CRCGN016_MCF10A.WT.HP_24H:E24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 11.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:E24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MCOLN1 mucolipin 1 4.53994
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.83288
LGMN legumain 3.31178
MELK maternal embryonic leucine zipper kinase 2.93638
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.8695
TIAM1 T-cell lymphoma invasion and metastasis 1 2.75277
CEPT1 choline/ethanolamine phosphotransferase 1 2.57165
COMP cartilage oligomeric matrix protein 2.5597
NUTF2 nuclear transport factor 2 2.38694
MSRA methionine sulfoxide reductase A 2.36887
PNPLA6 patatin-like phospholipase domain containing 6 2.34188
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.33883
DENND2D DENN/MADD domain containing 2D 2.2435
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 2.21778
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.12531
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.07438
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.06606
MTA2 metastasis associated 1 family, member 2 2.04057

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.41051
HMG20B high mobility group 20B -5.00333
BASP1 brain abundant, membrane attached signal protein 1 -4.58315
HOXA5 homeobox A5 -4.40429
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.15487
S100A8 S100 calcium binding protein A8 -3.8091
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.58526
TLK2 tousled-like kinase 2 -3.18405
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.05465
ACAA1 acetyl-CoA acyltransferase 1 -2.74183
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.64123
ARID4B AT rich interactive domain 4B (RBP1-like) -2.52751
CANT1 calcium activated nucleotidase 1 -2.44354
KDM3A lysine (K)-specific demethylase 3A -2.38056
ALDOC aldolase C, fructose-bisphosphate -2.36446
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.26682
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.23588
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 -2.22313
GPATCH1 G patch domain containing 1 -2.18979
FAAP24 FA core complex associated protein 24 -2.14612
TBCB tubulin folding cofactor B -2.1377
NRIP1 nuclear receptor interacting protein 1 -2.13638
TALDO1 transaldolase 1 -2.09833
APMAP adipocyte plasma membrane associated protein -2.06407
FAM169A family with sequence similarity 169, member A -2.04998
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.01581
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.00882
TIMP1 TIMP metallopeptidase inhibitor 1 -2.00015