CRCGN016_MCF10A.WT.HP_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenyl-p-phenylenediamine 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

107 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.99109
CXCL2 chemokine (C-X-C motif) ligand 2 5.07395
GPER1 G protein-coupled estrogen receptor 1 4.67792
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.56552
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.52254
CDCA4 cell division cycle associated 4 4.342
EVL Enah/Vasp-like 4.08565
CEP57 centrosomal protein 57kDa 3.82029
FYN FYN proto-oncogene, Src family tyrosine kinase 3.54099
TBX2 T-box 2 3.13156
COQ8A coenzyme Q8A 2.93687
CTSL cathepsin L 2.92395
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.70913
CD248 CD248 molecule, endosialin 2.67229
NCK2 NCK adaptor protein 2 2.65716
RPAIN RPA interacting protein 2.61574
CXCL3 chemokine (C-X-C motif) ligand 3 2.61068
TPD52L2 tumor protein D52-like 2 2.60795
CSPG4 chondroitin sulfate proteoglycan 4 2.48513
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.48334
SKIC8 SKI8 subunit of superkiller complex 2.45077
TMPRSS11E transmembrane protease, serine 11E 2.44046
RCOR1 REST corepressor 1 2.37093
FBXO11 F-box protein 11 2.35268
ADGRG6 adhesion G protein-coupled receptor G6 2.31229
DLL3 delta-like 3 (Drosophila) 2.30228
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.29413
PLS1 plastin 1 2.26528
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.25933
SLC35F5 solute carrier family 35, member F5 2.21249
CADM1 cell adhesion molecule 1 2.18951
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.16249
ENDOD1 endonuclease domain containing 1 2.15153
CDA cytidine deaminase 2.14176
RPN1 ribophorin I 2.12591
PDIA5 protein disulfide isomerase family A, member 5 2.12272
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.12249
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 2.11337
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.10064
CLIP3 CAP-GLY domain containing linker protein 3 2.10008
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.08599
FGD1 FYVE, RhoGEF and PH domain containing 1 2.06978
COL5A3 collagen, type V, alpha 3 2.06564
TENM1 teneurin transmembrane protein 1 2.03183
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.02828
CHN1 chimerin 1 2.01679

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.03187
CCNB2 cyclin B2 -5.47867
MSMO1 methylsterol monooxygenase 1 -5.14277
CD320 CD320 molecule -5.08079
RNF167 ring finger protein 167 -4.98139
DYNLT3 dynein, light chain, Tctex-type 3 -4.96528
NT5DC2 5'-nucleotidase domain containing 2 -4.54481
LAP3 leucine aminopeptidase 3 -4.37233
KIF14 kinesin family member 14 -4.32319
DCK deoxycytidine kinase -4.09864
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.01816
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -3.97732
S100A8 S100 calcium binding protein A8 -3.91771
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.78899
KIF20A kinesin family member 20A -3.78422
AMDHD2 amidohydrolase domain containing 2 -3.77734
RGS2 regulator of G-protein signaling 2 -3.77587
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.67989
PFN1 profilin 1 -3.60451
ANXA2 annexin A2 -3.36345
SESN1 sestrin 1 -3.31692
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.09614
EXOSC4 exosome component 4 -3.0658
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.03755
RPA3 replication protein A3, 14kDa -2.8124
UBE2C ubiquitin-conjugating enzyme E2C -2.71077
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.65936
CDK4 cyclin-dependent kinase 4 -2.62406
EPHB4 EPH receptor B4 -2.62012
HOXB3 homeobox B3 -2.6108
SPRED2 sprouty-related, EVH1 domain containing 2 -2.56479
TCF15 transcription factor 15 (basic helix-loop-helix) -2.53644
CLSTN3 calsyntenin 3 -2.52586
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.49789
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.49462
PRSS23 protease, serine, 23 -2.42923
YME1L1 YME1-like 1 ATPase -2.39671
FAM3C family with sequence similarity 3, member C -2.35616
CHPF chondroitin polymerizing factor -2.33469
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome -2.32426
ARMC7 armadillo repeat containing 7 -2.32273
FOS FBJ murine osteosarcoma viral oncogene homolog -2.29111
LIPG lipase, endothelial -2.2881
ZFP36L2 ZFP36 ring finger protein-like 2 -2.24006
SLC46A3 solute carrier family 46, member 3 -2.2321
GDF2 growth differentiation factor 2 -2.21104
HDAC2 histone deacetylase 2 -2.19274
CTSW cathepsin W -2.16085
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.16063
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.1595
GADD45B growth arrest and DNA-damage-inducible, beta -2.14872
GSDMD gasdermin D -2.14834
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.13833
TROAP trophinin associated protein -2.10712
HOMER3 homer scaffolding protein 3 -2.09227
KIF1A kinesin family member 1A -2.07294
KLHDC4 kelch domain containing 4 -2.07286
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.05465
ETV7 ets variant 7 -2.04251
TPPP tubulin polymerization promoting protein -2.00683
ZBTB5 zinc finger and BTB domain containing 5 -2.00257