CRCGN016_MCF10A.WT.HP_24H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 5.03299
AGR2 anterior gradient 2 4.85817
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.75735
SNAP25 synaptosomal-associated protein, 25kDa 3.42449
PNKP polynucleotide kinase 3'-phosphatase 3.36434
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.11972
MCUR1 mitochondrial calcium uniporter regulator 1 2.86162
LOC122526780 uncharacterized LOC122526780 2.74653
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.65213
GATA2 GATA binding protein 2 2.62987
IL1B interleukin 1, beta 2.60941
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.57211
TBPL1 TBP-like 1 2.56068
MAMLD1 mastermind-like domain containing 1 2.53441
RAB31 RAB31, member RAS oncogene family 2.51428
HMGA2 high mobility group AT-hook 2 2.26878

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -4.94561
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.63713
LAP3 leucine aminopeptidase 3 -3.34022
HMG20B high mobility group 20B -3.20719
GDF15 growth differentiation factor 15 -3.14818
RPA3 replication protein A3, 14kDa -3.13632
TEX10 testis expressed 10 -3.09929
RALGDS ral guanine nucleotide dissociation stimulator -2.91147
MAPK13 mitogen-activated protein kinase 13 -2.84345
ACOT9 acyl-CoA thioesterase 9 -2.75165
OXA1L oxidase (cytochrome c) assembly 1-like -2.72487
CXCL14 chemokine (C-X-C motif) ligand 14 -2.56309
MT1X metallothionein 1X -2.54914
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.45609
STX17 syntaxin 17 -2.31482
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.22154
TYRP1 tyrosinase-related protein 1 -2.18589
AMDHD2 amidohydrolase domain containing 2 -2.18423
RNPS1 RNA binding protein S1, serine-rich domain -2.18206
MSRB1 methionine sulfoxide reductase B1 -2.18093
STXBP2 syntaxin binding protein 2 -2.15523
LORICRIN loricrin cornified envelope precursor protein -2.14181
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -2.08978
RANBP17 RAN binding protein 17 -2.0708