CRCGN016_MCF10A.WT.HP_24H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 32.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.6477
PEX11A peroxisomal biogenesis factor 11 alpha 3.88673
SNAP25 synaptosomal-associated protein, 25kDa 3.68787
SPAG4 sperm associated antigen 4 3.63483
CCP110 centriolar coiled coil protein 110kDa 3.39321
KDM5A lysine (K)-specific demethylase 5A 3.20216
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.66855
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.5821
ELOVL2 ELOVL fatty acid elongase 2 2.55025
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.23139
SYT1 synaptotagmin I 2.10028
ARID4A AT rich interactive domain 4A (RBP1-like) 2.07778
MYRIP myosin VIIA and Rab interacting protein 2.01103
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 2.00578
IARS1 isoleucyl-tRNA synthetase 1 2.00196

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -3.68358
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.60755
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.22364
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.98331
ANXA2 annexin A2 -2.90562
RPA3 replication protein A3, 14kDa -2.53938
RBM34 RNA binding motif protein 34 -2.42462
FASTKD5 FAST kinase domains 5 -2.41092
NANOS2 nanos homolog 2 (Drosophila) -2.3749
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.28007
KRT14 keratin 14, type I -2.13423
BASP1 brain abundant, membrane attached signal protein 1 -2.11754
DIO3 deiodinase, iodothyronine, type III -2.08858
CCNB2 cyclin B2 -2.03314
MRPL30 mitochondrial ribosomal protein L30 -2.01033