CRCGN016_MCF10A.WT.HP_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenyl-b-naphthylamine 100.46 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

124 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CRELD2 cysteine-rich with EGF-like domains 2 5.56835
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.80995
CNPY3 canopy FGF signaling regulator 3 4.7666
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.58795
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 3.0017
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.8497
TERF2IP telomeric repeat binding factor 2, interacting protein 2.6863
NCK2 NCK adaptor protein 2 2.61335
TMEM50B transmembrane protein 50B 2.5987
GET1 guided entry of tail-anchored proteins factor 1 2.4385
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.40715
ANKRD17 ankyrin repeat domain 17 2.3513
ECD ecdysoneless homolog (Drosophila) 2.35065
NUCB2 nucleobindin 2 2.3435
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.32993
GLRX glutaredoxin (thioltransferase) 2.31365
SDF2L1 stromal cell-derived factor 2-like 1 2.29255
TBPL1 TBP-like 1 2.27315
HMGA2 high mobility group AT-hook 2 2.25125
CDCA4 cell division cycle associated 4 2.2302
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.22495
STX1A syntaxin 1A (brain) 2.2131
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.2069
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.2047
CHD1 chromodomain helicase DNA binding protein 1 2.2009
TRIOBP TRIO and F-actin binding protein 2.1982
GPM6A glycoprotein M6A 2.17687
MACROH2A2 macroH2A.2 histone 2.17105
AXIN1 axin 1 2.1434
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.14165
WAPL WAPL cohesin release factor 2.11625
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.1025
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.09
ZBTB35 zinc finger and BTB domain containing 35 2.05888
CTPS1 CTP synthase 1 2.0565
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.05225
SAR1B secretion associated, Ras related GTPase 1B 2.0415
PPT2 palmitoyl-protein thioesterase 2 2.03405
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.02645
NCBP3 nuclear cap binding subunit 3 2.0257
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.02325
S100P S100 calcium binding protein P 2.0151
TRIM9 tripartite motif containing 9 2.00075

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -5.52818
NPDC1 neural proliferation, differentiation and control, 1 -5.5205
MSMO1 methylsterol monooxygenase 1 -5.30825
KDM3A lysine (K)-specific demethylase 3A -5.13115
CCNB1 cyclin B1 -4.39945
OXA1L oxidase (cytochrome c) assembly 1-like -4.2475
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.01065
HMG20B high mobility group 20B -4.00005
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.99793
SGK1 serum/glucocorticoid regulated kinase 1 -3.58525
TKT transketolase -3.35395
LPAR2 lysophosphatidic acid receptor 2 -3.12745
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) -3.02435
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.90165
ACAA1 acetyl-CoA acyltransferase 1 -2.78073
TENT4A terminal nucleotidyltransferase 4A -2.65815
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.62725
MTERF3 mitochondrial transcription termination factor 3 -2.62535
SST somatostatin -2.5247
SOAT2 sterol O-acyltransferase 2 -2.45687
CFAP45 cilia and flagella associated protein 45 -2.4424
CDK3 cyclin-dependent kinase 3 -2.4366
FGF4 fibroblast growth factor 4 -2.4331
GADD45B growth arrest and DNA-damage-inducible, beta -2.43003
TSPAN3 tetraspanin 3 -2.4098
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.4018
FOXJ1 forkhead box J1 -2.38
QARS1 glutaminyl-tRNA synthetase 1 -2.3673
NRIP1 nuclear receptor interacting protein 1 -2.36557
VSIG10 V-set and immunoglobulin domain containing 10 -2.3526
CCDC170 coiled-coil domain containing 170 -2.3518
NHERF4 NHERF family PDZ scaffold protein 4 -2.34365
RERGL RERG/RAS-like -2.32395
DNAI1 dynein, axonemal, intermediate chain 1 -2.2977
CLCNKB chloride channel, voltage-sensitive Kb -2.26925
IMMT inner membrane protein, mitochondrial -2.26205
MOB3B MOB kinase activator 3B -2.24815
STXBP2 syntaxin binding protein 2 -2.22715
TM4SF5 transmembrane 4 L six family member 5 -2.21565
GPR39 G protein-coupled receptor 39 -2.20485
CRLF2 cytokine receptor-like factor 2 -2.1948
MUC6 mucin 6, oligomeric mucus/gel-forming -2.19125
MRLN myoregulin -2.1802
TYRP1 tyrosinase-related protein 1 -2.17545
TOMM34 translocase of outer mitochondrial membrane 34 -2.1687
PRR15L proline rich 15-like -2.1644
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -2.15535
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.14925
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 -2.13625
TMEM184C transmembrane protein 184C -2.13605
DNAI4 dynein axonemal intermediate chain 4 -2.13265
PROM1 prominin 1 -2.13025
HLX H2.0-like homeobox -2.1277
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.11805
SPINK4 serine peptidase inhibitor, Kazal type 4 -2.11165
CCDC33 coiled-coil domain containing 33 -2.10625
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -2.10055
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.09615
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 -2.0858
EIF3G eukaryotic translation initiation factor 3, subunit G -2.08245
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.08245
BMP6 bone morphogenetic protein 6 -2.07315
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -2.06875
GREM2 gremlin 2, DAN family BMP antagonist -2.0679
JHY junctional cadherin complex regulator -2.06575
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.05805
KRT32 keratin 32, type I -2.0528
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -2.05273
CISH cytokine inducible SH2-containing protein -2.05095
NPR1 natriuretic peptide receptor 1 -2.04383
GPA33 glycoprotein A33 (transmembrane) -2.04095
DNAH6 dynein, axonemal, heavy chain 6 -2.03805
DNALI1 dynein, axonemal, light intermediate chain 1 -2.038
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.03645
JCAD junctional cadherin 5 associated -2.0253
SOX17 SRY (sex determining region Y)-box 17 -2.02125
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -2.0134
SSB Sjogren syndrome antigen B (autoantigen La) -2.0123
KATNIP katanin interacting protein -2.00815
PUS3 pseudouridylate synthase 3 -2.00575
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.0014