CRCGN016_MCF10A.WT.HP_24H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorambucil 11.06 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

159 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 7.14488
AGR2 anterior gradient 2 4.98709
ADGRE5 adhesion G protein-coupled receptor E5 4.83847
RGS2 regulator of G-protein signaling 2 4.20292
LRP10 low density lipoprotein receptor-related protein 10 4.01766
STAP2 signal transducing adaptor family member 2 3.80021
DDB2 damage-specific DNA binding protein 2, 48kDa 3.76988
C2CD2 C2 calcium-dependent domain containing 2 3.69394
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.61424
CAPN1 calpain 1, (mu/I) large subunit 3.51016
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.44002
NOTCH1 notch 1 3.31096
AAMDC adipogenesis associated, Mth938 domain containing 3.23773
ZNF586 zinc finger protein 586 3.23103
INPP1 inositol polyphosphate-1-phosphatase 3.21193
MICALL1 MICAL-like 1 3.17438
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.11896
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.11173
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.05673
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.04268
GATA3 GATA binding protein 3 2.86701
RSF1 remodeling and spacing factor 1 2.85033
TICAM1 toll-like receptor adaptor molecule 1 2.82592
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.80185
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.79308
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.77044
MVP major vault protein 2.75446
SESN1 sestrin 1 2.74476
SLC44A4 solute carrier family 44, member 4 2.74004
ELMO3 engulfment and cell motility 3 2.7202
MUC1 mucin 1, cell surface associated 2.70907
TRIM22 tripartite motif containing 22 2.68653
CAPN3 calpain 3, (p94) 2.6097
PHKB phosphorylase kinase, beta 2.58287
SPAG4 sperm associated antigen 4 2.57243
STK10 serine/threonine kinase 10 2.54616
CEMIP2 cell migration inducing hyaluronidase 2 2.53856
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.53222
LSP1 lymphocyte-specific protein 1 2.51849
PYCARD PYD and CARD domain containing 2.5173
RAB38 RAB38, member RAS oncogene family 2.48867
BAX BCL2-associated X protein 2.48426
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.40939
S100A14 S100 calcium binding protein A14 2.40148
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.37554
MAST4 microtubule associated serine/threonine kinase family member 4 2.37128
INPPL1 inositol polyphosphate phosphatase-like 1 2.35355
SQOR sulfide quinone oxidoreductase 2.345
TSPAN1 tetraspanin 1 2.31561
GRN granulin 2.31004
NADSYN1 NAD synthetase 1 2.29541
DDR1 discoidin domain receptor tyrosine kinase 1 2.27996
THAP12 THAP domain containing 12 2.27676
TIGAR TP53 induced glycolysis regulatory phosphatase 2.26275
IGHMBP2 immunoglobulin mu binding protein 2 2.2544
BTG2 BTG family, member 2 2.25115
MX1 MX dynamin-like GTPase 1 2.25042
DUSP14 dual specificity phosphatase 14 2.23597
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.22506
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.2139
PAAF1 proteasomal ATPase-associated factor 1 2.20082
MINDY1 MINDY lysine 48 deubiquitinase 1 2.18778
SYTL2 synaptotagmin-like 2 2.16492
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.16035
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.15799
ZNF671 zinc finger protein 671 2.15015
REPS2 RALBP1 associated Eps domain containing 2 2.13437
HHAT hedgehog acyltransferase 2.11919
TCEAL4 transcription elongation factor A (SII)-like 4 2.10909
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.10365
STXBP1 syntaxin binding protein 1 2.09644
CEL carboxyl ester lipase 2.09307
UVRAG UV radiation resistance associated 2.05768
GJB5 gap junction protein, beta 5, 31.1kDa 2.05304
FHL2 four and a half LIM domains 2 2.0523
FXYD3 FXYD domain containing ion transport regulator 3 2.04522
CDK7 cyclin-dependent kinase 7 2.02834
NISCH nischarin 2.02615
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.02358
MSRB1 methionine sulfoxide reductase B1 2.01747
RPP38 ribonuclease P/MRP 38kDa subunit 2.01017
RTP4 receptor (chemosensory) transporter protein 4 2.00573

decreased expression

Symbol Name Standardized Value
PSRC1 proline/serine-rich coiled-coil 1 -5.10237
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.82041
NCAPD2 non-SMC condensin I complex, subunit D2 -4.40083
CCNB1 cyclin B1 -4.23331
RPA3 replication protein A3, 14kDa -4.18859
CDC20 cell division cycle 20 -4.12981
PLK1 polo-like kinase 1 -3.80532
UBE2C ubiquitin-conjugating enzyme E2C -3.73067
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.6435
TOMM34 translocase of outer mitochondrial membrane 34 -3.56677
CHIC2 cysteine-rich hydrophobic domain 2 -3.56233
CCNB2 cyclin B2 -3.498
IGFBP1 insulin-like growth factor binding protein 1 -3.28865
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.13351
THAP11 THAP domain containing 11 -3.06097
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.9827
KIF14 kinesin family member 14 -2.95974
LBR lamin B receptor -2.91254
VDAC1 voltage-dependent anion channel 1 -2.88713
FBXO5 F-box protein 5 -2.73317
MRGBP MRG/MORF4L binding protein -2.66162
KIF20A kinesin family member 20A -2.63644
OSGIN2 oxidative stress induced growth inhibitor family member 2 -2.59254
TIMP1 TIMP metallopeptidase inhibitor 1 -2.5253
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.52037
DNM1 dynamin 1 -2.50908
BCCIP BRCA2 and CDKN1A interacting protein -2.50656
PUS7 pseudouridylate synthase 7 (putative) -2.50105
BRIX1 BRX1, biogenesis of ribosomes -2.4807
SCRG1 stimulator of chondrogenesis 1 -2.41212
SAP30 Sin3A-associated protein, 30kDa -2.40097
MT1X metallothionein 1X -2.3982
C1QBP complement component 1, q subcomponent binding protein -2.39193
CENPA centromere protein A -2.38674
KDM3A lysine (K)-specific demethylase 3A -2.38636
RPIA ribose 5-phosphate isomerase A -2.36489
TTYH1 tweety family member 1 -2.36237
BIRC5 baculoviral IAP repeat containing 5 -2.36192
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.3458
CDO1 cysteine dioxygenase type 1 -2.30974
S100A8 S100 calcium binding protein A8 -2.30597
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -2.28746
EGR1 early growth response 1 -2.26876
ATG3 autophagy related 3 -2.26594
KIF11 kinesin family member 11 -2.26445
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.25389
DEPDC1 DEP domain containing 1 -2.25006
WASF1 WAS protein family, member 1 -2.24823
RRAGA Ras-related GTP binding A -2.24713
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.23216
CDCA3 cell division cycle associated 3 -2.20621
ARHGAP11A Rho GTPase activating protein 11A -2.20357
CEP170 centrosomal protein 170kDa -2.1932
HMGB2 high mobility group box 2 -2.18668
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.18373
ACAA1 acetyl-CoA acyltransferase 1 -2.16571
HHEX hematopoietically expressed homeobox -2.16355
ZFHX4 zinc finger homeobox 4 -2.16281
FAIM Fas apoptotic inhibitory molecule -2.15985
PHF10 PHD finger protein 10 -2.14951
RBM12B RNA binding motif protein 12B -2.1372
C1QB complement component 1, q subcomponent, B chain -2.13346
DNAAF2 dynein, axonemal, assembly factor 2 -2.13091
DDIT4 DNA-damage-inducible transcript 4 -2.09494
RHOBTB3 Rho-related BTB domain containing 3 -2.09143
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.09094
BYSL bystin-like -2.08036
MARCHF5 membrane associated ring-CH-type finger 5 -2.07037
EBNA1BP2 EBNA1 binding protein 2 -2.06695
RSBN1 round spermatid basic protein 1 -2.05995
TWNK twinkle mtDNA helicase -2.04506
ASXL1 additional sex combs like transcriptional regulator 1 -2.02616
CDKN3 cyclin-dependent kinase inhibitor 3 -2.02105
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.01441
TCERG1 transcription elongation regulator 1 -2.01387
INHBB inhibin, beta B -2.01257
CUTC cutC copper transporter -2.00429