CRCGN016_MCF10A.WT.HP_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 101.47 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.462
UGDH UDP-glucose 6-dehydrogenase 3.33013
FBXL12 F-box and leucine-rich repeat protein 12 3.27732
TRIB3 tribbles pseudokinase 3 3.10839
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.03919
MSRA methionine sulfoxide reductase A 2.93954
RTN2 reticulon 2 2.88508
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.82974
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.72534
WDR7 WD repeat domain 7 2.65223
CRELD2 cysteine-rich with EGF-like domains 2 2.55161
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.52818
GLRX glutaredoxin (thioltransferase) 2.51112
CGRRF1 cell growth regulator with ring finger domain 1 2.45629
SHISAL1 shisa like 1 2.33464
CERK ceramide kinase 2.26135
S100A4 S100 calcium binding protein A4 2.22517
PPOX protoporphyrinogen oxidase 2.22159
INSIG1 insulin induced gene 1 2.22141
PMM2 phosphomannomutase 2 2.20999
GREM1 gremlin 1, DAN family BMP antagonist 2.17277
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.16318
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.16184
ACVRL1 activin A receptor type II-like 1 2.14697
IL1B interleukin 1, beta 2.12956
RAP1GAP RAP1 GTPase activating protein 2.09496
NIT1 nitrilase 1 2.04546
RTN1 reticulon 1 2.02865
ADGRL4 adhesion G protein-coupled receptor L4 2.00295

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.39912
HOXA5 homeobox A5 -3.69038
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.13441
LDHD lactate dehydrogenase D -2.9189
STMN1 stathmin 1 -2.88394
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.60321
TRAP1 TNF receptor-associated protein 1 -2.58951
HEATR1 HEAT repeat containing 1 -2.31217
ALDOC aldolase C, fructose-bisphosphate -2.29247
TP53 tumor protein p53 -2.28666
PLK1 polo-like kinase 1 -2.25505
ZNF443 zinc finger protein 443 -2.24011
OXCT1 3-oxoacid CoA transferase 1 -2.2344
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.22379
CD81 CD81 molecule -2.20853
KDM3A lysine (K)-specific demethylase 3A -2.20144
RALGDS ral guanine nucleotide dissociation stimulator -2.17652
CDC20 cell division cycle 20 -2.12611
RGS2 regulator of G-protein signaling 2 -2.12454
HSPB1 heat shock 27kDa protein 1 -2.09886
MRPS16 mitochondrial ribosomal protein S16 -2.09613
TOMM70 translocase of outer mitochondrial membrane 70 -2.09549
IRX5 iroquois homeobox 5 -2.09133
JPT2 Jupiter microtubule associated homolog 2 -2.026
ENOPH1 enolase-phosphatase 1 -2.02195