
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.15143
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.15028
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.13864
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.13088
CYREN cell cycle regulator of NHEJ -2.12794
ZNF16 zinc finger protein 16 -2.12043
CENPN centromere protein N -2.11815
METTL4 methyltransferase like 4 -2.11433
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.11339
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.10988
BOP1 block of proliferation 1 -2.10914
DBF4 DBF4 zinc finger -2.10641
CEP55 centrosomal protein 55kDa -2.10384
ZMYM1 zinc finger, MYM-type 1 -2.08861
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.08734
RBM28 RNA binding motif protein 28 -2.08394
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.08243
MAK16 MAK16 homolog (S. cerevisiae) -2.07559
BORA bora, aurora kinase A activator -2.07457
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.06851
NUSAP1 nucleolar and spindle associated protein 1 -2.0587
TRIM58 tripartite motif containing 58 -2.03893
ERCC6L excision repair cross-complementation group 6-like -2.0366
MTDH metadherin -2.03217
BAG4 BCL2-associated athanogene 4 -2.02997
FBL fibrillarin -2.02218
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -2.02115
KIAA0586 KIAA0586 -2.01706
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.01415
ENOPH1 enolase-phosphatase 1 -2.0139
TMED5 transmembrane emp24 protein transport domain containing 5 -2.00908
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.00573
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.00356
ARHGAP11A Rho GTPase activating protein 11A -2.00085