CRCGN016_MCF10A.WT.HP_24H:E13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 98.95 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 7.22998
VAV3 vav 3 guanine nucleotide exchange factor 3.34672
ACAA1 acetyl-CoA acyltransferase 1 3.08844
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.92972
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.77947
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.7634
GASK1B golgi associated kinase 1B 2.65318
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.64501
GMIP GEM interacting protein 2.56266
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.53898
HIPK3 homeodomain interacting protein kinase 3 2.50629
NAP1L3 nucleosome assembly protein 1-like 3 2.48709
ZEB2 zinc finger E-box binding homeobox 2 2.4449
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.3857
PIPOX pipecolic acid oxidase 2.37587
KLHL9 kelch-like family member 9 2.27681
DAD1 defender against cell death 1 2.22971
PLSCR4 phospholipid scramblase 4 2.22833
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.18251
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.16721
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.15241
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.08624
ETNPPL ethanolamine-phosphate phospho-lyase 2.08326
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.06688
CLEC7A C-type lectin domain family 7, member A 2.04544
COX6C cytochrome c oxidase subunit VIc 2.04379
FOCAD focadhesin 2.02089
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.00097

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -4.97871
RPIA ribose 5-phosphate isomerase A -4.8232
PCNA proliferating cell nuclear antigen -4.61755
CAB39 calcium binding protein 39 -4.57569
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.38503
TENT4A terminal nucleotidyltransferase 4A -3.65597
PANK2 pantothenate kinase 2 -3.65277
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -3.29241
ZNF133 zinc finger protein 133 -3.20031
MMP9 matrix metallopeptidase 9 -2.98033
NSFL1C NSFL1 (p97) cofactor (p47) -2.91778
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.91092
H1-2 H1.2 linker histone, cluster member -2.67414
FKBP1C FK506 binding protein 1C -2.58623
KRT14 keratin 14, type I -2.57037
APMAP adipocyte plasma membrane associated protein -2.50738
DEFA4 defensin, alpha 4, corticostatin -2.48566
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.48139
PGLYRP1 peptidoglycan recognition protein 1 -2.46931
DNM1L dynamin 1-like -2.46054
NXT1 nuclear transport factor 2-like export factor 1 -2.44506
EMC10 ER membrane protein complex subunit 10 -2.40868
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.37843
GDF15 growth differentiation factor 15 -2.35547
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.34227
RRBP1 ribosome binding protein 1 -2.32111
TMEM230 transmembrane protein 230 -2.31902
MYOM1 myomesin 1 -2.31785
PCGF1 polycomb group ring finger 1 -2.3046
HBD hemoglobin, delta -2.29952
BEX4 brain expressed, X-linked 4 -2.28683
SPRY4 sprouty homolog 4 (Drosophila) -2.271
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.26424
NXPH3 neurexophilin 3 -2.25978
RBM38 RNA binding motif protein 38 -2.24636
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.23754
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.2354
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.22182
SNCB synuclein, beta -2.21969
AHSP alpha hemoglobin stabilizing protein -2.19984
UBOX5 U-box domain containing 5 -2.1913
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -2.19118
MED9 mediator complex subunit 9 -2.1882
RHCE Rh blood group, CcEe antigens -2.18372
GYPB glycophorin B (MNS blood group) -2.16399
MAVS mitochondrial antiviral signaling protein -2.15805
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.10959
MKKS McKusick-Kaufman syndrome -2.10839
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -2.09545
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.07404
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.06781
CD248 CD248 molecule, endosialin -2.06714
HSFX2 heat shock transcription factor family, X linked 2 -2.05881
OVGP1 oviductal glycoprotein 1, 120kDa -2.05323
TSPO2 translocator protein 2 -2.03423
MOSPD1 motile sperm domain containing 1 -2.02001
SCGB2A1 secretoglobin, family 2A, member 1 -2.01597