CRCGN016_MCF10A.WT.HP_24H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 33.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 5.72935
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.59486
NUP205 nucleoporin 205kDa 3.2044
OLFML2B olfactomedin-like 2B 2.79572
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.61014
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.31518
SCCPDH saccharopine dehydrogenase (putative) 2.29216
NCK1 NCK adaptor protein 1 2.17464
CHEK2 checkpoint kinase 2 2.169
TPX2 TPX2, microtubule-associated 2.1689
HBA1 hemoglobin, alpha 1 2.12414
ASDURF ASNSD1 upstream open reading frame 2.06769
TLCD3A TLC domain containing 3A 2.04528
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.04396
NUP93 nucleoporin 93kDa 2.01065

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -4.67149
BASP1 brain abundant, membrane attached signal protein 1 -4.59297
PMM2 phosphomannomutase 2 -4.56506
CHIC2 cysteine-rich hydrophobic domain 2 -4.36404
CAB39 calcium binding protein 39 -3.8489
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.68904
CANT1 calcium activated nucleotidase 1 -3.40288
TENT4A terminal nucleotidyltransferase 4A -3.28512
KIF20A kinesin family member 20A -3.20734
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -3.06737
MMP13 matrix metallopeptidase 13 -2.65283
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.62561
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.61436
PFN1 profilin 1 -2.61086
TEAD3 TEA domain family member 3 -2.3983
STXBP2 syntaxin binding protein 2 -2.3306
SBDS Shwachman-Bodian-Diamond syndrome -2.31193
EXT1 exostosin glycosyltransferase 1 -2.30403
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.2288
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.20132
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -2.19544
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -2.19321
ADGRF5 adhesion G protein-coupled receptor F5 -2.15638
HUNK hormonally up-regulated Neu-associated kinase -2.15596
ZNF548 zinc finger protein 548 -2.14851
MRPS10 mitochondrial ribosomal protein S10 -2.14219
ZNF787 zinc finger protein 787 -2.12336
XAB2 XPA binding protein 2 -2.12131
TTC23 tetratricopeptide repeat domain 23 -2.09218
NGF nerve growth factor (beta polypeptide) -2.06488
CLSTN3 calsyntenin 3 -2.05822
ACAN aggrecan -2.05541
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.04432
CMTR1 cap methyltransferase 1 -2.04009
SPIDR scaffolding protein involved in DNA repair -2.01573
LGI2 leucine-rich repeat LGI family, member 2 -2.01121
LAMA5 laminin, alpha 5 -2.00015