CRCGN016_MCF10A.WT.HP_24H:C14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 34.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.71605
EVL Enah/Vasp-like 3.22404
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.98143
AGR2 anterior gradient 2 2.95725
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.89895
STAP2 signal transducing adaptor family member 2 2.46838
HBA1 hemoglobin, alpha 1 2.42676
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.40716
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.36919
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.10065
SATB1 SATB homeobox 1 2.09963
SYNGAP1 synaptic Ras GTPase activating protein 1 2.09614

decreased expression

Symbol Name Standardized Value
COPS7A COP9 signalosome subunit 7A -4.08774
OXA1L oxidase (cytochrome c) assembly 1-like -3.78792
MSMO1 methylsterol monooxygenase 1 -3.76964
HMG20B high mobility group 20B -3.71127
KIF14 kinesin family member 14 -3.55035
KRT14 keratin 14, type I -3.37191
VDAC1 voltage-dependent anion channel 1 -3.21658
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.05975
ARID4B AT rich interactive domain 4B (RBP1-like) -2.98792
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.90832
MTERF3 mitochondrial transcription termination factor 3 -2.44609
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.29447
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.26799
TLE5 TLE family member 5, transcriptional modulator -2.24587
MLF2 myeloid leukemia factor 2 -2.20841
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.15857
ALDOC aldolase C, fructose-bisphosphate -2.15693
STRADA STE20-related kinase adaptor alpha -2.15255
ATP5F1E ATP synthase F1 subunit epsilon -2.14133
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.13018
STXBP2 syntaxin binding protein 2 -2.12874
DGCR6L DiGeorge syndrome critical region gene 6-like -2.1077
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.09862
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.0899
RBM34 RNA binding motif protein 34 -2.06804
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.05158