CRCGN016_MCF10A.WT.HP_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-diaminotoluene 32.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

118 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 7.00429
OLFML2B olfactomedin-like 2B 4.59265
PEX11A peroxisomal biogenesis factor 11 alpha 4.42541
HBB hemoglobin, beta 3.98972
AGR2 anterior gradient 2 3.79984
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.39076
CGRRF1 cell growth regulator with ring finger domain 1 3.07679
SYNGAP1 synaptic Ras GTPase activating protein 1 2.63115
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.60354
UBE2E1 ubiquitin-conjugating enzyme E2E 1 2.60327
ELOVL2 ELOVL fatty acid elongase 2 2.55775
MFN1 mitofusin 1 2.48561
GCA grancalcin, EF-hand calcium binding protein 2.48036
IFT81 intraflagellar transport 81 2.37042
PDGFRL platelet-derived growth factor receptor-like 2.33636
TDG thymine-DNA glycosylase 2.30794
NDC1 NDC1 transmembrane nucleoporin 2.30425
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.27891
CAB39 calcium binding protein 39 2.2756
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.24509
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.23873
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.23106
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.22717
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.20892
SHTN1 shootin 1 2.1726
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.14686
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.14626
GMPR2 guanosine monophosphate reductase 2 2.12248
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.0995
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.08307
SLC43A3 solute carrier family 43, member 3 2.05475
RHOQ ras homolog family member Q 2.04656
CIAO2B cytosolic iron-sulfur assembly component 2B 2.04417
SMAP1 small ArfGAP 1 2.04394
TOP2B topoisomerase (DNA) II beta 180kDa 2.04098
STAT5A signal transducer and activator of transcription 5A 2.02985
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.02627
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.02361
TBPL1 TBP-like 1 2.02308
PBK PDZ binding kinase 2.00573
CR2 complement component (3d/Epstein Barr virus) receptor 2 2.00426

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.77036
RNF167 ring finger protein 167 -5.6661
NPDC1 neural proliferation, differentiation and control, 1 -4.95699
COG7 component of oligomeric golgi complex 7 -4.67834
DSG2 desmoglein 2 -4.61244
BASP1 brain abundant, membrane attached signal protein 1 -4.57806
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.5129
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.29831
COG2 component of oligomeric golgi complex 2 -4.26932
JMJD6 jumonji domain containing 6 -3.72487
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.66137
TENT4A terminal nucleotidyltransferase 4A -3.45265
BFAR bifunctional apoptosis regulator -3.21378
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -3.15768
MXRA7 matrix-remodelling associated 7 -3.14091
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.99554
MSMO1 methylsterol monooxygenase 1 -2.90446
CANT1 calcium activated nucleotidase 1 -2.87792
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.85378
PFN1 profilin 1 -2.7518
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.74201
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.60515
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.59379
HIRIP3 HIRA interacting protein 3 -2.56465
CXCR3 chemokine (C-X-C motif) receptor 3 -2.53392
GZMM granzyme M (lymphocyte met-ase 1) -2.52369
UBN1 ubinuclein 1 -2.47062
SDF2L1 stromal cell-derived factor 2-like 1 -2.45399
TTC13 tetratricopeptide repeat domain 13 -2.43202
MPDU1 mannose-P-dolichol utilization defect 1 -2.43072
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.41292
HMOX2 heme oxygenase 2 -2.40546
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.39564
PARN poly(A)-specific ribonuclease -2.34867
SMAD6 SMAD family member 6 -2.34567
TBCC tubulin folding cofactor C -2.34208
RUSF1 RUS family member 1 -2.33604
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.30433
ZNF500 zinc finger protein 500 -2.2833
PTCD1 pentatricopeptide repeat domain 1 -2.24645
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 -2.23492
FN3KRP fructosamine 3 kinase related protein -2.22667
RNF187 ring finger protein 187 -2.22337
BTN3A1 butyrophilin, subfamily 3, member A1 -2.22284
LAX1 lymphocyte transmembrane adaptor 1 -2.20604
KDM8 lysine (K)-specific demethylase 8 -2.20278
MUS81 MUS81 structure-specific endonuclease subunit -2.19515
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.17532
RAB8A RAB8A, member RAS oncogene family -2.16718
TMEM63A transmembrane protein 63A -2.15655
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.14978
RBBP6 retinoblastoma binding protein 6 -2.11173
SGF29 SAGA complex associated factor 29 -2.10667
ADORA1 adenosine A1 receptor -2.10602
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.10387
EML2 echinoderm microtubule associated protein like 2 -2.09508
CPTP ceramide-1-phosphate transfer protein -2.09411
DVL2 dishevelled segment polarity protein 2 -2.09131
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.08289
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.07568
PTMS parathymosin -2.06407
ADGRL1 adhesion G protein-coupled receptor L1 -2.0632
RBP3 retinol binding protein 3, interstitial -2.06219
DNASE1L2 deoxyribonuclease I-like 2 -2.0575
RBM34 RNA binding motif protein 34 -2.05729
JMJD4 jumonji domain containing 4 -2.04374
CXCL13 chemokine (C-X-C motif) ligand 13 -2.04026
ZNF574 zinc finger protein 574 -2.03723
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.03586
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.0294
GAST gastrin -2.02754
MPHOSPH8 M-phase phosphoprotein 8 -2.02187
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.02144
ZNF668 zinc finger protein 668 -2.0193
HAPLN1 hyaluronan and proteoglycan link protein 1 -2.01784
FOXJ2 forkhead box J2 -2.01296
NDEL1 nudE neurodevelopment protein 1-like 1 -2.00779