CRCGN016_MCF10A.WT.HP_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cw-051 perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

259 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.17596
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 8.36399
CTSL cathepsin L 7.78189
TXNRD1 thioredoxin reductase 1 7.55572
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 7.18718
STX1A syntaxin 1A (brain) 6.60029
EPHB2 EPH receptor B2 6.542
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 6.43615
ABHD6 abhydrolase domain containing 6 5.84232
GLRX glutaredoxin (thioltransferase) 5.71219
UGDH UDP-glucose 6-dehydrogenase 5.51942
TRIB3 tribbles pseudokinase 3 5.32615
FHL2 four and a half LIM domains 2 5.02322
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.96021
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.93195
GFPT1 glutamine--fructose-6-phosphate transaminase 1 4.6593
GARS1 glycyl-tRNA synthetase 1 4.63365
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.61303
PHGDH phosphoglycerate dehydrogenase 4.60242
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 4.59876
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 4.49299
AARS1 alanyl-tRNA synthetase 1 4.47871
SQSTM1 sequestosome 1 4.27297
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.24344
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.99227
PSAT1 phosphoserine aminotransferase 1 3.98988
GCLM glutamate-cysteine ligase, modifier subunit 3.95282
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3.85829
LRP10 low density lipoprotein receptor-related protein 10 3.82013
OLFML2B olfactomedin-like 2B 3.78074
NUCB2 nucleobindin 2 3.59473
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 3.571
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.54867
C2CD2 C2 calcium-dependent domain containing 2 3.51408
CARS1 cysteinyl-tRNA synthetase 1 3.49024
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.47761
EGR1 early growth response 1 3.47491
TGFBI transforming growth factor, beta-induced, 68kDa 3.46006
AGR2 anterior gradient 2 3.45924
CHIC2 cysteine-rich hydrophobic domain 2 3.45531
GRB10 growth factor receptor-bound protein 10 3.38287
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.35222
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 3.31032
ABHD4 abhydrolase domain containing 4 3.20499
NRIP1 nuclear receptor interacting protein 1 3.18591
MAP7 microtubule-associated protein 7 3.12142
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 3.11932
LIF leukemia inhibitory factor 3.05856
VRK2 vaccinia related kinase 2 3.02496
LOC128125814 uncharacterized LOC128125814 3.02492
YARS1 tyrosyl-tRNA synthetase 1 3.01105
TRIB1 tribbles pseudokinase 1 2.99279
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.94304
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.8984
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.84599
SMAD3 SMAD family member 3 2.82028
PPARG peroxisome proliferator-activated receptor gamma 2.7919
TARS1 threonyl-tRNA synthetase 1 2.78096
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.72606
FN1 fibronectin 1 2.72479
FLNB filamin B, beta 2.67136
PYCR1 pyrroline-5-carboxylate reductase 1 2.65456
POPDC3 popeye domain containing 3 2.63952
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.6233
IER3 immediate early response 3 2.61743
IL1B interleukin 1, beta 2.61127
FOSL1 FOS-like antigen 1 2.60393
AKR1C3 aldo-keto reductase family 1, member C3 2.60198
PRSS2 protease, serine, 2 (trypsin 2) 2.56832
LARP6 La ribonucleoprotein domain family, member 6 2.55879
HBEGF heparin-binding EGF-like growth factor 2.55442
HMGA2 high mobility group AT-hook 2 2.5454
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.5352
CDCP1 CUB domain containing protein 1 2.53158
SLC67A1 solute carrier family 67 member 1 2.53133
SYNGAP1 synaptic Ras GTPase activating protein 1 2.50749
TBX2 T-box 2 2.50364
COMP cartilage oligomeric matrix protein 2.48992
STC2 stanniocalcin 2 2.4887
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.46888
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.43714
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.40295
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.40034
EGR3 early growth response 3 2.37164
FHOD1 formin homology 2 domain containing 1 2.36068
CADM1 cell adhesion molecule 1 2.35845
NCK2 NCK adaptor protein 2 2.34342
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.33223
ATF4 activating transcription factor 4 2.32647
SLC16A6 solute carrier family 16, member 6 2.32533
S100P S100 calcium binding protein P 2.32504
SQOR sulfide quinone oxidoreductase 2.31329
PRSS3 protease, serine, 3 2.29999
NARS1 asparaginyl-tRNA synthetase 1 2.29448
COL6A3 collagen, type VI, alpha 3 2.29339
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.2906
GPC1 glypican 1 2.2852
TBCA tubulin folding cofactor A 2.27236
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.25196
INPP1 inositol polyphosphate-1-phosphatase 2.25133
SARS1 seryl-tRNA synthetase 1 2.24145
G0S2 G0/G1 switch 2 2.23213
DUSP6 dual specificity phosphatase 6 2.21789
IGFBP4 insulin-like growth factor binding protein 4 2.21466
GPX2 glutathione peroxidase 2 2.20643
XPOT exportin, tRNA 2.20438
MCUR1 mitochondrial calcium uniporter regulator 1 2.19592
UNC5B unc-5 homolog B (C. elegans) 2.17894
CNMD chondromodulin 2.17629
ADGRG2 adhesion G protein-coupled receptor G2 2.17492
IGHMBP2 immunoglobulin mu binding protein 2 2.17294
SH2B3 SH2B adaptor protein 3 2.17256
VAT1 vesicle amine transport 1 2.17012
MARS1 methionyl-tRNA synthetase 1 2.16565
PLEC plectin 2.15819
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.14687
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.12558
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 2.1235
DDR2 discoidin domain receptor tyrosine kinase 2 2.12141
VEGFC vascular endothelial growth factor C 2.1207
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.10369
STAMBP STAM binding protein 2.09674
HDLBP high density lipoprotein binding protein 2.08285
TPSG1 tryptase gamma 1 2.08027
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.07496
CALML5 calmodulin-like 5 2.07039
JAK1 Janus kinase 1 2.06405
DVL3 dishevelled segment polarity protein 3 2.05551
HBA1 hemoglobin, alpha 1 2.05202
RHOF ras homolog family member F (in filopodia) 2.05035
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.04539
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.03997
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.03759
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.03588
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.03064
TALDO1 transaldolase 1 2.02321
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.02122
CALU calumenin 2.01367
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.00255

decreased expression

Symbol Name Standardized Value
PPIC peptidylprolyl isomerase C (cyclophilin C) -5.86673
ADRB2 adrenoceptor beta 2, surface -4.91747
NUP85 nucleoporin 85kDa -4.55219
RNF167 ring finger protein 167 -4.51577
S100A4 S100 calcium binding protein A4 -4.42082
S100A8 S100 calcium binding protein A8 -3.6477
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.56646
EXOSC4 exosome component 4 -3.46625
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.40951
ARID4B AT rich interactive domain 4B (RBP1-like) -3.21567
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.1664
NOTCH1 notch 1 -3.13737
STMN1 stathmin 1 -3.13434
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -3.08031
TSC22D3 TSC22 domain family, member 3 -3.06486
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.04776
CPM carboxypeptidase M -2.9298
ADI1 acireductone dioxygenase 1 -2.86677
DCK deoxycytidine kinase -2.84474
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.82703
ZNF813 zinc finger protein 813 -2.81194
UFM1 ubiquitin-fold modifier 1 -2.8019
KCTD2 potassium channel tetramerization domain containing 2 -2.77645
SESN1 sestrin 1 -2.76805
TDRD12 tudor domain containing 12 -2.72679
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.69888
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.68778
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.64616
NCAPD2 non-SMC condensin I complex, subunit D2 -2.64473
TRAP1 TNF receptor-associated protein 1 -2.63689
RFC3 replication factor C (activator 1) 3, 38kDa -2.62358
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.61315
RALGDS ral guanine nucleotide dissociation stimulator -2.57763
MVD mevalonate (diphospho) decarboxylase -2.57261
GMNN geminin, DNA replication inhibitor -2.55408
FEN1 flap structure-specific endonuclease 1 -2.54882
RPA3 replication protein A3, 14kDa -2.54018
JADE2 jade family PHD finger 2 -2.53404
MRPS7 mitochondrial ribosomal protein S7 -2.52471
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.52286
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -2.5163
ZBTB16 zinc finger and BTB domain containing 16 -2.50547
MSMO1 methylsterol monooxygenase 1 -2.5047
MTNAP1 mitochondrial nucleoid associated protein 1 -2.50442
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.48626
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.48477
SPIN2B spindlin family, member 2B -2.41704
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.41294
ESRP2 epithelial splicing regulatory protein 2 -2.38777
GPR6 G protein-coupled receptor 6 -2.36166
RTL10 retrotransposon Gag like 10 -2.36153
CAPN1 calpain 1, (mu/I) large subunit -2.35313
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.34811
ALDOC aldolase C, fructose-bisphosphate -2.3394
TMC5 transmembrane channel-like 5 -2.31752
MICA MHC class I polypeptide-related sequence A -2.31673
CCDC47 coiled-coil domain containing 47 -2.31527
FAIM Fas apoptotic inhibitory molecule -2.29622
GPS1 G protein pathway suppressor 1 -2.29608
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.27837
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -2.26446
KRT24 keratin 24, type I -2.26235
MUC1 mucin 1, cell surface associated -2.26234
LPL lipoprotein lipase -2.23758
MAP9 microtubule-associated protein 9 -2.22473
ANXA11 annexin A11 -2.22029
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -2.21051
DPYD dihydropyrimidine dehydrogenase -2.20269
KAT8 K(lysine) acetyltransferase 8 -2.20038
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.19995
ITGB8 integrin, beta 8 -2.19994
NME5 NME/NM23 family member 5 -2.19401
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.19079
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.19051
ZNF629 zinc finger protein 629 -2.19039
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.18988
MRPL12 mitochondrial ribosomal protein L12 -2.1842
CDK1 cyclin-dependent kinase 1 -2.18203
RGS2 regulator of G-protein signaling 2 -2.17418
GTPBP8 GTP-binding protein 8 (putative) -2.17291
VEGFB vascular endothelial growth factor B -2.1708
ADGRL3 adhesion G protein-coupled receptor L3 -2.16896
MRPL49 mitochondrial ribosomal protein L49 -2.16497
ERI2 ERI1 exoribonuclease family member 2 -2.16303
TFCP2L1 transcription factor CP2-like 1 -2.15776
PHOX2B paired-like homeobox 2b -2.14938
FKBP5 FK506 binding protein 5 -2.14882
ARMC7 armadillo repeat containing 7 -2.14503
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.13443
PALMD palmdelphin -2.13286
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.13169
DPH2 DPH2 homolog (S. cerevisiae) -2.12246
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.09552
NFIB nuclear factor I/B -2.0932
BIRC5 baculoviral IAP repeat containing 5 -2.09227
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.08789
UBE2C ubiquitin-conjugating enzyme E2C -2.08731
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.08544
MED21 mediator complex subunit 21 -2.08505
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.08287
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -2.08007
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.06745
ZCCHC10 zinc finger, CCHC domain containing 10 -2.06482
NUP107 nucleoporin 107kDa -2.06031
NFIL3 nuclear factor, interleukin 3 regulated -2.05375
CXXC4 CXXC finger protein 4 -2.05302
NIPSNAP2 nipsnap homolog 2 -2.05298
FOXO1 forkhead box O1 -2.05122
VAV3 vav 3 guanine nucleotide exchange factor -2.0491
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.03435
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.03188
TTYH1 tweety family member 1 -2.02666
MYNN myoneurin -2.02601
MAB21L1 mab-21-like 1 (C. elegans) -2.01815
DMD dystrophin -2.01773
CRIPT cysteine-rich PDZ-binding protein -2.0168
ING4 inhibitor of growth family, member 4 -2.01448
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.01366
TMLHE trimethyllysine hydroxylase, epsilon -2.00723
TRIM22 tripartite motif containing 22 -2.00298