CRCGN016_MCF10A.WT.HP_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indirubin 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.5945
HMOX1 heme oxygenase 1 3.62868
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.55653
IL1B interleukin 1, beta 2.82234
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.69271
HBB hemoglobin, beta 2.67085
CHN1 chimerin 1 2.66943
CRELD2 cysteine-rich with EGF-like domains 2 2.57059
TXNRD1 thioredoxin reductase 1 2.47607
GADD45A growth arrest and DNA-damage-inducible, alpha 2.44581
SATB1 SATB homeobox 1 2.43041
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.414
H2BC21 H2B clustered histone 21 2.30224
SMIM40 small integral membrane protein 40 2.02113

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -4.56198
JMJD6 jumonji domain containing 6 -4.03764
PCCB propionyl CoA carboxylase, beta polypeptide -3.95115
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.92911
CD81 CD81 molecule -3.65774
MXRA7 matrix-remodelling associated 7 -3.24488
TES testin LIM domain protein -3.19312
TP53 tumor protein p53 -2.58894
TYROBP TYRO protein tyrosine kinase binding protein -2.16054
SYNGR3 synaptogyrin 3 -2.10525
RALGDS ral guanine nucleotide dissociation stimulator -2.08514
KDM3A lysine (K)-specific demethylase 3A -2.05373
ARID4B AT rich interactive domain 4B (RBP1-like) -2.0173