CRCGN016_MCF10A.WT.HP_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenyl-b-naphthylamine 11.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 4.84742
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.63864
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 4.62729
ABHD6 abhydrolase domain containing 6 4.62684
PEX11A peroxisomal biogenesis factor 11 alpha 4.32543
HBA1 hemoglobin, alpha 1 4.19204
SSBP2 single-stranded DNA binding protein 2 3.82628
AGR2 anterior gradient 2 3.77037
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.71266
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.5765
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.20927
TMEM186 transmembrane protein 186 2.75991
OLFM1 olfactomedin 1 2.51809
TRIP12 thyroid hormone receptor interactor 12 2.38185
CHL1 cell adhesion molecule L1-like 2.23728
LYSET lysosomal enzyme trafficking factor 2.19886
ARHGAP17 Rho GTPase activating protein 17 2.17375
CD99 CD99 molecule 2.09216
GSTZ1 glutathione S-transferase zeta 1 2.08529
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.06955
FHOD1 formin homology 2 domain containing 1 2.05639
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.0423

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.31211
CCDC86 coiled-coil domain containing 86 -4.64323
C2CD5 C2 calcium-dependent domain containing 5 -4.63472
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.54309
CDC25B cell division cycle 25B -3.86336
TRIB3 tribbles pseudokinase 3 -3.67818
BPHL biphenyl hydrolase-like (serine hydrolase) -2.87498
ANXA4 annexin A4 -2.67274
CA8 carbonic anhydrase VIII -2.65122
CNPY3-GNMT CNPY3-GNMT readthrough -2.57893
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.55624
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.51594
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.50896
MSMO1 methylsterol monooxygenase 1 -2.47179
ANXA2 annexin A2 -2.39572
HABP2 hyaluronan binding protein 2 -2.26437
LOC128125814 uncharacterized LOC128125814 -2.24244
BCAM basal cell adhesion molecule (Lutheran blood group) -2.14872
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.12898
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.11272
ELF4 E74-like factor 4 (ets domain transcription factor) -2.1046
ABT1 activator of basal transcription 1 -2.09098
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.00677
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -2.0009