CRCGN016_MCF10A.WT.HP_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 102.48 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
OXSR1 oxidative stress responsive 1 4.68402
TICAM1 toll-like receptor adaptor molecule 1 4.55555
COMP cartilage oligomeric matrix protein 4.5373
WIF1 WNT inhibitory factor 1 3.80701
CNPY3 canopy FGF signaling regulator 3 3.80206
ZNF586 zinc finger protein 586 3.52471
VAV3 vav 3 guanine nucleotide exchange factor 3.39764
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.15431
TBX2 T-box 2 3.07524
AGR2 anterior gradient 2 2.99973
CCL2 chemokine (C-C motif) ligand 2 2.95117
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.83407
ARID5B AT rich interactive domain 5B (MRF1-like) 2.67079
RAI14 retinoic acid induced 14 2.4867
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.47675
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.45691
RPP38 ribonuclease P/MRP 38kDa subunit 2.44155
NRBF2 nuclear receptor binding factor 2 2.3567
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.34858
SPRY2 sprouty homolog 2 (Drosophila) 2.28203
CARM1 coactivator-associated arginine methyltransferase 1 2.18498
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.14792
HMGA2 high mobility group AT-hook 2 2.0433
CCL7 chemokine (C-C motif) ligand 7 2.03163
PCDHB11 protocadherin beta 11 2.03152
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.01811
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.011

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.0008
S100A8 S100 calcium binding protein A8 -5.42932
HOXA5 homeobox A5 -4.05372
ALDOC aldolase C, fructose-bisphosphate -4.03498
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.16985
NUSAP1 nucleolar and spindle associated protein 1 -3.07249
XPO7 exportin 7 -2.91926
CREB1 cAMP responsive element binding protein 1 -2.81573
BASP1 brain abundant, membrane attached signal protein 1 -2.73077
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.70231
OAZ2 ornithine decarboxylase antizyme 2 -2.6178
PARP2 poly (ADP-ribose) polymerase 2 -2.53495
INSIG1 insulin induced gene 1 -2.5094
ATG3 autophagy related 3 -2.48516
UBE3C ubiquitin protein ligase E3C -2.43782
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.29751
FADS2 fatty acid desaturase 2 -2.28027
ANXA2 annexin A2 -2.26206
CLCA2 chloride channel accessory 2 -2.18989
PHF21A PHD finger protein 21A -2.15838
CCNB2 cyclin B2 -2.15096
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.14354
COPS7A COP9 signalosome subunit 7A -2.05198
ARID4B AT rich interactive domain 4B (RBP1-like) -2.04686
CARTPT CART prepropeptide -2.0288
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.02749
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.00478