CRCGN016_MCF10A.WT.HP_24H:E04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenyl-p-phenylenediamine 100.46 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5D lysine (K)-specific demethylase 5D 4.23047
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.89822
CDCA4 cell division cycle associated 4 3.46113
HBA1 hemoglobin, alpha 1 3.41516
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.99213
SNX11 sorting nexin 11 2.87579
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.79518
LAGE3 L antigen family, member 3 2.79505
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.67284
USP9Y ubiquitin specific peptidase 9, Y-linked 2.62217
TLR4 toll-like receptor 4 2.6053
INPP1 inositol polyphosphate-1-phosphatase 2.56035
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.44774
PILRB paired immunoglobin-like type 2 receptor beta 2.27454
CEP170 centrosomal protein 170kDa 2.12847
NCK2 NCK adaptor protein 2 2.05881
ARHGAP1 Rho GTPase activating protein 1 2.03195
CGRRF1 cell growth regulator with ring finger domain 1 2.03112
GLRX5 glutaredoxin 5 2.01414
ABHD14A abhydrolase domain containing 14A 2.0116

decreased expression

Symbol Name Standardized Value
RPA3 replication protein A3, 14kDa -5.03534
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -4.1402
UBE2C ubiquitin-conjugating enzyme E2C -3.60559
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.35917
KDM5C lysine (K)-specific demethylase 5C -3.27196
PLK1 polo-like kinase 1 -3.15859
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.11065
SMC1A structural maintenance of chromosomes 1A -2.97303
KDM6A lysine (K)-specific demethylase 6A -2.9165
KDM3A lysine (K)-specific demethylase 3A -2.87565
TOP2A topoisomerase (DNA) II alpha 170kDa -2.85592
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.79189
PSRC1 proline/serine-rich coiled-coil 1 -2.69656
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.63811
MTERF3 mitochondrial transcription termination factor 3 -2.62493
HMG20B high mobility group 20B -2.47123
S100A8 S100 calcium binding protein A8 -2.41908
UBA1 ubiquitin-like modifier activating enzyme 1 -2.32547
TRAP1 TNF receptor-associated protein 1 -2.29082
COXFA4 cytochrome c oxidase associated subunit FA4 -2.25537
EFNB1 ephrin-B1 -2.22958
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.20212
PUDP pseudouridine 5'-phosphatase -2.1988
NPDC1 neural proliferation, differentiation and control, 1 -2.18079
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.09549
GADD45B growth arrest and DNA-damage-inducible, beta -2.08686
USP9X ubiquitin specific peptidase 9, X-linked -2.07689
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.06007