CRCGN016_MCF10A.WT.HP_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 10.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.94335
CXCL2 chemokine (C-X-C motif) ligand 2 4.61797
SOX2 SRY (sex determining region Y)-box 2 3.48805
SESN1 sestrin 1 3.35752
CCL2 chemokine (C-C motif) ligand 2 3.21434
AGR2 anterior gradient 2 2.65978
FBXL12 F-box and leucine-rich repeat protein 12 2.65296
GET1 guided entry of tail-anchored proteins factor 1 2.64519
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.29413
BTK Bruton agammaglobulinemia tyrosine kinase 2.28083
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.25409
CXCL3 chemokine (C-X-C motif) ligand 3 2.11092
CCNF cyclin F 2.0672
NCAPG2 non-SMC condensin II complex, subunit G2 2.05412
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.02391

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.88271
BAG3 BCL2-associated athanogene 3 -5.11377
DERA deoxyribose-phosphate aldolase (putative) -4.51212
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.08903
TRAPPC3 trafficking protein particle complex 3 -3.83267
TUBB6 tubulin, beta 6 class V -3.62531
OXA1L oxidase (cytochrome c) assembly 1-like -3.16248
TIMP1 TIMP metallopeptidase inhibitor 1 -2.86055
MRPS15 mitochondrial ribosomal protein S15 -2.65823
TM9SF3 transmembrane 9 superfamily member 3 -2.59247
CSK c-src tyrosine kinase -2.53895
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.53418
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.35283
MDFI MyoD family inhibitor -2.15104
ZMYM6 zinc finger, MYM-type 6 -2.10889
ACAA1 acetyl-CoA acyltransferase 1 -2.108