CRCGN016_MCF10A.WT.HP_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pcb126 with tbt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

142 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 10.0
E2F2 E2F transcription factor 2 5.10655
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.8261
MAMLD1 mastermind-like domain containing 1 4.6261
USP6NL USP6 N-terminal like 4.5034
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.45542
ADRB2 adrenoceptor beta 2, surface 3.8887
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.55355
MFF mitochondrial fission factor 3.54425
MTM1 myotubularin 1 2.9385
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.9143
BHLHE41 basic helix-loop-helix family, member e41 2.83535
DMAP1 DNA methyltransferase 1 associated protein 1 2.82875
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.74495
TCEA2 transcription elongation factor A (SII), 2 2.7389
SOX5 SRY (sex determining region Y)-box 5 2.73705
E2F5 E2F transcription factor 5, p130-binding 2.6741
PHKB phosphorylase kinase, beta 2.66027
DOK5 docking protein 5 2.5627
EYA2 EYA transcriptional coactivator and phosphatase 2 2.4997
LHX2 LIM homeobox 2 2.49747
EGLN1 egl-9 family hypoxia-inducible factor 1 2.48565
SLC6A16 solute carrier family 6, member 16 2.4651
USP2 ubiquitin specific peptidase 2 2.4494
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.44605
KAT6B K(lysine) acetyltransferase 6B 2.44084
NGLY1 N-glycanase 1 2.40625
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.40613
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.40417
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.389
BACE2 beta-site APP-cleaving enzyme 2 2.35965
ODF2 outer dense fiber of sperm tails 2 2.3525
AKAP3 A kinase (PRKA) anchor protein 3 2.28805
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.27015
TRIP10 thyroid hormone receptor interactor 10 2.2688
TENT5C terminal nucleotidyltransferase 5C 2.26015
RPP38 ribonuclease P/MRP 38kDa subunit 2.25825
SNTG1 syntrophin, gamma 1 2.25235
ZMYM3 zinc finger, MYM-type 3 2.24795
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.21815
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.20965
METTL2A methyltransferase like 2A 2.19875
RAB28 RAB28, member RAS oncogene family 2.1889
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.18745
CCNH cyclin H 2.1812
KNTC1 kinetochore associated 1 2.1773
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.1751
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 2.16385
ACAA1 acetyl-CoA acyltransferase 1 2.16073
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.15535
CDK14 cyclin-dependent kinase 14 2.15228
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.14495
ZNF667 zinc finger protein 667 2.1339
TMLHE trimethyllysine hydroxylase, epsilon 2.12795
ZNF493 zinc finger protein 493 2.1158
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.11485
MROH7 maestro heat-like repeat family member 7 2.11275
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.09713
MCTP2 multiple C2 domains, transmembrane 2 2.0846
PDZRN4 PDZ domain containing ring finger 4 2.0799
MTERF4 mitochondrial transcription termination factor 4 2.07615
PRR5L proline rich 5 like 2.06935
PYY peptide YY 2.0689
IQCB1 IQ motif containing B1 2.0688
DKKL1 dickkopf-like 1 2.06785
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.06385
TMEM120B transmembrane protein 120B 2.0627
TMEM74B transmembrane protein 74B 2.06105
RPGRIP1L RPGRIP1-like 2.05835
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.0569
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.04745
ZBBX zinc finger, B-box domain containing 2.04525
SPTA1 spectrin, alpha, erythrocytic 1 2.03835
IL12A interleukin 12A 2.02095
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.01393
PIBF1 progesterone immunomodulatory binding factor 1 2.01225
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.01165
ELP4 elongator acetyltransferase complex subunit 4 2.00975
CCDC88C coiled-coil domain containing 88C 2.0025

decreased expression

Symbol Name Standardized Value
CDC25B cell division cycle 25B -5.33725
TLCD3A TLC domain containing 3A -5.25305
C2CD5 C2 calcium-dependent domain containing 5 -4.97105
TXNDC9 thioredoxin domain containing 9 -4.71648
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.62275
YME1L1 YME1-like 1 ATPase -4.57902
GDF15 growth differentiation factor 15 -4.3837
CCNB1 cyclin B1 -4.07015
CBR3 carbonyl reductase 3 -3.87165
TIMP1 TIMP metallopeptidase inhibitor 1 -3.4542
SORBS3 sorbin and SH3 domain containing 3 -3.36392
LGALS7B lectin, galactoside-binding, soluble, 7B -3.296
ARID4B AT rich interactive domain 4B (RBP1-like) -3.23095
REEP5 receptor accessory protein 5 -3.22005
SDF2 stromal cell-derived factor 2 -3.02075
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.89863
RAB15 RAB15, member RAS oncogene family -2.70595
COX6C cytochrome c oxidase subunit VIc -2.6927
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.67613
MZT2B mitotic spindle organizing protein 2B -2.65495
TACC2 transforming, acidic coiled-coil containing protein 2 -2.64
KRT1 keratin 1, type II -2.53045
DUSP14 dual specificity phosphatase 14 -2.48655
WAC WW domain containing adaptor with coiled-coil -2.46945
ABI1 abl-interactor 1 -2.46237
MZT2A mitotic spindle organizing protein 2A -2.4519
DSTN destrin (actin depolymerizing factor) -2.44275
CXCL14 chemokine (C-X-C motif) ligand 14 -2.4417
SMAGP small cell adhesion glycoprotein -2.4248
TCF7 transcription factor 7 (T-cell specific, HMG-box) -2.41123
HSPA2 heat shock 70kDa protein 2 -2.3531
KRT75 keratin 75, type II -2.34315
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.3273
GSTA4 glutathione S-transferase alpha 4 -2.32455
DSG1 desmoglein 1 -2.31285
PDCL3 phosducin-like 3 -2.30105
MRPL23 mitochondrial ribosomal protein L23 -2.2817
ARHGAP12 Rho GTPase activating protein 12 -2.2725
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.26635
RPL36 ribosomal protein L36 -2.2447
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -2.20465
COXFA4 cytochrome c oxidase associated subunit FA4 -2.17765
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.17208
COPZ2 coatomer protein complex, subunit zeta 2 -2.15055
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -2.14565
CD3D CD3d molecule, delta (CD3-TCR complex) -2.13935
TAOK1 TAO kinase 1 -2.12385
HAUS2 HAUS augmin-like complex, subunit 2 -2.10395
FAM174C family with sequence similarity 174 member C -2.0986
DMBT1 deleted in malignant brain tumors 1 -2.09575
MMP3 matrix metallopeptidase 3 -2.0934
BPIFA1 BPI fold containing family A, member 1 -2.0933
CD207 CD207 molecule, langerin -2.0765
TMEM131 transmembrane protein 131 -2.0609
ZNF638 zinc finger protein 638 -2.05155
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.05095
RPS27L ribosomal protein S27-like -2.0479
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.03835
HSPA1A heat shock 70kDa protein 1A -2.0341
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.03285
PCOLCE procollagen C-endopeptidase enhancer -2.0186
ZDHHC18 zinc finger, DHHC-type containing 18 -2.01425
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.01075