CRCGN016_MCF10A.WT.HP_24H:C12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pcb126 with tbt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.56013
ADAM10 ADAM metallopeptidase domain 10 5.33549
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.19984
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.98799
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.91039
LSR lipolysis stimulated lipoprotein receptor 2.89181
CRELD2 cysteine-rich with EGF-like domains 2 2.83513
EPHB2 EPH receptor B2 2.80403
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.80001
SQOR sulfide quinone oxidoreductase 2.67323
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.62435
COMP cartilage oligomeric matrix protein 2.5967
AGPS alkylglycerone phosphate synthase 2.51359
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.42384
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.37681
MUC4 mucin 4, cell surface associated 2.35517
BCCIP BRCA2 and CDKN1A interacting protein 2.29852
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.17593
OLFML2B olfactomedin-like 2B 2.10006
TXNL4B thioredoxin-like 4B 2.08398
TMEM147 transmembrane protein 147 2.02979

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.9628
TUBB6 tubulin, beta 6 class V -4.53058
PMM2 phosphomannomutase 2 -4.26839
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.14345
HSPA8 heat shock 70kDa protein 8 -3.12989
YME1L1 YME1-like 1 ATPase -3.10254
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.88603
TIMP1 TIMP metallopeptidase inhibitor 1 -2.8211
LAP3 leucine aminopeptidase 3 -2.74936
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.53582
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.46521
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.41417
TERF2IP telomeric repeat binding factor 2, interacting protein -2.37473
VDAC1 voltage-dependent anion channel 1 -2.28016
CCNB2 cyclin B2 -2.25974
ZNF430 zinc finger protein 430 -2.15403
DYNLT3 dynein, light chain, Tctex-type 3 -2.1438
CCNB1 cyclin B1 -2.11355
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -2.04651
CD320 CD320 molecule -2.02282
ANXA2 annexin A2 -2.02205
IL2RB interleukin 2 receptor, beta -2.00306