CRCGN016_MCF10A.WT.HP_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trichlorophenoxyacetic acid 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.03879
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.88504
NOTCH1 notch 1 3.59361
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.41925
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.07613
PPARG peroxisome proliferator-activated receptor gamma 3.01616
OLFML2B olfactomedin-like 2B 2.88792
SPAG4 sperm associated antigen 4 2.8413
KDM5A lysine (K)-specific demethylase 5A 2.68685
MTA2 metastasis associated 1 family, member 2 2.67896
ACAA1 acetyl-CoA acyltransferase 1 2.62246
NUTF2 nuclear transport factor 2 2.52877
CEPT1 choline/ethanolamine phosphotransferase 1 2.35588
GSTK1 glutathione S-transferase kappa 1 2.34361
WDR76 WD repeat domain 76 2.33655
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.27118
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.23677
RBBP5 retinoblastoma binding protein 5 2.23217
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.17937
MOCS3 molybdenum cofactor synthesis 3 2.15384
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.11159
HYOU1 hypoxia up-regulated 1 2.06213
PRPF39 pre-mRNA processing factor 39 2.03125

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.34689
CANT1 calcium activated nucleotidase 1 -4.36215
BASP1 brain abundant, membrane attached signal protein 1 -4.33098
DDRGK1 DDRGK domain containing 1 -3.51354
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.23615
CHMP4B charged multivesicular body protein 4B -3.13035
ARID4B AT rich interactive domain 4B (RBP1-like) -2.6835
S100A8 S100 calcium binding protein A8 -2.65138
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.64753
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.62011
SNPH syntaphilin -2.58499
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.58123
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.57651
KIF14 kinesin family member 14 -2.51833
MYOD1 myogenic differentiation 1 -2.494
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.4507
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.38205
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.33029
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.29963
PANK2 pantothenate kinase 2 -2.27413
ZNF133 zinc finger protein 133 -2.24679
MACF1 microtubule-actin crosslinking factor 1 -2.2149
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.20727
TPSG1 tryptase gamma 1 -2.17157
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -2.15475
RXYLT1 ribitol xylosyltransferase 1 -2.14875
NSFL1C NSFL1 (p97) cofactor (p47) -2.10678
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.0727
CENPB centromere protein B, 80kDa -2.06916
SNX5 sorting nexin 5 -2.03413
KIF16B kinesin family member 16B -2.02657
CCNP cyclin P -2.01738
TCTA T-cell leukemia translocation altered -2.01701