CRCGN016_MCF10A.WT.HP_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyphenazine 100.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALAS1 5'-aminolevulinate synthase 1 6.33793
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.82237
AGR2 anterior gradient 2 5.80224
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.30086
AARS1 alanyl-tRNA synthetase 1 4.17537
E2F2 E2F transcription factor 2 4.16685
GLRX glutaredoxin (thioltransferase) 3.86725
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.75934
MSRA methionine sulfoxide reductase A 3.61771
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.47491
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.46624
PHGDH phosphoglycerate dehydrogenase 3.27009
TRIB3 tribbles pseudokinase 3 3.12906
CDPF1 cysteine-rich, DPF motif domain containing 1 3.06965
NLRP4 NLR family, pyrin domain containing 4 3.03291
CTSL cathepsin L 2.96902
TXNRD1 thioredoxin reductase 1 2.9372
CHMP4B charged multivesicular body protein 4B 2.92174
EPN2 epsin 2 2.82957
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.79025
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.76306
RBKS ribokinase 2.71902
RAP1GAP RAP1 GTPase activating protein 2.66884
GSTZ1 glutathione S-transferase zeta 1 2.59737
CNRIP1 cannabinoid receptor interacting protein 1 2.59331
NUCB2 nucleobindin 2 2.56822
KCTD13 potassium channel tetramerization domain containing 13 2.47085
SKIC2 SKI2 subunit of superkiller complex 2.44127
UGDH UDP-glucose 6-dehydrogenase 2.32961
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.31484
GPC1 glypican 1 2.3051
CNPY3 canopy FGF signaling regulator 3 2.30253
PYCR1 pyrroline-5-carboxylate reductase 1 2.28527
COPS7A COP9 signalosome subunit 7A 2.27723
APOLD1 apolipoprotein L domain containing 1 2.25342
PSAT1 phosphoserine aminotransferase 1 2.2396
FLG filaggrin 2.22767
SLURP1 secreted LY6/PLAUR domain containing 1 2.20772
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.20178
CUL7 cullin 7 2.19659
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.15793
GARS1 glycyl-tRNA synthetase 1 2.14303
GPR17 G protein-coupled receptor 17 2.1402
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.13606
ADRA2C adrenoceptor alpha 2C 2.10666
DOCK6 dedicator of cytokinesis 6 2.10545
TRIB1 tribbles pseudokinase 1 2.10372
DGKB diacylglycerol kinase, beta 90kDa 2.09679
CFAP44 cilia and flagella associated protein 44 2.07176
VSIG2 V-set and immunoglobulin domain containing 2 2.05691
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.05583
ADGRB2 adhesion G protein-coupled receptor B2 2.05269
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.0423
SARS1 seryl-tRNA synthetase 1 2.04182
IGHMBP2 immunoglobulin mu binding protein 2 2.03699
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.0309
TMEM254 transmembrane protein 254 2.01934
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.01572
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.01534
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.01471
LIN7A lin-7 homolog A (C. elegans) 2.01344
ALOXE3 arachidonate lipoxygenase 3 2.01085
ELOVL4 ELOVL fatty acid elongase 4 2.0082
SYNGAP1 synaptic Ras GTPase activating protein 1 2.00583

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -5.51498
STMN1 stathmin 1 -4.74036
PLK1 polo-like kinase 1 -4.22123
TUBB6 tubulin, beta 6 class V -3.76522
KIF20A kinesin family member 20A -3.71892
PSRC1 proline/serine-rich coiled-coil 1 -3.68771
AURKB aurora kinase B -3.09584
AURKA aurora kinase A -3.05579
HOXA5 homeobox A5 -3.00818
CCNA2 cyclin A2 -2.90938
CDC20 cell division cycle 20 -2.70984
KIF14 kinesin family member 14 -2.60625
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.59816
SMNDC1 survival motor neuron domain containing 1 -2.56721
BIRC5 baculoviral IAP repeat containing 5 -2.55689
TOP2A topoisomerase (DNA) II alpha 170kDa -2.49756
FASTKD5 FAST kinase domains 5 -2.47449
KIF11 kinesin family member 11 -2.4009
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.39223
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.3918
CDCA3 cell division cycle associated 3 -2.37579
NCAPD2 non-SMC condensin I complex, subunit D2 -2.32551
PCNA proliferating cell nuclear antigen -2.28245
TPX2 TPX2, microtubule-associated -2.24735
IFRD2 interferon-related developmental regulator 2 -2.22274
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -2.22082
SAP30 Sin3A-associated protein, 30kDa -2.21906
OIP5 Opa interacting protein 5 -2.2182
NUP88 nucleoporin 88kDa -2.1918
ALDOC aldolase C, fructose-bisphosphate -2.19102
DYNLT3 dynein, light chain, Tctex-type 3 -2.18279
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.15818
MCM3 minichromosome maintenance complex component 3 -2.13138
PER3 period circadian clock 3 -2.09694
MCM10 minichromosome maintenance complex component 10 -2.07638
BAG1 BCL2-associated athanogene -2.07292
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.06803
ENOPH1 enolase-phosphatase 1 -2.06375
TMEM97 transmembrane protein 97 -2.04619
NUSAP1 nucleolar and spindle associated protein 1 -2.03488
CCNB2 cyclin B2 -2.0322
CCNB1 cyclin B1 -2.02141
ASF1B anti-silencing function 1B histone chaperone -2.01447
CDK1 cyclin-dependent kinase 1 -2.00846