CRCGN016_MCF10A.WT.HP_24H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 101.85 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

151 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IDE insulin-degrading enzyme 5.1015
MAMLD1 mastermind-like domain containing 1 4.9371
CADM1 cell adhesion molecule 1 4.82695
KCTD5 potassium channel tetramerization domain containing 5 4.3011
PRKX protein kinase, X-linked 3.8927
IGHMBP2 immunoglobulin mu binding protein 2 3.41725
TBPL1 TBP-like 1 3.21435
LCE2B late cornified envelope 2B 3.19185
KDM5A lysine (K)-specific demethylase 5A 3.16213
FZD7 frizzled class receptor 7 2.78057
KRT6B keratin 6B, type II 2.76715
GLRX glutaredoxin (thioltransferase) 2.71872
HMGA2 high mobility group AT-hook 2 2.6967
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.69115
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.6775
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.6305
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.5968
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 2.56815
MSRA methionine sulfoxide reductase A 2.56305
CTNNBIP1 catenin, beta interacting protein 1 2.5574
KRT2 keratin 2, type II 2.5572
NT5DC3 5'-nucleotidase domain containing 3 2.5479
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.5477
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.51975
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.51875
MED8 mediator complex subunit 8 2.51402
CA6 carbonic anhydrase VI 2.4985
MTM1 myotubularin 1 2.47158
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.43555
BCCIP BRCA2 and CDKN1A interacting protein 2.41515
LORICRIN loricrin cornified envelope precursor protein 2.3725
CD33 CD33 molecule 2.32985
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.3255
MORC4 MORC family CW-type zinc finger 4 2.3099
NUP155 nucleoporin 155kDa 2.30945
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.29355
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.27365
H2AZ2 H2A.Z variant histone 2 2.26355
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.25515
ZIM2 zinc finger, imprinted 2 2.25475
CHUK conserved helix-loop-helix ubiquitous kinase 2.2537
OR51E2 olfactory receptor, family 51, subfamily E, member 2 2.24505
RGS2 regulator of G-protein signaling 2 2.2326
ELF5 E74-like factor 5 (ets domain transcription factor) 2.22645
HAL histidine ammonia-lyase 2.22283
EGR1 early growth response 1 2.21578
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.21415
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.2132
BACE2 beta-site APP-cleaving enzyme 2 2.1921
NECAB2 N-terminal EF-hand calcium binding protein 2 2.18065
CREB3L2 cAMP responsive element binding protein 3-like 2 2.1796
FGF16 fibroblast growth factor 16 2.17155
DGKI diacylglycerol kinase, iota 2.16515
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.16195
LHX2 LIM homeobox 2 2.15053
CARD9 caspase recruitment domain family, member 9 2.1415
MTMR12 myotubularin related protein 12 2.1409
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.14045
CALR calreticulin 2.13423
BMAL2 basic helix-loop-helix ARNT like 2 2.1307
LIM2 lens intrinsic membrane protein 2, 19kDa 2.12195
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 2.1156
TG thyroglobulin 2.1122
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.10845
C4BPB complement component 4 binding protein, beta 2.10595
WAPL WAPL cohesin release factor 2.10063
TLR6 toll-like receptor 6 2.0993
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.09845
AURKC aurora kinase C 2.09495
KCTD14 potassium channel tetramerization domain containing 14 2.0885
KPLCE KPRP N-terminal and LCE C-terminal like protein 2.0885
CDSN corneodesmosin 2.08502
SPX spexin hormone 2.0818
GRIK3 glutamate receptor, ionotropic, kainate 3 2.08
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.07505
DSG1 desmoglein 1 2.074
PRSS53 protease, serine, 53 2.0619
FJX1 four jointed box 1 (Drosophila) 2.05565
KDM5C lysine (K)-specific demethylase 5C 2.05475
ANKH ANKH inorganic pyrophosphate transport regulator 2.05375
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 2.0523
ARHGAP22 Rho GTPase activating protein 22 2.05225
GOLGA3 golgin A3 2.04635
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2.03985
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.03795
CCKAR cholecystokinin A receptor 2.035
COQ8A coenzyme Q8A 2.0334
EPHB1 EPH receptor B1 2.03325
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.0269
ERCC2 excision repair cross-complementation group 2 2.0267
CYREN cell cycle regulator of NHEJ 2.02055
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.0177
GPR12 G protein-coupled receptor 12 2.01125
EMX1 empty spiracles homeobox 1 2.0108
MARCHF5 membrane associated ring-CH-type finger 5 2.00765
MAOB monoamine oxidase B 2.0068
VAX2 ventral anterior homeobox 2 2.00065
ANGPTL3 angiopoietin-like 3 2.00055
SLC12A8 solute carrier family 12, member 8 2.0005

decreased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 -6.2883
BAG3 BCL2-associated athanogene 3 -5.21285
MSMO1 methylsterol monooxygenase 1 -5.1588
MPC2 mitochondrial pyruvate carrier 2 -5.0531
CD81 CD81 molecule -5.0189
ARID4B AT rich interactive domain 4B (RBP1-like) -4.61205
BASP1 brain abundant, membrane attached signal protein 1 -4.5835
FASTKD5 FAST kinase domains 5 -4.57205
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.51835
ALDOC aldolase C, fructose-bisphosphate -4.26665
EIF5 eukaryotic translation initiation factor 5 -4.19738
JMJD6 jumonji domain containing 6 -4.02487
ZNF394 zinc finger protein 394 -3.05495
TCEA2 transcription elongation factor A (SII), 2 -3.0448
ANKRD10 ankyrin repeat domain 10 -2.90295
REEP5 receptor accessory protein 5 -2.83077
RBM7 RNA binding motif protein 7 -2.82775
PRR15L proline rich 15-like -2.8259
PRKCD protein kinase C, delta -2.79055
MYLIP myosin regulatory light chain interacting protein -2.6787
STMN1 stathmin 1 -2.6388
RNF11 ring finger protein 11 -2.5142
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.40887
ATP13A2 ATPase type 13A2 -2.3856
SMAD7 SMAD family member 7 -2.3695
MRPS7 mitochondrial ribosomal protein S7 -2.35275
CH25H cholesterol 25-hydroxylase -2.27535
SLC35A5 solute carrier family 35, member A5 -2.2637
MVP major vault protein -2.26115
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.24043
TMEM47 transmembrane protein 47 -2.2233
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.19618
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.1811
ING1 inhibitor of growth family, member 1 -2.16928
RLF rearranged L-myc fusion -2.16085
RNF139 ring finger protein 139 -2.15105
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.13405
CTSZ cathepsin Z -2.1301
KLF10 Kruppel-like factor 10 -2.12545
TIMELESS timeless circadian clock -2.1237
COA3 cytochrome c oxidase assembly factor 3 -2.1235
RPS5 ribosomal protein S5 -2.07635
MED17 mediator complex subunit 17 -2.0744
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.06225
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.05005
TMEM14A transmembrane protein 14A -2.0499
DDIT4 DNA-damage-inducible transcript 4 -2.0468
AGPS alkylglycerone phosphate synthase -2.03595
CCNE1 cyclin E1 -2.02965
PNRC2 proline-rich nuclear receptor coactivator 2 -2.01055
NCAPD2 non-SMC condensin I complex, subunit D2 -2.00895
MSL2 male-specific lethal 2 homolog (Drosophila) -2.0066