CRCGN016_MCF10A.WT.HP_24H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pcb126 with tbt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 4.69475
APOE apolipoprotein E 4.50673
INTS3 integrator complex subunit 3 4.30385
PPOX protoporphyrinogen oxidase 4.25575
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.7629
PTK2 protein tyrosine kinase 2 3.6352
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.43475
TCEA2 transcription elongation factor A (SII), 2 3.40465
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 3.1852
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.90025
HBZ hemoglobin, zeta 2.88795
CLXN calaxin 2.80215
CFAP45 cilia and flagella associated protein 45 2.7643
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.6665
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.51635
ACAA1 acetyl-CoA acyltransferase 1 2.5155
SCT secretin 2.48445
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.47415
ACHE acetylcholinesterase (Yt blood group) 2.4007
PPT2 palmitoyl-protein thioesterase 2 2.3855
KEL Kell blood group, metallo-endopeptidase 2.37195
ZBBX zinc finger, B-box domain containing 2.35875
SPTA1 spectrin, alpha, erythrocytic 1 2.338
NANOS2 nanos homolog 2 (Drosophila) 2.33065
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.33065
KLF1 Kruppel-like factor 1 (erythroid) 2.31515
ADGRB1 adhesion G protein-coupled receptor B1 2.30335
CHD9NB CHD9 neighbor 2.30025
WDR46 WD repeat domain 46 2.29275
SRPK3 SRSF protein kinase 3 2.29115
ZFPM2 zinc finger protein, FOG family member 2 2.2794
TUBA4B tubulin, alpha 4b 2.26975
MYOG myogenin (myogenic factor 4) 2.25765
ANKRD34C ankyrin repeat domain 34C 2.2522
NGF nerve growth factor (beta polypeptide) 2.23585
PITX2 paired-like homeodomain 2 2.2313
CADM1 cell adhesion molecule 1 2.2272
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.21975
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 2.21485
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.19935
NUP107 nucleoporin 107kDa 2.19625
TMEM74B transmembrane protein 74B 2.19405
ZNF324B zinc finger protein 324B 2.1805
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.17325
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.1655
HGH1 HGH1 homolog (S. cerevisiae) 2.12858
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.1241
NUP153 nucleoporin 153kDa 2.12395
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.12275
GATA6 GATA binding protein 6 2.1137
NCK1 NCK adaptor protein 1 2.09655
GPR39 G protein-coupled receptor 39 2.068
PITX3 paired-like homeodomain 3 2.06135
ECEL1 endothelin converting enzyme-like 1 2.0606
FSHR follicle stimulating hormone receptor 2.0513
MYF6 myogenic factor 6 (herculin) 2.0472
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.0463
RHD Rh blood group, D antigen 2.04475
ATP13A1 ATPase type 13A1 2.04105
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.0339
PBOV1 prostate and breast cancer overexpressed 1 2.02985
XPA xeroderma pigmentosum, complementation group A 2.02445
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.0244
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.0235
GRIP2 glutamate receptor interacting protein 2 2.01745
DNAI2 dynein, axonemal, intermediate chain 2 2.0141

decreased expression

Symbol Name Standardized Value
CLIC4 chloride intracellular channel 4 -5.8543
KRT14 keratin 14, type I -5.40795
KIF14 kinesin family member 14 -5.32125
UFM1 ubiquitin-fold modifier 1 -5.19235
HMG20B high mobility group 20B -5.1439
CRK v-crk avian sarcoma virus CT10 oncogene homolog -5.07967
BAG3 BCL2-associated athanogene 3 -4.7953
PCNA proliferating cell nuclear antigen -4.66275
S100A8 S100 calcium binding protein A8 -4.50225
DCK deoxycytidine kinase -3.31485
CREG1 cellular repressor of E1A-stimulated genes 1 -3.28245
MT1X metallothionein 1X -3.10048
C1QBP complement component 1, q subcomponent binding protein -3.06555
TIMP1 TIMP metallopeptidase inhibitor 1 -2.96335
DENND4C DENN/MADD domain containing 4C -2.93885
PFN1 profilin 1 -2.8804
FOXC1 forkhead box C1 -2.75685
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.6864
S100A4 S100 calcium binding protein A4 -2.6819
GRAMD4 GRAM domain containing 4 -2.6067
FOXJ3 forkhead box J3 -2.5106
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.49345
MKKS McKusick-Kaufman syndrome -2.39805
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.3944
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.3756
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.3734
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.36655
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -2.2578
PTOV1 prostate tumor overexpressed 1 -2.24425
GK glycerol kinase -2.23354
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -2.2084
TMEM230 transmembrane protein 230 -2.1768
SNX24 sorting nexin 24 -2.14475
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -2.1389
AFTPH aftiphilin -2.11935
FNDC3A fibronectin type III domain containing 3A -2.0858
RGS2 regulator of G-protein signaling 2 -2.0846
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.07117
EXOC5 exocyst complex component 5 -2.0376
CREB5 cAMP responsive element binding protein 5 -2.0263