CRCGN016_MCF10A.WT.HP_24H:D21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acronycine 11.18 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

275 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:D21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.25864
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 6.95724
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 6.61332
RGS2 regulator of G-protein signaling 2 6.43564
WIF1 WNT inhibitory factor 1 5.779
LRP10 low density lipoprotein receptor-related protein 10 5.46919
STAP2 signal transducing adaptor family member 2 5.36063
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.32873
TICAM1 toll-like receptor adaptor molecule 1 4.94308
SYNGAP1 synaptic Ras GTPase activating protein 1 4.84788
SQOR sulfide quinone oxidoreductase 4.63088
KLHL21 kelch-like family member 21 4.2102
MVP major vault protein 4.12896
NCK1 NCK adaptor protein 1 4.08301
HSPB1 heat shock 27kDa protein 1 4.01165
CHIC2 cysteine-rich hydrophobic domain 2 3.7914
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.70661
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 3.64198
MINDY1 MINDY lysine 48 deubiquitinase 1 3.63829
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.58751
CAPN1 calpain 1, (mu/I) large subunit 3.57528
TP53BP2 tumor protein p53 binding protein 2 3.47416
ERBB3 erb-b2 receptor tyrosine kinase 3 3.45623
MUC1 mucin 1, cell surface associated 3.36951
KCTD9 potassium channel tetramerization domain containing 9 3.35921
SPRR1B small proline-rich protein 1B 3.26737
CLDN7 claudin 7 3.20757
CLDN4 claudin 4 3.19288
GLRX glutaredoxin (thioltransferase) 3.17519
USP6NL USP6 N-terminal like 3.1379
VAT1 vesicle amine transport 1 3.11949
OXSR1 oxidative stress responsive 1 3.11627
KRT16 keratin 16, type I 3.07253
KRT6B keratin 6B, type II 3.01146
CRCT1 cysteine-rich C-terminal 1 2.99276
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.94068
TJP1 tight junction protein 1 2.93404
BAG3 BCL2-associated athanogene 3 2.92585
PI3 peptidase inhibitor 3, skin-derived 2.89478
CGRRF1 cell growth regulator with ring finger domain 1 2.88456
CAB39 calcium binding protein 39 2.871
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.72558
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.72413
BMAL2 basic helix-loop-helix ARNT like 2 2.72157
KRT6A keratin 6A, type II 2.721
ZNF750 zinc finger protein 750 2.66701
EPS8L2 EPS8-like 2 2.63154
PRSS8 protease, serine, 8 2.62406
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.62186
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.61743
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.6159
ITPKC inositol-trisphosphate 3-kinase C 2.60518
SOX4 SRY (sex determining region Y)-box 4 2.60168
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.59502
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.59014
TSPAN1 tetraspanin 1 2.58875
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.57718
SPRR1A small proline-rich protein 1A 2.56842
CLIC4 chloride intracellular channel 4 2.55396
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.54853
CDK7 cyclin-dependent kinase 7 2.52933
IL4R interleukin 4 receptor 2.51838
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.51505
RAB25 RAB25, member RAS oncogene family 2.50452
CYB5R2 cytochrome b5 reductase 2 2.50384
IL1B interleukin 1, beta 2.4988
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.49055
CORO1A coronin, actin binding protein, 1A 2.47974
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.47816
IL36G interleukin 36, gamma 2.47519
ARMCX3 armadillo repeat containing, X-linked 3 2.44124
LAMC2 laminin, gamma 2 2.43601
PLAUR plasminogen activator, urokinase receptor 2.42773
EMP1 epithelial membrane protein 1 2.42104
GIPC1 GIPC PDZ domain containing family, member 1 2.40737
INAVA innate immunity activator 2.40278
FOSL1 FOS-like antigen 1 2.38721
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.38676
WDR44 WD repeat domain 44 2.38101
LRRC8E leucine rich repeat containing 8 family, member E 2.37515
CLTB clathrin, light chain B 2.36977
ARMCX6 armadillo repeat containing, X-linked 6 2.36789
DYNLT3 dynein, light chain, Tctex-type 3 2.36232
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.36005
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.35072
KLK10 kallikrein-related peptidase 10 2.34998
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.34246
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.33034
GRAMD2B GRAM domain containing 2B 2.32248
KLK6 kallikrein-related peptidase 6 2.31804
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.31621
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.29526
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.29402
TUBB6 tubulin, beta 6 class V 2.29363
TMPRSS11E transmembrane protease, serine 11E 2.29148
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.28928
LOC128966597 MAL-like protein 2.28293
ZNF365 zinc finger protein 365 2.28066
RAB9A RAB9A, member RAS oncogene family 2.27726
PYGB phosphorylase, glycogen; brain 2.27128
KLF5 Kruppel-like factor 5 (intestinal) 2.26928
SAMD9 sterile alpha motif domain containing 9 2.26741
LYPD3 LY6/PLAUR domain containing 3 2.26556
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.25714
BHLHE40 basic helix-loop-helix family, member e40 2.24513
SPRR3 small proline-rich protein 3 2.24394
CDA cytidine deaminase 2.22989
VGLL4 vestigial-like family member 4 2.20849
SPRR2B small proline-rich protein 2B 2.20701
ARID5B AT rich interactive domain 5B (MRF1-like) 2.20007
INPP1 inositol polyphosphate-1-phosphatase 2.19693
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.19685
LSR lipolysis stimulated lipoprotein receptor 2.19566
CD59 CD59 molecule, complement regulatory protein 2.19191
PDIA5 protein disulfide isomerase family A, member 5 2.18989
SNX16 sorting nexin 16 2.18909
JUP junction plakoglobin 2.18415
ANXA3 annexin A3 2.18334
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.17386
TGM1 transglutaminase 1 2.17264
ETHE1 ethylmalonic encephalopathy 1 2.17029
RASAL2 RAS protein activator like 2 2.16692
PLSCR1 phospholipid scramblase 1 2.16606
DDA1 DET1 and DDB1 associated 1 2.16585
S100P S100 calcium binding protein P 2.15778
PPL periplakin 2.15385
GMPPA GDP-mannose pyrophosphorylase A 2.13074
FRYL FRY-like 2.12205
IL1A interleukin 1, alpha 2.11807
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.11473
HBEGF heparin-binding EGF-like growth factor 2.09572
FGD6 FYVE, RhoGEF and PH domain containing 6 2.09411
UBA1 ubiquitin-like modifier activating enzyme 1 2.08644
EPHA2 EPH receptor A2 2.0859
RNASE4 ribonuclease, RNase A family, 4 2.08426
PYCARD PYD and CARD domain containing 2.07941
MTMR11 myotubularin related protein 11 2.07832
FRMD4B FERM domain containing 4B 2.07669
AGR2 anterior gradient 2 2.07189
BCL10 B-cell CLL/lymphoma 10 2.06905
IER3 immediate early response 3 2.06783
ITGB4 integrin, beta 4 2.06481
DSG3 desmoglein 3 2.05812
ARF4 ADP-ribosylation factor 4 2.05204
ITPRID2 ITPR interacting domain containing 2 2.04449
MSRA methionine sulfoxide reductase A 2.04433
OPTN optineurin 2.03991
IRF6 interferon regulatory factor 6 2.0332
EPN2 epsin 2 2.0286
CSRNP2 cysteine-serine-rich nuclear protein 2 2.02826
STX7 syntaxin 7 2.02561
RIOK3 RIO kinase 3 2.0225
PPARD peroxisome proliferator-activated receptor delta 2.02146
RHCG Rh family, C glycoprotein 2.02098
ELL2 elongation factor, RNA polymerase II, 2 2.01102
STX8 syntaxin 8 2.00882

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -6.26468
ECH1 enoyl CoA hydratase 1, peroxisomal -5.86535
MSMO1 methylsterol monooxygenase 1 -5.82449
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.16043
NCAPD2 non-SMC condensin I complex, subunit D2 -4.83081
LBR lamin B receptor -3.94155
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.86814
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.74664
CDK4 cyclin-dependent kinase 4 -3.57495
INSIG1 insulin induced gene 1 -3.56475
CD320 CD320 molecule -3.47574
CDC45 cell division cycle 45 -3.43777
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.25018
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.23611
TRAP1 TNF receptor-associated protein 1 -3.21978
SOAT2 sterol O-acyltransferase 2 -3.20402
ENTR1 endosome associated trafficking regulator 1 -3.15756
SH3D19 SH3 domain containing 19 -3.15149
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -3.11462
TSC22D3 TSC22 domain family, member 3 -3.11096
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.10363
CDC7 cell division cycle 7 -3.09083
WDR3 WD repeat domain 3 -3.05526
TKT transketolase -3.03887
SCYL3 SCY1-like 3 (S. cerevisiae) -3.01796
PARP1 poly (ADP-ribose) polymerase 1 -2.94767
MRPS2 mitochondrial ribosomal protein S2 -2.85393
UBE2C ubiquitin-conjugating enzyme E2C -2.77815
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.7676
FANCC Fanconi anemia, complementation group C -2.74868
ISOC1 isochorismatase domain containing 1 -2.74504
PSRC1 proline/serine-rich coiled-coil 1 -2.73907
MELK maternal embryonic leucine zipper kinase -2.59098
SESN1 sestrin 1 -2.57677
USP19 ubiquitin specific peptidase 19 -2.57547
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.56267
TLCD3A TLC domain containing 3A -2.52732
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.50816
MTO1 mitochondrial tRNA translation optimization 1 -2.49005
ETFB electron-transfer-flavoprotein, beta polypeptide -2.48272
MEPCE methylphosphate capping enzyme -2.47328
ZNF783 zinc finger family member 783 -2.47276
NOP14 NOP14 nucleolar protein -2.45288
RBM23 RNA binding motif protein 23 -2.44149
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.44058
SCML2 sex comb on midleg-like 2 (Drosophila) -2.43764
ARL4A ADP-ribosylation factor-like 4A -2.4306
PRR3 proline rich 3 -2.42685
CISD1 CDGSH iron sulfur domain 1 -2.42083
STMN1 stathmin 1 -2.41885
TWNK twinkle mtDNA helicase -2.41224
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.39421
PRR7 proline rich 7 (synaptic) -2.38601
CHST10 carbohydrate sulfotransferase 10 -2.38466
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.37669
MCM3 minichromosome maintenance complex component 3 -2.36245
PKD2L1 polycystic kidney disease 2-like 1 -2.35502
PTCD1 pentatricopeptide repeat domain 1 -2.34407
WDR77 WD repeat domain 77 -2.31452
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -2.31022
SCARB1 scavenger receptor class B, member 1 -2.3078
TP53 tumor protein p53 -2.29633
MAP7D3 MAP7 domain containing 3 -2.26553
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.26542
RUVBL1 RuvB-like AAA ATPase 1 -2.2644
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.26418
PARG poly (ADP-ribose) glycohydrolase -2.25227
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.23471
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.22859
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.21299
ZNF45 zinc finger protein 45 -2.20381
NUP133 nucleoporin 133kDa -2.19382
OSGEP O-sialoglycoprotein endopeptidase -2.18498
ZNF76 zinc finger protein 76 -2.17919
TACC3 transforming, acidic coiled-coil containing protein 3 -2.17757
WDR73 WD repeat domain 73 -2.17668
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.16642
CPZ carboxypeptidase Z -2.15755
IPO9 importin 9 -2.15332
RPL10L ribosomal protein L10-like -2.14943
DHCR7 7-dehydrocholesterol reductase -2.14929
JADE2 jade family PHD finger 2 -2.14779
NUP85 nucleoporin 85kDa -2.14647
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -2.14408
CEP192 centrosomal protein 192kDa -2.14038
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.13559
BPHL biphenyl hydrolase-like (serine hydrolase) -2.1318
RAD54L RAD54-like (S. cerevisiae) -2.13115
FANCG Fanconi anemia, complementation group G -2.12899
KAT2A K(lysine) acetyltransferase 2A -2.11129
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.10694
CCP110 centriolar coiled coil protein 110kDa -2.10664
SETD6 SET domain containing 6 -2.10471
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.10072
DHODH dihydroorotate dehydrogenase (quinone) -2.09266
FADS2 fatty acid desaturase 2 -2.08852
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.08257
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.08039
HADH hydroxyacyl-CoA dehydrogenase -2.07972
ATF5 activating transcription factor 5 -2.07951
RIOX1 ribosomal oxygenase 1 -2.07858
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.07799
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.07447
SQLE squalene epoxidase -2.07102
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.06095
GDF15 growth differentiation factor 15 -2.04902
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.04556
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.04403
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.04289
DPH2 DPH2 homolog (S. cerevisiae) -2.03975
SURF2 surfeit 2 -2.03493
MPHOSPH9 M-phase phosphoprotein 9 -2.03296
INO80D INO80 complex subunit D -2.03088
MAPK12 mitogen-activated protein kinase 12 -2.03032
EXO1 exonuclease 1 -2.02411
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.02128
TMEM97 transmembrane protein 97 -2.01297
AURKC aurora kinase C -2.00015
CIRBP cold inducible RNA binding protein -2.00006