CRCGN016_MCF10A.WT.HP_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenyl-b-naphthylamine 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.18269
PPARG peroxisome proliferator-activated receptor gamma 3.88342
IDE insulin-degrading enzyme 3.86218
GPER1 G protein-coupled estrogen receptor 1 3.71343
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.65947
ACAA1 acetyl-CoA acyltransferase 1 3.49723
KCTD5 potassium channel tetramerization domain containing 5 3.42265
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.79159
ATP11B ATPase, class VI, type 11B 2.77144
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.7394
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.73065
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.60839
COX17 COX17 cytochrome c oxidase copper chaperone 2.39747
TMEM100 transmembrane protein 100 2.37039
NUCB2 nucleobindin 2 2.35894
SPAG4 sperm associated antigen 4 2.33863
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.29366
SPRY2 sprouty homolog 2 (Drosophila) 2.27479
IVL involucrin 2.2017
LARP7 La ribonucleoprotein domain family, member 7 2.19754
CENPE centromere protein E, 312kDa 2.18865
TM2D3 TM2 domain containing 3 2.15752
CCL20 chemokine (C-C motif) ligand 20 2.14252
PNRC2 proline-rich nuclear receptor coactivator 2 2.10685
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.09659
IL36G interleukin 36, gamma 2.05666
EXOC2 exocyst complex component 2 2.05081
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 2.04907
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.02549
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.0197
TLX1 T-cell leukemia homeobox 1 2.01589
LTN1 listerin E3 ubiquitin protein ligase 1 2.00185

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -7.43117
LAP3 leucine aminopeptidase 3 -6.24933
BASP1 brain abundant, membrane attached signal protein 1 -4.69862
SGK1 serum/glucocorticoid regulated kinase 1 -4.55431
SCYL3 SCY1-like 3 (S. cerevisiae) -4.47021
CCNB1 cyclin B1 -4.0935
GOLT1B golgi transport 1B -3.97576
MRPS2 mitochondrial ribosomal protein S2 -3.65099
PAEP progestagen-associated endometrial protein -3.33209
HEATR1 HEAT repeat containing 1 -3.30291
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.28742
CLDN5 claudin 5 -3.2108
TUBB6 tubulin, beta 6 class V -3.12426
CD44 CD44 molecule (Indian blood group) -3.11972
PRMT5 protein arginine methyltransferase 5 -3.08792
TCEA2 transcription elongation factor A (SII), 2 -3.08281
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.76357
ARID4B AT rich interactive domain 4B (RBP1-like) -2.76073
FBXO21 F-box protein 21 -2.68152
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.66259
RSAD2 radical S-adenosyl methionine domain containing 2 -2.62726
UBAC1 UBA domain containing 1 -2.59132
TKT transketolase -2.58076
CXCL12 chemokine (C-X-C motif) ligand 12 -2.57138
RGS2 regulator of G-protein signaling 2 -2.56973
THY1 Thy-1 cell surface antigen -2.55286
DAD1 defender against cell death 1 -2.51367
PIERCE1 piercer of microtubule wall 1 -2.49482
XPO7 exportin 7 -2.48924
GDF15 growth differentiation factor 15 -2.4658
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.45989
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.41258
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.39409
GADD45B growth arrest and DNA-damage-inducible, beta -2.39392
EIF3G eukaryotic translation initiation factor 3, subunit G -2.38928
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.37991
DNAI1 dynein, axonemal, intermediate chain 1 -2.36256
PDCD1LG2 programmed cell death 1 ligand 2 -2.3102
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.28562
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.27725
CD93 CD93 molecule -2.2693
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.26869
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.26156
PLAAT2 phospholipase A and acyltransferase 2 -2.25373
DRC3 dynein regulatory complex subunit 3 -2.24371
DHCR24 24-dehydrocholesterol reductase -2.23512
PNLIPRP2 pancreatic lipase-related protein 2 -2.21805
TENT2 terminal nucleotidyltransferase 2 -2.21248
ELOVL6 ELOVL fatty acid elongase 6 -2.20415
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.1947
PRDM12 PR domain containing 12 -2.18501
LMO2 LIM domain only 2 (rhombotin-like 1) -2.17515
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific -2.16431
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.14722
IFI44L interferon-induced protein 44-like -2.1472
STX5 syntaxin 5 -2.1449
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.12673
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.12092
MX1 MX dynamin-like GTPase 1 -2.11821
AVEN apoptosis, caspase activation inhibitor -2.11436
DSE dermatan sulfate epimerase -2.11424
FECH ferrochelatase -2.11284
WDR73 WD repeat domain 73 -2.11202
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.11032
TLR5 toll-like receptor 5 -2.10957
RNF11 ring finger protein 11 -2.10643
FRMD4A FERM domain containing 4A -2.10436
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.10425
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.10062
NUAK2 NUAK family, SNF1-like kinase, 2 -2.09543
TM9SF1 transmembrane 9 superfamily member 1 -2.08971
PEX11A peroxisomal biogenesis factor 11 alpha -2.08811
OLFM4 olfactomedin 4 -2.07968
RANBP17 RAN binding protein 17 -2.07611
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -2.07389
IRX4 iroquois homeobox 4 -2.06768
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.05665
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.0552
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.05342
LY6E lymphocyte antigen 6 complex, locus E -2.05328
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -2.03107
PDLIM4 PDZ and LIM domain 4 -2.02981
CYBRD1 cytochrome b reductase 1 -2.02913
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.02754
PNLIP pancreatic lipase -2.02134
PRR15L proline rich 15-like -2.01608
SOAT2 sterol O-acyltransferase 2 -2.01331