CRCGN016_MCF10A.WT.HP_24H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl acetate 34.67 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.95015
SNAP25 synaptosomal-associated protein, 25kDa 4.68665
C2CD2 C2 calcium-dependent domain containing 2 4.5176
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.85149
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.94767
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.80927
OLFM1 olfactomedin 1 2.60016
ACE2 angiotensin I converting enzyme 2 2.57461
NEFM neurofilament, medium polypeptide 2.52127
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.47084
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.42906
FGFR4 fibroblast growth factor receptor 4 2.42498
RSF1 remodeling and spacing factor 1 2.41706
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.41559
KCTD14 potassium channel tetramerization domain containing 14 2.3968
RBBP7 retinoblastoma binding protein 7 2.36925
NELL1 NEL-like 1 (chicken) 2.32099
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.28887
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.28486
SCG3 secretogranin III 2.28155
STMN2 stathmin 2 2.27331
UVRAG UV radiation resistance associated 2.26695
CALML4 calmodulin-like 4 2.26615
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.26391
MYO1A myosin IA 2.25794
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.21875
WDR4 WD repeat domain 4 2.21096
VIL1 villin 1 2.20995
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.20097
CAPN5 calpain 5 2.20015
DOK4 docking protein 4 2.19947
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.18291
CLCN5 chloride channel, voltage-sensitive 5 2.15518
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.15274
SESN1 sestrin 1 2.15175
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.14289
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.11653
LGI1 leucine-rich, glioma inactivated 1 2.11653
SYN1 synapsin I 2.10811
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.10436
SSUH2 ssu-2 homolog (C. elegans) 2.08536
NYNRIN NYN domain and retroviral integrase containing 2.06335
CHGB chromogranin B 2.05081
NEFL neurofilament, light polypeptide 2.0235
BEX2 brain expressed X-linked 2 2.01502
AAMDC adipogenesis associated, Mth938 domain containing 2.01258

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -5.36167
MSMO1 methylsterol monooxygenase 1 -5.15293
HMG20B high mobility group 20B -4.50078
KRT14 keratin 14, type I -3.44813
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.05877
NT5DC2 5'-nucleotidase domain containing 2 -2.7721
PFN1 profilin 1 -2.75686
ARID4B AT rich interactive domain 4B (RBP1-like) -2.58676
REEP5 receptor accessory protein 5 -2.58
ACAA1 acetyl-CoA acyltransferase 1 -2.37515
CD9 CD9 molecule -2.32731
ZFHX4 zinc finger homeobox 4 -2.27387
DUSP4 dual specificity phosphatase 4 -2.22223
KLHL2 kelch-like family member 2 -2.09901
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.07613
GDF15 growth differentiation factor 15 -2.0099