CRCGN016_MCF10A.WT.HP_24H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 101.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.0163
COMP cartilage oligomeric matrix protein 5.37566
TLR4 toll-like receptor 4 4.38198
AGR2 anterior gradient 2 3.96405
SPAG4 sperm associated antigen 4 3.6395
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.62234
CXCR4 chemokine (C-X-C motif) receptor 4 3.60595
ACLY ATP citrate lyase 3.07433
MAMLD1 mastermind-like domain containing 1 3.03962
CNRIP1 cannabinoid receptor interacting protein 1 2.78751
LYN LYN proto-oncogene, Src family tyrosine kinase 2.73299
ANO10 anoctamin 10 2.38256
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.2714
STK10 serine/threonine kinase 10 2.24931
PAQR3 progestin and adipoQ receptor family member III 2.19761
PANK2 pantothenate kinase 2 2.1731
FBXO11 F-box protein 11 2.14505
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 2.13129
SLC35F5 solute carrier family 35, member F5 2.12179
C3AR1 complement component 3a receptor 1 2.11253
ZNF492 zinc finger protein 492 2.11018
CADM1 cell adhesion molecule 1 2.07515
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.07313
THUMPD2 THUMP domain containing 2 2.06126
ZSCAN16 zinc finger and SCAN domain containing 16 2.04949
MAPK9 mitogen-activated protein kinase 9 2.0271
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.02364
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.02083
FSD1 fibronectin type III and SPRY domain containing 1 2.00658

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.08127
RNF167 ring finger protein 167 -5.12028
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.45143
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.48041
TLCD3A TLC domain containing 3A -3.42166
SORBS3 sorbin and SH3 domain containing 3 -3.31565
MELK maternal embryonic leucine zipper kinase -3.30799
GDF15 growth differentiation factor 15 -2.93693
KRT14 keratin 14, type I -2.75529
TLK2 tousled-like kinase 2 -2.52858
RXYLT1 ribitol xylosyltransferase 1 -2.46936
NGRN neugrin, neurite outgrowth associated -2.44156
ZNF646 zinc finger protein 646 -2.38074
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.19749
CD81 CD81 molecule -2.11857
ANKRD10 ankyrin repeat domain 10 -2.11665
PCCB propionyl CoA carboxylase, beta polypeptide -2.09404
CRYBG1 crystallin beta-gamma domain containing 1 -2.09359
TCF15 transcription factor 15 (basic helix-loop-helix) -2.07871
CCL22 chemokine (C-C motif) ligand 22 -2.0775
BBC3 BCL2 binding component 3 -2.06121
TRIP10 thyroid hormone receptor interactor 10 -2.00728
SETD1A SET domain containing 1A -2.00546